Circulating insulin-like growth factor system adaptations in hibernating brown bears indicate increased tissue IGF availability

Autor: Anne Mette Frøbert, Malene Brohus, Tinna S. Roesen, Jonas Kindberg, Ole Fröbert, Cheryl A. Conover, Michael T. Overgaard

Publikováno v: Frøbert, A M, Brohus, M, Roesen, T S, Kindberg, J, Fröbert, O, Conover, C A & Overgaard, M T 2022, ' Circulating insulin-like growth factor system adaptations in hibernating brown bears indicate increased tissue IGF availability ', American Journal of Physiology-Endocrinology and Metabolism, vol. 323, no. 3, pp. E307-E318 . https://doi.org/10.1152/ajpendo.00429.2021
Frøbert, A M, Brohus, M, Roesen, T S, Kindberg, J, Fröbert, O, Conover, C A & Overgaard, M T 2022, ' Circulating insulin-like growth factor system adaptations in hibernating brown bears indicate increased tissue IGF availability ', American Journal of Physiology: Endocrinology and Metabolism, vol. 323, no. 3, pp. E307-E318 . https://doi.org/10.1152/ajpendo.00429.2021

Brown bears conserve muscle and bone mass during 6 mo of inactive hibernation. The molecular mechanisms underlying hibernation physiology may have translational relevance for human therapeutics. We hypothesize that protective mechanisms involve incre

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