Zobrazeno 1 - 10 of 553 pro vyhledávání: '"Insulin/pharmacology"'
1
Ketone Body Infusion abrogates Growth Hormone Induced Lipolysis and Insulin Resistance
Autor: Morten Lyng Høgild, Astrid Johannesson Hjelholt, Jakob Hansen, Steen Bønløkke Pedersen, Niels Møller, Jørgen F P Wojtaszewski, Mogens Johannsen, Niels Jessen, Jens Otto Lunde Jørgensen
Publikováno v: Høgild, M L, Hjelholt, A J, Hansen, J, Pedersen, S B, Møller, N, Wojtaszewski, J F P, Johannsen, M, Jessen, N & Lunde Jørgensen, J O 2023, ' Ketone Body Infusion abrogates Growth Hormone Induced Lipolysis and Insulin Resistance ', The Journal of clinical endocrinology and metabolism, vol. 108, no. 3, pp. 653-664 . https://doi.org/10.1210/clinem/dgac595
ContextExogenous ketone body administration lowers circulating glucose levels but the underlying mechanisms are uncertain.ObjectiveWe tested the hypothesis that administration of the ketone body β-hydroxybutyrate (βOHB) acutely increases insulin se
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fc20c68c3b3f387aa99e20d1ebe736c
https://pure.au.dk/portal/da/publications/ketone-body-infusion-abrogates-growth-hormone-induced-lipolysis-and-insulin-resistance(ea7429e3-b1dd-45fe-a47e-1448b31bab75).html
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2
Akademický článek
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3
3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening
Autor: Alicia Oshlack, Belinda Phipson, Pei Xuan Er, Lorna J Hale, Salman Hosawi, Rachel Lennon, Sara E. Howden, Kynan T. Lawlor, Sean B. Wilson, Irene M. Ghobrial, Andrew Lonsdale, Catherine Quinlan, Melissa H. Little, Shahnaz Khan
Publikováno v: Nature Communications
Hale, L J, Howden, S E, Phipson, B, Lonsdale, A, Er, P X, Ghobrial, I, Hosawi, S, Wilson, S, Lawlor, K T, Khan, S, Oshlack, A, Quinlan, C, Lennon, R & Little, M H 2018, ' 3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening ', Nature Communications, vol. 9, no. 1, pp. 5167 . https://doi.org/10.1038/s41467-018-07594-z
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
The podocytes within the glomeruli of the kidney maintain the filtration barrier by forming interdigitating foot processes with intervening slit diaphragms, disruption in which results in proteinuria. Studies into human podocytopathies to date have e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35740a0d1756c89caeb588587244b788
http://europepmc.org/articles/PMC6279764
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4
Insulin Downregulates the Transcriptional Coregulator CITED2, an Inhibitor of Proangiogenic Function in Endothelial Cells
Autor: Thomas Rathjen, Michael T. Watkins, Samuel M. Lockhart, Lars Melholt Rasmussen, Xuanchun Wang, Simone Rørdam Preil, Ditte Sørensen, Nishant Dwivedi, Brian T. O’Neill, Sally L. Dunwoodie, Hassan Albadawi, Christian Rask-Madsen, Hans Christian Beck
Publikováno v: Diabetes
Wang, X, Lockhart, S M, Rathjen, T, Albadawi, H, Sørensen, D, O'Neill, B T, Dwivedi, N, Rørdam Preil, S, Beck, H C, Dunwoodie, S L, Watkins, M T, Rasmussen, L M & Rask-Madsen, C 2016, ' Insulin Downregulates the Transcriptional Coregulator CITED2, an Inhibitor of Proangiogenic Function in Endothelial Cells ', Diabetes, vol. 65, no. 12, pp. 3680-3690 . https://doi.org/10.2337/db16-0001
In patients with atherosclerotic complications of diabetes, impaired neovascularization of ischemic tissue in the myocardium and lower limb limits the ability of these tissues to compensate for poor perfusion. We identified 10 novel insulin-regulated
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b74d4d9ab5bab1543594bb3917cd4aab
http://europepmc.org/articles/PMC5127242
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5
Dissertation/ Thesis
