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Plasma Branched-Chain Amino Acids Are Associated With Greater Fasting and Postprandial Insulin Secretion in Non-diabetic Chinese Adults

Autor: Cherlyn Ding, Leonie Egli, Nabil Bosco, Lijuan Sun, Hui Jen Goh, Khung Keong Yeo, Jonathan Jiunn Liang Yap, Lucas Actis-Goretta, Melvin Khee-Shing Leow, Faidon Magkos

Publikováno v: Frontiers in Nutrition, Vol 8 (2021)

Background: Plasma branched-chain amino acids (BCAA) are consistently elevated in subjects with obesity and type 2 diabetes (T2DM) and correlate with insulin resistance. The association of BCAA with insulin secretion and clearance rates has not been

Externí odkaz: https://doaj.org/article/e2aed53bece24f7884b11461fc794d5b

A low n‐6 to n‐3 polyunsaturated fatty acid ratio diet improves hyperinsulinaemia by restoring insulin clearance in obese youth

Autor: Domenico Tricò, Alfonso Galderisi, Michelle A. Van Name, Sonia Caprio, Stephanie Samuels, Zhongyao Li, Brittany T. Galuppo, Mary Savoye, Andrea Mari, Ariel E. Feldstein, Nicola Santoro

Publikováno v: Diabetes, Obesity and Metabolism. 24:1267-1276

To examine the determinants and metabolic impact of the reduction in fasting and postload insulin levels after a low n-6 to n-3 polyunsaturated fatty acid (PUFA) ratio diet in obese youth.Insulin secretion and clearance were assessed by measuring and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7af7bcccc339a5eb9616b7c7635bf2bb
https://doi.org/10.1111/dom.14695

CBL/CAP Is Essential for Mitochondria Respiration Complex I Assembly and Bioenergetics Efficiency in Muscle Cells

Autor: Cho-Cho Aye, Dean E. Hammond, Sergio Rodriguez-Cuenca, Mary K. Doherty, Phillip D. Whitfield, Marie M. Phelan, Chenjing Yang, Rafael Perez-Perez, Xiaoxin Li, Angels Diaz-Ramos, Gopal Peddinti, Matej Oresic, Antonio Vidal-Puig, Antonio Zorzano, Cristina Ugalde, Silvia Mora

Publikováno v: International Journal of Molecular Sciences
Volume 24
Issue 4
Pages: 3399
Aye, C C, Hammond, D E, Rodriguez-Cuenca, S, Doherty, M K, Whitfield, P D, Phelan, M M, Yang, C, Perez-Perez, R, Li, X, Diaz-Ramos, A, Peddinti, G, Oresic, M, Vidal-Puig, A, Zorzano, A, Ugalde, C & Mora, S 2023, ' CBL/CAP Is Essential for Mitochondria Respiration Complex I Assembly and Bioenergetics Efficiency in Muscle Cells ', International Journal of Molecular Sciences, vol. 24, no. 4, 3399 . https://doi.org/10.3390/ijms24043399

Peer reviewed: True
Funder: European Regional Development Fund
Funder: Scottish Funding Council
Funder: Highlands and Islands Enterprise
CBL is rapidly phosphorylated upon insulin receptor activation. Mice whole body CBL depletion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::104678bf02f7ae0237dddc96970d23f3
https://www.repository.cam.ac.uk/handle/1810/347194

Identification of biomarkers for glycaemic deterioration in type 2 diabetes

Autor: Roderick C. Slieker, Louise A. Donnelly, Elina Akalestou, Livia Lopez-Noriega, Rana Melhem, Ayşim Güneş, Frederic Abou Azar, Alexander Efanov, Eleni Georgiadou, Hermine Muniangi-Muhitu, Mahsa Sheikh, Giuseppe N. Giordano, Mikael Åkerlund, Emma Ahlqvist, Ashfaq Ali, Karina Banasik, Søren Brunak, Marko Barovic, Gerard A. Bouland, Frédéric Burdet, Mickaël Canouil, Iulian Dragan, Petra J. M. Elders, Celine Fernandez, Andreas Festa, Hugo Fitipaldi, Phillippe Froguel, Valborg Gudmundsdottir, Vilmundur Gudnason, Mathias J. Gerl, Amber A. van der Heijden, Lori L. Jennings, Michael K. Hansen, Min Kim, Isabelle Leclerc, Christian Klose, Dmitry Kuznetsov, Dina Mansour Aly, Florence Mehl, Diana Marek, Olle Melander, Anne Niknejad, Filip Ottosson, Imre Pavo, Kevin Duffin, Samreen K. Syed, Janice L. Shaw, Over Cabrera, Timothy J. Pullen, Kai Simons, Michele Solimena, Tommi Suvitaival, Asger Wretlind, Peter Rossing, Valeriya Lyssenko, Cristina Legido Quigley, Leif Groop, Bernard Thorens, Paul W. Franks, Gareth E. Lim, Jennifer Estall, Mark Ibberson, Joline W. J. Beulens, Leen M ’t Hart, Ewan R. Pearson, Guy A. Rutter

