Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Insulin Secreting Cell"'
Autor:
DAddio, Francesca, Maestroni, Anna, Assi, Emma, Ben Nasr, Moufida, Amabile, Giovanni, Usuelli, Vera, Loretelli, Cristian, Bertuzzi, Federico, Antonioli, Barbara, Cardarelli, Francesco, El Essawy, Basset, Solini, Anna, Gerling, Ivan C., Bianchi, Cristina, Becchi, Gabriella, Mazzucchelli, Serena, Corradi, Domenico, Fadini, Gian Paolo, Foschi, Diego, Markmann, James F., Orsi, Emanuela, Skrha, Jan, Camboni, Maria Gabriella, Abdi, Reza, Shapiro, A. M. James, Folli, Franco, Ludvigsson, Johnny, Del Prato, Stefano, Zuccotti, Gianvincenzo, Fiorina, Paolo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
In this new study the Authors demonstrated that the IGFBP3/TMEM219 pathway is a physiological regulator of pancreatic beta cell homeostasis and it is dysregulated in diabetes. IGFBP3/TMEM219 targeting may therefore serve as a therapeutic option in di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::16a1637726e38a17c6ee19d54febc12a
https://doaj.org/article/691fd79ad7294c7890d97254a673270c
https://doaj.org/article/691fd79ad7294c7890d97254a673270c
Publikováno v:
BMC Endocrine Disorders, Vol 21, Iss 1, Pp 1-7 (2021)
BMC Endocrine Disorders
BMC Endocrine Disorders
Background Maturity Onset Diabetes of the Young (MODY) is a monogenic, autosomal, dominant disease that results in beta-cells dysfunction with consequent hyperglycaemia. It represents a rare form of diabetes (1–2% of all the cases). Sulphonylureas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44a97607cd8f8251ca5feeff122dc14f
https://doaj.org/article/9ca1f2b9ff104e78bd85d95e82552723
https://doaj.org/article/9ca1f2b9ff104e78bd85d95e82552723
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12820, p 12820 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
β-cells convert glucose (input) resulting in the controlled release of insulin (output), which in turn has the role to maintain glucose homeostasis. β-cell function is regulated by a complex interplay between the metabolic processing of the input,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fe9c36e2c46711848ac3a072890f387
https://www.mdpi.com/1422-0067/22/23/12820
https://www.mdpi.com/1422-0067/22/23/12820
Akademický článek
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Autor:
Bechara Mfarrej, Nicola Gagliani, Manuela Battaglia, Georgia Fousteri, Cristina Morsiani, Tatiana Jofra
Publikováno v:
Clin Exp Immunol
Summary T regulatory type 1 (Tr1) cells are a class of regulatory T cells (Tregs) participating in peripheral tolerance, hence the rationale behind their testing in clinical trials in different disease settings. One of their applications is tolerance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d869b79de5d2b3b1409187a8bb2f5a9
https://europepmc.org/articles/PMC7366746/
https://europepmc.org/articles/PMC7366746/
Publikováno v:
Medical Hypotheses
The CoV-19 infection appears to be unusual among patients with type 1 Diabetes Mellitus, although they are considered a fragile population. We think that this in part due to the peculiar immune condition that leads to the destruction of the Beta cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4161340180550be5f5aebea52192fc54
https://pubmed.ncbi.nlm.nih.gov/32416410
https://pubmed.ncbi.nlm.nih.gov/32416410
Autor:
Rita Nano, Riccardo C. Bonadonna, Lorenzo Piemonti, Raffaella Melzi, Alessia Mercalli, Gianpaolo Balzano, Marina Scavini
Publikováno v:
Cell Transplantation, Vol 25 (2016)
Islet volume and endocrine pancreas architecture (islet size distribution) may be independent determinants of β-cell function. Furthermore, the accuracy of homeostatic model assessment (HOMA) indexes in predicting β-cell mass has never been assesse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc0351e1b4fb154cc1aaf308be4da505
https://doi.org/10.3727/096368915x688498
https://doi.org/10.3727/096368915x688498
Publikováno v:
Acta Diabetologica
In patients with type 1 diabetes (T1D), pancreatic β cells are destroyed by a selective autoimmune attack and their replacement with functional insulin-producing cells is the only possible cure for this disease. The field of islet transplantation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03202436040aa8f93421588efcf4dd6b
https://doi.org/10.1007/s00592-016-0847-z
https://doi.org/10.1007/s00592-016-0847-z
Autor:
Gian Paolo Fadini, C. Pintus, G. Pantè, M. Krampera, Augusto Pessina, Gianluca Ciardelli, Piero Marchetti, Silvia Pellegrini, Valeria Sordi, Lorenzo Piemonti
Publikováno v:
Nutrition, Metabolism and Cardiovascular Diseases
Background The advancement of knowledge in the field of regenerative medicine is increasing the therapeutic expectations of patients and clinicians on cell therapy approaches. Within these, stem cell therapies are often evoked as a possible therapeut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1605b047dc3530cdcca0bece80a72cd
Autor:
Rohit N. Kulkarni, Alfredo Pontecorvi, Gian Pio Sorice, Andrea Giaccari, Gennaro Clemente, Jens J. Holst, Giovanna Muscogiuri, Jiang Hu, Teresa Mezza
Publikováno v:
Diabetes
Type 2 diabetes is characterized by poor glucose uptake in metabolic tissues and manifests when insulin secretion fails to cope with worsening insulin resistance. In addition to its effects on skeletal muscle, liver, and adipose tissue metabolism, it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1145e717731d2908b39e2d0b6181cbe
http://europepmc.org/articles/PMC3931397
http://europepmc.org/articles/PMC3931397