Single-chain insulin analogs as ultra-stable therapeutics and as models of protein (mis)folding: stability, structure, dynamics, and function of novel analogs
Autor: Glidden, Michael D., II
Single-chain insulin (SCI) analogs have long provided a valuable model for structure-function studies of insulin. Recently, a biologically active SCI containing a six-residue connecting (C) domain (inserted between the B- and A chains of two-chain in
Externí odkaz: http://rave.ohiolink.edu/etdc/view?acc_num=case1522270994798884
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6
Effects of metformin, rosiglitazone and insulin on bone metabolism in patients with type 2 diabetes
Autor: Henning Beck-Nielsen, Kim Brøsen, Jeppe Gram, Niklas Rye Jørgensen, Morten Frost, Mette-Marie Hougaard Christensen, Tore Bjerregaard Stage
Publikováno v: Stage, T B, Christensen, M-M H, Jørgensen, N R, Beck-Nielsen, H, Brøsen, K, Gram, J & Frost, M 2018, ' Effects of metformin, rosiglitazone and insulin on bone metabolism in patients with type 2 diabetes ', Bone, vol. 112, pp. 35-41 . https://doi.org/10.1016/j.bone.2018.04.004
BACKGROUND: Fracture risk is increased in individuals with type 2 diabetes (T2D). The pathophysiological mechanisms accentuating fracture risk in T2D are convoluted, incorporating factors such as hyperglycaemia, insulinopenia, and antidiabetic drugs.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b5e526d85739b5b5a7d7d0ae4581eb0
https://curis.ku.dk/ws/files/222320195/1_s2.0_S8756328218301509_main.pdf
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7
Subzero nonfreezing storage of rat hepatocytes using UW solution and 1,4-butanediol. II- functional testing on rewarming and gene expression of urea cycle enzymes
Autor: Edgardo E. Guibert, María Dolores Pizarro, Luciana L. Almada, Joaquín V. Rodríguez, María E. Mamprin, Cristina Bellarosa, Claudio Tiribelli
Publikováno v: Annals of Hepatology, Vol 8, Iss 2, Pp 129-133 (2009)
In the present study we have analyzed the viability and metabolic competence of isolated rat hepatocytes subjected first, to subzero nonfreezing storage (up to 120 h at -4 degrees C) in modified University of Wisconsin (UW) solution with 8% 1,4-butan
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efe91d865492ca8ecdb28a770084c6b5
http://www.sciencedirect.com/science/article/pii/S1665268119317910
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9
p53-upregulated-modulator-of-apoptosis (PUMA) deficiency affects food intake but does not impact on body weight or glucose homeostasis in diet-induced obesity
Autor: Sara A Litwak, Kim Loh, Andreas Strasser, Esteban Nicolas Gurzov, Helen E. Thomas, Jibran A Wali, Claudia Selck, William J Stanley, Evan G Pappas
Publikováno v: Scientific Reports
Scientific reports, 6
BCL-2 proteins have been implicated in the control of glucose homeostasis and metabolism in different cell types. Thus, the aim of this study was to determine the role of the pro-apoptotic BH3-only protein, p53-upregulated-modulator-of-apoptosis (PUM
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2636fb32454440ee72770afbd24bc074
https://pubmed.ncbi.nlm.nih.gov/27033313
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10
Glucagon Responses of Isolated a Cells to Glucose, Insulin, Somatostatin, and Leptin
Autor: Jacques Philippe, Roger H Unger, Lijun Chen
Publikováno v: Endocrine Practice, Vol. 17, No 5 (2011 ) pp. 819-25
To determine whether glucagon suppression by leptin represents a direct effect on α cells rather than an indirect effect mediated via the hypothalamus.We devised an in vitro α-cell suppression assay in cultured hamster InR1G9 cells. InR1G9 hamster
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb24f099021fcfee786a2f25c6be2cd9
https://doi.org/10.4158/ep11101.or
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