Zobrazeno 1 - 10
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pro vyhledávání: '"Insulator Element"'
Akademický článek
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Autor:
Miao Yu, Bing Ren, Andrea M. Chiariello, Yuanyuan Han, Mattia Conte, Adam Jussila, Yanxiao Zhang, Quan Zhu, Ivan Juric, Xiaowei Zhuang, Hui Huang, Bogdan Bintu, Melodi Tastemel, Ming Hu, Mario Nicodemi, Simona Bianco, Rong Hu, Colin Kern
Publikováno v:
Nat Genet
Insulators play a critical role in spatiotemporal gene regulation in animals. The evolutionarily conserved CCCTC-binding factor (CTCF) is required for insulator function in mammals, but not all of its binding sites act as insulators. Here we explore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfc9e7bffe1b5edbfcc0503170f90f65
http://hdl.handle.net/11588/863501
http://hdl.handle.net/11588/863501
Autor:
Titus Ponrathnam, Rakesh Mishra
Publikováno v:
The Nucleus. 61:227-234
The nucleus of every cell is arranged in a manner that reflects the cell’s functional identity. Its DNA loops around histones that help compact and regulate the local functional state. Various other proteins along with RNAs are arranged along the D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2cb9b4232ee063ad913dcc9fa766976
https://doi.org/10.1007/s13237-018-0242-y
https://doi.org/10.1007/s13237-018-0242-y
Autor:
Panagiotis Ntziachristos, Aristotelis Tsirigos, Theodore Sakellaropoulos, Aurelie C. Lozano, Prabhanjan Kambadur, Charalampos Lazaris, Iannis Aifantis, Yixiao Gong
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
NATURE COMMUNICATIONS
Nature Communications
NATURE COMMUNICATIONS
Nature Communications
The metazoan genome is compartmentalized in areas of highly interacting chromatin known as topologically associating domains (TADs). TADs are demarcated by boundaries mostly conserved across cell types and even across species. However, a genome-wide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4466590d548bbc8f0ab562476d03c27
http://link.springer.com/article/10.1038/s41467-018-03017-1
http://link.springer.com/article/10.1038/s41467-018-03017-1
Publikováno v:
Genome Biology and Evolution
Chromosomal inversions are among the primary drivers of genome structure evolution in a wide range of natural populations. Although there is an impressive array of theory and empirical analyses that have identified conditions under which inversions c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f60a2f679954cba7648d7532c504be7d
https://doi.org/10.1101/793364
https://doi.org/10.1101/793364
Autor:
Dahong Chen, Elissa P. Lei
Publikováno v:
Curr Opin Cell Biol
Chromatin insulators are DNA-protein complexes that play a crucial role in regulating chromatin organization. Within the past two years, a plethora of genome-wide conformation capture studies have helped reveal that insulators are necessary for prope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93d380a21c15dfc9879283c7eea489d7
https://europepmc.org/articles/PMC6692201/
https://europepmc.org/articles/PMC6692201/
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0176013 (2017)
PLoS ONE
PLoS ONE
Variation in the DNA sequence upstream of bacterial promoters is known to affect the expression levels of the products they regulate, sometimes dramatically. While neutral synthetic insulator sequences have been found to buffer promoters from upstrea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::852319cf02c5a1524d9e5ec6e96121b2
http://europepmc.org/articles/PMC5396932?pdf=render
http://europepmc.org/articles/PMC5396932?pdf=render
Publikováno v:
BioEssays. 36:163-172
Insulators play a central role in subdividing the chromosome into a series of discrete topologically independent domains and in ensuring that enhancers and silencers contact their appropriate target genes. In this review we first discuss the general
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a3601600c8080397df2a698467b0a7a
https://doi.org/10.1002/bies.201300125
https://doi.org/10.1002/bies.201300125
Publikováno v:
The Journal of Cell Biology
Insulator bodies are novel nuclear stress foci that can be used as a proxy to monitor the chromatin-bound state of insulator proteins.
Chromatin insulators assist in the formation of higher-order chromatin structures by mediating long-range cont
Chromatin insulators assist in the formation of higher-order chromatin structures by mediating long-range cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::676196147acd37da84f823614d3ad6b3
http://europepmc.org/articles/PMC3718971
http://europepmc.org/articles/PMC3718971
Autor:
Maxim Imakaev, Geoffrey Fudenberg, Anton Goloborodko, Carolyn Lu, Nezar Abdennur, Leonid A. Mirny
Publikováno v:
Cell Reports, Vol 15, Iss 9, Pp 2038-2049 (2016)
Cell Reports
Cell Reports
Topologically associating domains (TADs) are fundamental structural and functional building blocks of human interphase chromosomes, yet the mechanisms of TAD formation remain unclear. Here, we propose that loop extrusion underlies TAD formation. In t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8e18951db251721d8682dec5cc138ca
https://europepmc.org/articles/PMC4889513/
https://europepmc.org/articles/PMC4889513/