Genetic studies of body mass index yield new insights for obesity biology

Autor: Locke, Adam E, Kahali, Bratati, Croteau-Chonka, Damien C, Doney, Alex S F, He, Bing, Heikkilä, Outi, Hietala, Kustaa, Kytö, Janne, Lahermo, Päivi, Lehto, Markku, Österholm, Anne-May, Parkkonen, Maija, Pitkäniemi, Janne, Rosengård-Bärlund, Milla, Eklund, Niina, Saraheimo, Markku, Sarti, Cinzia, Söderlund, Jenny, Soro-Paavonen, Aino, Syreeni, Anna, Thorn, Lena M, Tikkanen, Heikki, Tolonen, Nina, Tryggvason, Karl, Tuomilehto, Jaakko, Estrada, Karol, Wadén, Johan, Gill, Geoffrey V, Prior, Sarah, Guiducci, Candace, Mirel, Daniel B, Taylor, Andrew, Hosseini, Mohsen, Parving, Hans-Henrik, Rossing, Peter, Tarnow, Lise, Eury, Elodie, Ladenvall, Claes, Alhenc-Gelas, François, Lefebvre, Pierre, Rigalleau, Vincent, Roussel, Ronan, Tregouet, David-Alexandre, Maestroni, Anna, Maestroni, Silvia, Falhammar, Henrik, Gu, Tianwei, Folkersen, Lasse, Möllsten, Anna, Cimponeriu, Dan, Mihai, Ioana, Mota, Maria, Mota, Eugen, Serafinceanu, Cristian, Stavarachi, Monica, Hanson, Robert L, Nelson, Robert G, Kretzler, Matthias, Fraser, Ross M, Colhoun, Helen M, Panduru, Nicolae Mircea, Gu, Harvest F, Brismar, Kerstin, Zerbini, Gianpaolo, Hadjadj, Samy, Marre, Michel, Groop, Leif, Lajer, Maria, Bull, Shelley B, Garcia, Melissa E, Waggott, Daryl, Paterson, Andrew D, Savage, David A, Bain, Stephen C, Martin, Finian, Hirschhorn, Joel N, Godson, Catherine, Florez, Jose C, Groop, Per-Henrik, Maxwell, Alexander P, Geller, Frank, Willer, Cristen J, Schmidt, Ellen M, Sengupta, Sebanti, Peloso, Gina M, Gustafsson, Stefan, Kanoni, Stavroula, Ganna, Andrea, Chen, Jin, Buchkovich, Martin L, Mora, Samia, Giedraitis, Vilmantas, Beckmann, Jacques S, Bragg-Gresham, Jennifer L, Chang, Hsing-Y, Demirkan, Ayşe, Den Hertog, Heleen M, Do, Ron, Donnelly, Louise A, Ehret, Georg B, Esko, Tõnu, Feitosa, Mary F, Gigante, Bruna, Ferreira, Teresa, Fischer, Krista, Fontanillas, Pierre, Freitag, Daniel F, Gurdasani, Deepti, Heikkilä, Kauko, Hyppönen, Elina, Isaacs, Aaron, Jackson, Anne U, Esko, Tonu, Go, Alan S, Johansson, Åsa, Johnson, Toby, Kaakinen, Marika, Kettunen, Johannes, Kleber, Marcus E, Li, Xiaohui, Luan, Jian'an, Lyytikäinen, Leo-Pekka, Magnusson, Patrik K E, Mangino, Massimo, Golay, Alain, Mihailov, Evelin, Montasser, May E, Müller-Nurasyid, Martina, Nolte, Ilja M, O'Connell, Jeffrey R, Palmer, Cameron D, Perola, Markus, Petersen, Ann-Kristin, Sanna, Serena, Saxena, Richa, Goodall, Alison H, Service, Susan K, Shah, Sonia, Shungin, Dmitry, Sidore, Carlo, Song, Ci, Strawbridge, Rona J, Surakka, Ida, Tanaka, Toshiko, Teslovich, Tanya M, Thorleifsson, Gudmar, Gordon, Scott D, Van den Herik, Evita G, Voight, Benjamin F, Volcik, Kelly A, Waite, Lindsay L, Wong, Andrew, Wu, Ying, Zhang, Weihua, Absher, Devin, Asiki, Gershim, Barroso, Inês, Gorski, Mathias, Been, Latonya F, Bolton, Jennifer L, Bonnycastle, Lori L, Brambilla, Paolo, Burnett, Mary S, Cesana, Giancarlo, Dimitriou, Maria, Doring, Angela, Elliott, Paul, Grabe, Hans-Jörgen, Epstein, Stephen E, Eyjolfsson, Gudmundur Ingi, 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Nature, 518(7538), 197. Nature Publishing Group
Nature
Nature, 518(7538), 197-U401
Nature, Vol. 518, No 7538 (2015) pp. 197-206
Nature, vol. 518, no. 7538, pp. 197-206
Nature 518(7538), 197-206 (2015). doi:10.1038/nature14177
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Locke, A E, Kahali, B, Berndt, S I, Justice, A E, Pers, T H, Day, F R, Powell, C, Vedantam, S, Buchkovich, M L, Yang, J, Croteau-Chonka, D C, Esko, T, Fall, T, Ferreira, T, Gustafsson, S, Kutalik, Z, Luan, J, Maegi, R, Randall, J C, Winkler, T W, Wood, A R, Workalemahu, T, Faul, J D, Smith, J A, Zhao, J H, Zhao, W, Chen, J, Fehrmann, R, Hedman, A K, Karjalainen, J, Schmidt, E M, Absher, D, Amin, N, Anderson, D, Beekman, M & Bolton, J L & Bragg-Gresham, L & Buyske, S & Demirkan, A & Deng, G & Fraser, R M & Hayward, C & McLachlan, S & Campbell, H & Morris, A D & Price, J F & Rudan, I & Walker, M & Wilson, J F & Visscher, P M 2015, ' Genetic studies of body mass index yield new insights for obesity biology ', Nature, vol. 518, no. 7538, pp. 197-U401 . https://doi.org/10.1038/nature14177
Nature, 518(7538), 197-U401. Nature Publishing Group
Nature, 518, 7538, pp. 197-206
Nature, 518, 197-206

