Výsledky vyhledávání - "Insulin receptor complex"

Akademický článek

Association and Phosphorylation-Dependent Dissociation of Proteins in the Insulin Receptor Complex

Autor: Zhang, Wengang, Johnson, Jeffrey D., Rutter, William J.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 1993 Dec 01. 90(23), 11317-11321.

Externí odkaz: https://www.jstor.org/stable/2363700

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Akademický článek

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Dephosphorylation of clustered phosphoserine residues in human Grb14 by protein phosphatase 1 and its effect on insulin receptor complex formation

Autor: Keisuke Yoshida, Junichi Taira, Misaki Takemoto, Hiroshi Sakamoto, Kousuke Hanada

Publikováno v: Journal of Peptide Science. 25

The physical interaction of the human growth factor receptor-bound protein 14 (hGrb14) and the insulin receptor (IR) represses insulin signaling. With respect to the recruiting mechanism of hGrb14 to IR respond to insulin stimulus, our previous repor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa4de48016ac718885d6abb31f6d63a5
https://doi.org/10.1002/psc.3207

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Role of surface-exposed charged basic amino acids (Lys, Arg) and guanidination in insulin on the interaction and stability of insulin–insulin receptor complex

Autor: Umah Rani Kuppusamy, Pak Kheong Tan, Vannajan Sanghiran Lee, Sri Devi Sukumaran, Bavani Arumugam

Publikováno v: Computational Biology and Chemistry. 92:107501

Naturally occurring proteins are emerging as novel therapeutics in the protein-based biopharmaceutical industry for the treatment of diabetes and obesity. However, proteins are not suitable for oral delivery due to short half-life, reduced physical a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d298bd336d518b15465a47f758f7c31
https://doi.org/10.1016/j.compbiolchem.2021.107501

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Akademický článek

Quaternary Structure of the Insulin-Insulin Receptor Complex.

Autor: Luo, Robert Z.-T., Beniac, Daniel R., Fernandes, Allan, Yip, Cecil C., Ottensmeyer, F.P.

Publikováno v: Science. 8/13/1999, Vol. 285 Issue 5430, p1077-1080. 4p. 14 Color Photographs, 3 Black and White Photographs, 1 Diagram, 1 Graph.

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Insulin/receptor binding: the last piece of the puzzle? What recent progress on the structure of the insulin/receptor complex tells us (or not) about negative cooperativity and activation

Autor: Pierre De Meyts

Publikováno v: BioEssays : news and reviews in molecular, cellular and developmental biology. 37(4)

Progress in solving the structure of insulin bound to its receptor has been slow and stepwise, but a milestone has now been reached with a refined structure of a complex of insulin with a “microreceptor” that contains the primary binding site. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23575563387ec48408e36d3bb1ceedd1
https://pubmed.ncbi.nlm.nih.gov/25630923

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A Ser for Cys Mutation in the Extracellular Portion of Insulin Receptor β-Subunit Impairs the Insulin-Insulin Receptor Complex Internalization in CHO Cells

Autor: Davide Maggi, Gabriella Andraghetti, Renzo Cordera

Publikováno v: Biochemical and Biophysical Research Communications. 210:931-937

We investigated the effects of a ser for cys 860 mutation, located in the extracellular portion of insulin receptor beta subunit, on several receptor functions. CHO cells, stably transfected with the mutated cDNA, were used for this study. In the pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::999b447a0e2109eb80de17695c613a59
https://doi.org/10.1006/bbrc.1995.1746

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