Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Insoluble Tau"'
Autor:
Kerstin Schlegel, Khader Awwad, Roland G. Heym, David Holzinger, Annika Doell, Stefan Barghorn, Thomas R. Jahn, Corinna Klein, Yulia Mordashova, Michael Schulz, Laura Gasparini
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-15 (2019)
Abstract Intraneuronal insoluble inclusions made of Tau protein are neuropathological hallmarks of Alzheimer Disease (AD). Cleavage of Tau by legumain (LGMN) has been proposed to be crucial for aggregation of Tau into fibrils. However, it remains unc
Externí odkaz:
https://doaj.org/article/daa0b3da5ac64eacac47f030b3004bf8
Autor:
Jennifer A. Macdonald, Iraad F. Bronner, Lesley Drynan, Juan Fan, Annabelle Curry, Graham Fraser, Isabelle Lavenir, Michel Goedert
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-11 (2019)
Abstract A pathological pathway leading from soluble monomeric to insoluble filamentous Tau is characteristic of many human neurodegenerative diseases, which also exhibit dysfunction and death of brain cells. However, it is unknown how the assembly o
Externí odkaz:
https://doaj.org/article/b5e78336638247b6b7a93dfe965c6c2a
Autor:
Gen Matsumoto, Kazuki Matsumoto, Taeko Kimura, Tetsuya Suhara, Makoto Higuchi, Naruhiko Sahara, Nozomu Mori
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 5, p 1497 (2018)
Neurofibrillary tangles composed of hyperphosphorylated tau protein are primarily neuropathological features of a number of neurodegenerative diseases collectively termed tauopathy. To understand the mechanisms underlying the cause of tauopathy, prec
Externí odkaz:
https://doaj.org/article/6e9f74afc9aa40ea97377bcaa55b5a02
Akademický článek
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Kniha
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Autor:
Catherine M Cowan, Amrit eMudher
Publikováno v:
Frontiers in Neurology, Vol 4 (2013)
Aggregation of highly-phosphorylated tau into aggregated forms such as filaments and neurofibrillary tangles is one of the defining pathological hallmarks of Alzheimer’s disease and other tauopathies. Hence therapeutic strategies have focused on in
Externí odkaz:
https://doaj.org/article/e4b59c09bc3a43b3960eaf2f334e45dd
Autor:
Giuseppe Federico Amodeo, David Klenerman, Noemí Esteras, Franziska Kundel, Andrey Y. Abramov, Evgeny Pavlov
Most neurodegenerative disorders are associated with aggregation and accumulation of misfolded proteins. One of these proteins, tau, is involved in a number of pathologies including Alzheimer's disease and frontotemporal dementia. Aggregation and pho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d9ee54aed8c7809200a92fadd01c102
https://www.repository.cam.ac.uk/handle/1810/305249
https://www.repository.cam.ac.uk/handle/1810/305249
Autor:
Laura Gasparini, Khader Awwad, Stefan Barghorn, Thomas R. Jahn, Annika Doell, Yulia Mordashova, Kerstin Schlegel, David Holzinger, Roland G. Heym, Michael Schulz, Corinna Klein
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-15 (2019)
Acta Neuropathologica Communications
Acta Neuropathologica Communications
Intraneuronal insoluble inclusions made of Tau protein are neuropathological hallmarks of Alzheimer Disease (AD). Cleavage of Tau by legumain (LGMN) has been proposed to be crucial for aggregation of Tau into fibrils. However, it remains unclear if L
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Graham Fraser, Juan Fan, Isabelle Lavenir, Michel Goedert, Jennifer A. Macdonald, Annabelle Curry, Lesley F Drynan, Iraad F. Bronner
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-11 (2019)
Acta Neuropathologica Communications
Acta Neuropathologica Communications
A pathological pathway leading from soluble monomeric to insoluble filamentous Tau is characteristic of many human neurodegenerative diseases, which also exhibit dysfunction and death of brain cells. However, it is unknown how the assembly of Tau int