Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Insulin granule"'
Autor:
Alexia Carré, Roberto Mallone
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Autoimmune type 1 diabetes (T1D) results from the intricate crosstalk of various immune cell types. CD8+ T cells dominate the pro-inflammatory milieu of islet infiltration (insulitis), and are considered as key effectors of beta-cell destruction, thr
Externí odkaz:
https://doaj.org/article/db64dc0fe4124a0ab2bf16679883f0a7
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Autor:
Gaelle R. Carrat, Elizabeth Haythorne, Alejandra Tomas, Leena Haataja, Andreas Müller, Peter Arvan, Alexandra Piunti, Kaiying Cheng, Mutian Huang, Timothy J. Pullen, Eleni Georgiadou, Theodoros Stylianides, Nur Shabrina Amirruddin, Victoria Salem, Walter Distaso, Andrew Cakebread, Kate J. Heesom, Philip A. Lewis, David J. Hodson, Linford J. Briant, Annie C.H. Fung, Richard B. Sessions, Fabien Alpy, Alice P.S. Kong, Peter I. Benke, Federico Torta, Adrian Kee Keong Teo, Isabelle Leclerc, Michele Solimena, Dale B. Wigley, Guy A. Rutter
Publikováno v:
Molecular Metabolism, Vol 40, Iss , Pp 101015- (2020)
Objective: Risk alleles for type 2 diabetes at the STARD10 locus are associated with lowered STARD10 expression in the β-cell, impaired glucose-induced insulin secretion, and decreased circulating proinsulin:insulin ratios. Although likely to serve
Externí odkaz:
https://doaj.org/article/075506f07a044c31be2e44b42ccc2527
Publikováno v:
Biomolecules, Vol 12, Iss 2, p 335 (2022)
Pancreatic islet β-cells exhibit tremendous plasticity for secretory adaptations that coordinate insulin production and release with nutritional demands. This essential feature of the β-cell can allow for compensatory changes that increase secretor
Externí odkaz:
https://doaj.org/article/a80f3bcbd8324d9cadb0474fb8129f28
Akademický článek
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Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12820, p 12820 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
β-cells convert glucose (input) resulting in the controlled release of insulin (output), which in turn has the role to maintain glucose homeostasis. β-cell function is regulated by a complex interplay between the metabolic processing of the input,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fe9c36e2c46711848ac3a072890f387
https://www.mdpi.com/1422-0067/22/23/12820
https://www.mdpi.com/1422-0067/22/23/12820
Autor:
Theodoros Stylianides, Fabien Alpy, Peter I. Benke, Alexandra Piunti, Victoria Salem, Michele Solimena, Alejandra Tomas, David J. Hodson, Andrew Cakebread, Andreas Müller, Kate J. Heesom, Nur Shabrina Amirruddin, Federico Torta, Isabelle Leclerc, Leena Haataja, Peter Arvan, Timothy J. Pullen, Annie C. H. Fung, Linford J.B. Briant, Kaiying Cheng, Gaelle Carrat, Alice P.S. Kong, Dale B. Wigley, Philip A. Lewis, Richard B. Sessions, Elizabeth Haythorne, Mutian Huang, Adrian Kee Keong Teo, Guy A. Rutter, Eleni Georgiadou, Walter Distaso
Publikováno v:
Molecular Metabolism
Molecular metabolism
Molecular metabolism, Elsevier, 2020, 40, pp.101015. ⟨10.1016/j.molmet.2020.101015⟩
bioRxiv
Molecular metabolism, 2020, 40, pp.101015. ⟨10.1016/j.molmet.2020.101015⟩
Molecular Metabolism, Vol 40, Iss, Pp 101015-(2020)
Carrat, G, Haythorne, E, Tomas, A, Haataja, L, Muller, A, Arvan, P, Piunti, A, Cheng, K, Huang, M, Pullen, T J, Georgiadou, E, Stylianides, T, Amirruddin, N S, Salem, V, Distaso, W, Cakebread, A, Heesom, K J, Lewis, P A, Hodson, D J, Briant, L J B, Fung, A, Sessions, R B, Alpy, F, Kong, A, Benke, P, Torta, F, Keong Teo, A K, Leclerc, I, Solimena, M, Wigley, DB & Rutter, G A 2020, ' The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis ', Molecular metabolism, vol. 40, 101015 . https://doi.org/10.1016/j.molmet.2020.101015
Molecular metabolism
Molecular metabolism, Elsevier, 2020, 40, pp.101015. ⟨10.1016/j.molmet.2020.101015⟩
bioRxiv
Molecular metabolism, 2020, 40, pp.101015. ⟨10.1016/j.molmet.2020.101015⟩
Molecular Metabolism, Vol 40, Iss, Pp 101015-(2020)
Carrat, G, Haythorne, E, Tomas, A, Haataja, L, Muller, A, Arvan, P, Piunti, A, Cheng, K, Huang, M, Pullen, T J, Georgiadou, E, Stylianides, T, Amirruddin, N S, Salem, V, Distaso, W, Cakebread, A, Heesom, K J, Lewis, P A, Hodson, D J, Briant, L J B, Fung, A, Sessions, R B, Alpy, F, Kong, A, Benke, P, Torta, F, Keong Teo, A K, Leclerc, I, Solimena, M, Wigley, DB & Rutter, G A 2020, ' The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis ', Molecular metabolism, vol. 40, 101015 . https://doi.org/10.1016/j.molmet.2020.101015
Objective Risk alleles for type 2 diabetes at the STARD10 locus are associated with lowered STARD10 expression in the β-cell, impaired glucose-induced insulin secretion, and decreased circulating proinsulin:insulin ratios. Although likely to serve a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ee31ae299bb38311feeaf4ba6eff987
http://hdl.handle.net/10044/1/80098
http://hdl.handle.net/10044/1/80098
Autor:
Decio L. Eizirik, Laura Nigi, Shalinee Dhayal, Francesco Dotta, Pia Leete, Guido Sebastiani, Varpu Marjomäki, Noel G. Morgan, Sarah J. Richardson, Mark Russell, Eseoghene Ifie
Publikováno v:
Diabetologia
Diabetologia, 61 (11
Diabetologia, 61 (11
Aims/hypothesis: The Coxsackie and adenovirus receptor (CAR) is a transmembrane cell-adhesion protein that serves as an entry receptor for enteroviruses and may be essential for their ability to infect cells. Since enteroviral infection of beta cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::901cfd8509638098421663dad5a21d94
http://europepmc.org/articles/PMC6182664
http://europepmc.org/articles/PMC6182664
Akademický článek
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