Zobrazeno 1 - 10
of 2 420
pro vyhledávání: '"Insulin oscillation"'
Autor:
Shiuhwei Chen, ZhiJiang Huang, Harrison Kidd, Min Kim, Eul Hyun Suh, Shangkui Xie, Ebrahim H. Ghazvini Zadeh, Yan Xu, A. Dean Sherry, Philipp E. Scherer, Wen-hong Li
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Appropriate insulin secretion is essential for maintaining euglycemia, and impairment or loss of insulin release represents a causal event leading to diabetes. There have been extensive efforts of studying insulin secretion and its regulation using a
Externí odkaz:
https://doaj.org/article/3cc8fee9653e4262885de5dece07ea1e
Autor:
Nilam, Saloni Rathee
Publikováno v:
Journal of Applied Nonlinear Dynamics. 8:493-507
In the present paper, we extend our attempt of modeling the closed loop control of glucose concentration level by considering three time delays for the proper functioning of artificial pancreas. Several time delays exist in the glucose - insulin reg
Autor:
I. Johanna Stamper, Xujing Wang
Publikováno v:
Journal of Theoretical Biology. 475:1-24
The integrated multiscale mathematical model we present in this paper is built on two of our previous ones: a model of electrical oscillation in β-cells connected to neighboring cells within a three-dimensional (3D) network, and a model of glucose-i
Autor:
Piotr Fichna, Marta Fichna
Publikováno v:
Endokrynologia Polska. 68:568-573
Glucocorticoids (GCs) play a pivotal role in carbohydrate metabolism. They counteract insulin by decreasing peripheral glucose uptake and stimulating hepatic gluconeogenesis, although they are best known for inducing insulin resistance (IR). Moreover
Publikováno v:
Biochemical and Biophysical Research Communications. 493:409-415
Diabetes mellitus affects ion channel physiology. We have previously reported that acute application of insulin suppresses the KCNQ1/KCNE1 currents that play an important role in terminating ventricular action potential. In this study, we investigate
Autor:
Sukanta Jash, Garrett Heinrich, Christopher C. Marino, Simona S. Ghanem, Hilda E. Ghadieh, Cara Gatto-Weis, Kevin Y. Lee, Julie C. Hanna, Harrison T. Muturi, Sonia M. Najjar, Vishwajeet Puri, Saja S. Khuder, Lucia Russo
Publikováno v:
Hepatology Communications
Exenatide, a glucagon‐like peptide‐1 receptor agonist, induces insulin secretion. Its role in insulin clearance has not been adequately examined. Carcinoembryonic antigen‐related cell adhesion molecule 1 (CEACAM1) promotes hepatic insulin clear
Autor:
Franz M. Matschinsky, Pan Chen, Nicolai M. Doliba, Chengyang Liu, Ali Naji, Qin Liu, Changhong Li
Publikováno v:
Molecular Metabolism, Vol 6, Iss 10, Pp 1240-1253 (2017)
Molecular Metabolism
Molecular Metabolism
Objectives Chronic hyperlipidemia and hyperglycemia are characteristic features of type 2 diabetes (T2DM) that are thought to cause or contribute to β-cell dysfunction by “glucolipotoxicity.” Previously we have shown that acute treatment of panc
Autor:
Nina Wronkowitz, In Young Choi, Ira Indrakusuma, Jürgen Eckel, Park Sung Hee, Daniela Dietze-Schroeder, Se Chang Kwon, Sven W. Görgens, Thorsten Hartmann, Yeonjoo Kang, Young-Mi Lee, Marcus Hompesch
Publikováno v:
Diabetes, Obesity and Metabolism. 19:1722-1731
Aims Developing a safe, while more convenient long-acting basal insulin for diabetic patients is still an unmet medical need. Thus, we conducted a comprehensive pre-clinical study of the novel ultra-long acting insulin analogue LAPSInsulin115. Method
Publikováno v:
Diabetes. 66:2400-2406
Insulin clamp studies have shown that the suppressive actions of insulin on endogenous glucose production (EGP) are markedly more sensitive than for stimulating glucose disposal (Rd). However, clamp conditions do not adequately mimic postprandial phy
Autor:
Jean-Claude Henquin, Myriam Nenquin
Publikováno v:
Journal of Diabetes Investigation
Journal of Diabetes Investigation, Vol. xx, no.xx, p. xx (2017)
Journal of Diabetes Investigation, Vol. xx, no.xx, p. xx (2017)
Human β‐cells are functionally mature by the age of 1 year. The timeline and mechanisms of this maturation are unknown owing to the exceptional availability of testable tissue. Here, we report the first in vitro study of insulin secretion by islet