Item does not contain fulltext Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e9c5084ccf8e95018f370ac56cecd0a
https://research.vu.nl/en/publications/58992b26-1689-48dd-bb82-82548598fe61

Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes

Autor: Yunzhao Tang, Ola Hansson, Thomas Reinbothe, Taman Mahdi, Yuedan Zhou, Jonathan M. J. Derry, Valeriya Lyssenko, Jalal Taneera, Leif Groop, Claes B. Wollheim, Xingjun Jing, Albert Salehi, Lena Eliasson, Ulrika Krus, Jonathan L.S. Esguerra, Peter Almgren, Anders Rosengren, Enming Zhang, Erik Renström, Sonja Hänzelmann, Sarheed Jabar Muhammed, Anna M. Blom, Annika S. Axelsson

Publikováno v: Cell Metabolism, Vol. 16, No 5 (2012) pp. 625-33
Cell Metabolism; 16(5), pp 625-633 (2012)

SummaryA plethora of candidate genes have been identified for complex polygenic disorders, but the underlying disease mechanisms remain largely unknown. We explored the pathophysiology of type 2 diabetes (T2D) by analyzing global gene expression in h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::126bd5ad8c16d23d81421a3a35eabee6
http://lup.lub.lu.se/record/3219063/file/3878932.pdf

Increased neuronal nitric oxide synthase dimerisation is involved in rat and human pancreatic beta cell hyperactivity in obesity

Autor: B Nadal, F. Castex, Pascal Pomiès, K. Mezghenna, Pierre Petit, René Gross, J. Leroy, Linda Cambier, Nadja Niclauss, Anne-Dominique Lajoix, Ramon Gomis, C Cazevieille, Thierry Berney, A Chalançon

Publikováno v: Diabetologia, Vol. 54, No 11 (2011) pp. 2856-66

Pancreatic beta cell hyperactivity is known to occur in obesity, particularly in insulin-resistant states. Our aim was to investigate whether changes in neuronal nitric oxide synthase (nNOS) function affect beta cell compensation in two relevant mode

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f575cc0dfefb7329d77efecea4a33f7
https://pubmed.ncbi.nlm.nih.gov/21847584

Pdx1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppression

Autor: Chunhua Dai, Andreas Wiederkehr, Benoit R. Gauthier, Jorge Ferrer, Mathurin Baquié, Claes B. Wollheim, Alvin C. Powers, Raymond J. MacDonald, François Pattou, Julie Kerr-Conte

Publikováno v: Cell Metabolism
Cell Metabolism, Vol. 10, No 2 (2009) pp. 110-8

Mutations in the transcription factor Pdx1 cause maturity-onset diabetes of the young 4 (MODY4). Islet transduction with dominant-negative Pdx1 (RIPDN79PDX1) impairs mitochondrial metabolism and glucose-stimulated insulin secretion (GSIS). Transcript

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b348a0310dbbf79726e44752b5cb400a
https://europepmc.org/articles/PMC4012862/

MicroRNAs: 'ribo-regulators' of glucose homeostasis

Autor: Benoit R. Gauthier, Claes B. Wollheim

Publikováno v: Nature Medicine, Vol. 12, No 1 (2006) pp. 36-8

Insulin secretion regulates glucose homeostasis and its dysregulation causes type 2 diabetes. Short noncoding microRNAs have now been shown to control exocytosis, the final event in insulin secretion. This discovery opens potential perspectives for d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ab7680c289dea0a381ddf31818b7059
https://archive-ouverte.unige.ch/unige:34528