Publikováno v: Slieker, R C, Donnelly, L A, Akalestou, E, Lopez-Noriega, L, Melhem, R, Güneş, A, Abou Azar, F, Efanov, A, Georgiadou, E, Muniangi-Muhitu, H, Sheikh, M, Giordano, G N, Åkerlund, M, Ahlqvist, E, Ali, A, Banasik, K, Brunak, S, Barovic, M, Bouland, G A, Burdet, F, Canouil, M, Dragan, I, Elders, P J M, Fernandez, C, Festa, A, Fitipaldi, H, Froguel, P, Gudmundsdottir, V, Gudnason, V, Gerl, M J, van der Heijden, A A, Jennings, L L, Hansen, M K, Kim, M, Leclerc, I, Klose, C, Kuznetsov, D, Mansour Aly, D, Mehl, F, Marek, D, Melander, O, Niknejad, A, Ottosson, F, Pavo, I, Duffin, K, Syed, S K, Shaw, J L, Cabrera, O, Pullen, T J, Simons, K, Solimena, M, Suvitaival, T, Wretlind, A, Rossing, P, Lyssenko, V, Legido Quigley, C, Groop, L, Thorens, B, Franks, P W, Lim, G E, Estall, J, Ibberson, M, Beulens, J W J, 't Hart, L M, Pearson, E R & Rutter, G A 2023, ' Identification of biomarkers for glycaemic deterioration in type 2 diabetes ', Nature Communications, vol. 14, 2533 . https://doi.org/10.1038/s41467-023-38148-7
Slieker, R C, Donnelly, L A, Akalestou, E, Lopez-Noriega, L, Melhem, R, Güneş, A, Abou Azar, F, Efanov, A, Georgiadou, E, Muniangi-Muhitu, H, Sheikh, M, Giordano, G N, Åkerlund, M, Ahlqvist, E, Ali, A, Banasik, K, Brunak, S R, Barovic, M, Bouland, G A, Burdet, F, Canouil, M, Dragan, I, Elders, P J M, Fernandez, C, Festa, A, Fitipaldi, H, Froguel, P, Gudmundsdottir, V, Gudnason, V, Gerl, M J, van der Heijden, A A, Jennings, L L, Hansen, M K, Kim, M, Leclerc, I, Klose, C, Kuznetsov, D, Mansour Aly, D, Mehl, F, Marek, D, Melander, O, Niknejad, A, Ottosson, F, Pavo, I, Duffin, K, Syed, S K, Shaw, J L, Cabrera, O, Pullen, T J, Simons, K, Solimena, M, Suvitaival, T, Wretlind, A, Rossing, P, Lyssenko, V, Legido Quigley, C, Groop, L, Thorens, B, Franks, P W, Lim, G E, Estall, J, Ibberson, M, Beulens, J W J, ’t Hart, L M, Pearson, E R & Rutter, G A 2023, ' Identification of biomarkers for glycaemic deterioration in type 2 diabetes ', Nature Communications, vol. 14, no. 1, 2533 . https://doi.org/10.1038/s41467-023-38148-7
Nature Communications, 14(1):2533. Nature Publishing Group UK

We identify biomarkers for disease progression in three type 2 diabetes cohorts encompassing 2,973 individuals across three molecular classes, metabolites, lipids and proteins. Homocitrulline, isoleucine and 2-aminoadipic acid, eight triacylglycerol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa1654ea5cf5cf5976c8684f5b8cb7ed
https://curis.ku.dk/portal/da/publications/identification-of-biomarkers-for-glycaemic-deterioration-in-type-2-diabetes(32aaa1f9-fa85-4d91-83f7-6715b74bca9e).html