Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Insil Kim"'
Autor:
Timothy A. Yap, Siddhartha Yadav, Benjamin Herzberg, Benedito A. Carneiro, Elisa Fontana, Martin Højgaard, Michael J. Pishvaian, Ruth Plummer, Theresa L. Werner, Vaibhav Sahai, Stephanie Lheureux, Elizabeth K. Lee, Niharika B. Mettu, Gregory M. Cote, Joseph D. Schonhoft, Victoria Rimkunas, Ian M. Silverman, Marisa Wainszelbaum, Gerson Peltz, Adrian J. Fretland, Kezhen Fei, Danielle Ulanet, Insil Kim, Maria Koehler, Ezra Rosen, Michael Cecchini
Publikováno v:
Cancer Research. 83:CT018-CT018
Introduction: ATRi and PARPi combinations kill tumor cells via synergistic modulation of complementary DDR pathways but clinical utility is limited by overlapping toxicities. A genome-wide CRISPR-Cas9 screen identified DDR alterations that sensitize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5440534684331a320c7059e7bfb12f85
https://doi.org/10.1158/1538-7445.am2023-ct018
https://doi.org/10.1158/1538-7445.am2023-ct018
Publikováno v:
Angle Orthod
Lower incisor extraction is an effective option for treating lower anterior crowding in patients with a good facial profile, Class I molar occlusion, and narrow upper incisors. This report describes the successful treatment of an adolescent patient w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::904875276b524d22b51a420c8325a42f
https://pubmed.ncbi.nlm.nih.gov/30080123
https://pubmed.ncbi.nlm.nih.gov/30080123
Autor:
Elizabeth S. Didier, Miguel Coelho, Iain Ridgway, Tracy T. Chow, Paul W. Whitby, Insil Kim, Eva E. R. Philipp, Philip McQuary, William E. Sonntag, Courtney M. Campbell, Sara Gelino, Zoltan Ungvari, Marissa A. Holmbeck, Danuta Sosnowska, Anna Csiszar, Steven N. Austad, Erik Levy
Publikováno v:
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 68:359-367
Bivalve species with exceptional longevity are newly introduced model systems in biogerontology to test evolutionarily conserved mechanisms of aging. Here, we tested predictions based on the oxidative stress hypothesis of aging using one of the tropi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba6fe9f002bc70dba00985f80a47df37
https://doi.org/10.1093/gerona/gls159
https://doi.org/10.1093/gerona/gls159
Autor:
Insil Kim, Eva E. R. Philipp, Sara Gelino, Philip McQuary, Danuta Sosnowska, Steven N. Austad, William E. Sonntag, Tracy T. Chow, Elizabeth S. Didier, Iain Ridgway, Marissa A. Holmbeck, Zoltan Ungvari, Anna Csiszar, Erik Levy, Miguel Coelho, Courtney M. Campbell
Publikováno v:
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. :741-750
We assess whether reactive oxygen species production and resistance to oxidative stress might be causally involved in the exceptional longevity exhibited by the ocean quahog Arctica islandica. We tested this hypothesis by comparing reactive oxygen sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebb9b4a9fc469074e78fea0c69591c4a
https://doi.org/10.1093/gerona/glr044
https://doi.org/10.1093/gerona/glr044
Autor:
Elisabetta Viani Puglisi, R. Andrew Marshall, Darrin A. Lindhout, Sean A. McKenna, Insil Kim, Colin Echeverría Aitken, Joseph D. Puglisi
Publikováno v:
Nature Protocols. 2:3270-3277
RNA synthesis using in vitro transcription by phage T7 RNA polymerase allows preparation of milligram quantities of RNA for biochemical, biophysical and structural investigations. Previous purification approaches relied on gel electrophoretic or grav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::249d491dd16797d3fe978d76f6103e61
https://doi.org/10.1038/nprot.2007.480
https://doi.org/10.1038/nprot.2007.480
Publikováno v:
RNA. 13:289-294
We present here an improved RNA purification method using fast performance liquid chromatography (FPLC) size-exclusion chromatography in place of denaturing polyacrylamide gel electrophoresis (PAGE). The method allows preparation of milligram quantit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0ef4730954b76ba8a6090df150f393e
https://doi.org/10.1261/rna.342607
https://doi.org/10.1261/rna.342607
Publikováno v:
Journal of Molecular Biology. 358:430-442
PKR (double-stranded RNA-dependent protein kinase) is an important component of host defense to virus infection. Binding of dsRNA to two dsRBDs (double-stranded RNA binding domains) of PKR modulates its own kinase activation. How structural features
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::517ddf8ff29eac1885305ba45ca21a2a
https://doi.org/10.1016/j.jmb.2006.01.099
https://doi.org/10.1016/j.jmb.2006.01.099
Publikováno v:
Nature Structural & Molecular Biology. 10:1033-1038
Complex RNA structures regulate many biological processes, but are often too large for structure determination by NMR methods. The 5' untranslated region (5' UTR) of the hepatitis C viral (HCV) RNA genome contains an internal ribosome entry site (IRE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7208917ebde71733e16c9ac1e027ce30
https://doi.org/10.1038/nsb1004
https://doi.org/10.1038/nsb1004
Autor:
Tan Inoue, Yutaka Muto, Yoichi Nishiya, Insil Kim, Hiroshi Takaku, Kimitsuna Watanabe, Toshimasa Yamazaki, Kazumi Hosono, Shigeyuki Yokoyama, Etsuko Katoh, Takashi Ohtsuki, Satoru Watanabe, Kensaku Sakamoto, Aya Kitamura, Gota Kawai, Takuhiro Ito
Publikováno v:
RNA. 8:440-451
In the second step of the two consecutive transesterifications of the self-splicing reaction of the group I intron, the conserved guanosine at the 3' terminus of the intron (omegaG) binds to the guanosine-binding site (GBS) in the intron. In the pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93ec02a818a5d31032097bf851bc918f
https://doi.org/10.1017/s1355838202026043
https://doi.org/10.1017/s1355838202026043
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(49)
Axonal degeneration occurs in multiple neurodegenerative disorders of the central and peripheral nervous system. Although the underlying molecular pathways leading to axonal degeneration are incompletely understood, accumulating evidence suggests con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::038f20d570baad0840a6f8d92a1c40dc
https://pubmed.ncbi.nlm.nih.gov/24305821
https://pubmed.ncbi.nlm.nih.gov/24305821