Výsledky vyhledávání - "InsR, insulin receptor"

S-Allylmercaptocysteine improves alcoholic liver disease partly through a direct modulation of insulin receptor signaling

Autor: Pingping Luo, Rui Zhang, Qian Yu, George L. Tipoe, Ming Zheng, Xiaoming Sun, Yingxia Liu, Jia Xiao, Wei Li, Hong Zhang

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 668-679 (2021)

Alcoholic liver disease (ALD) causes insulin resistance, lipid metabolism dysfunction, and inflammation. We investigated the protective effects and direct regulating target of S-allylmercaptocysteine (SAMC) from aged garlic on liver cell injury. A ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f71348640a2921fa24860e2b42b33f51
http://europepmc.org/articles/PMC7982498

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Purification of ginseng rare sapogenins 25-OH-PPT and its hypoglycemic, antiinflammatory and lipid-lowering mechanisms

Autor: Guangyue Su, Yuqing Zhao, Xiuli Bi, Meng Ding, Wei Wang, Jing Xu, Jincai Lu, Hairong Liu

Publikováno v: Journal of Ginseng Research
Journal of Ginseng Research, Vol 45, Iss 1, Pp 86-97 (2021)

Background Panax ginseng Meyer has been used as a nourishing edible herb in East Asia for thousands of years. 25-OH-PPT was first discovered as a natural rare triterpenoid saponin in ginseng stems and leaves by our group. Research found that it showe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c205e525f18082f7d4e4f4b4764f01b
http://europepmc.org/articles/PMC7791145

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The steroid hormone 20-hydroxyecdysone counteracts insulin signaling via insulin receptor dephosphorylation

Autor: Yan-Li Li, You-Xiang Yao, Yu-Qin Di, Yu-Meng Zhao, Xiao-Fan Zhao

Publikováno v: The Journal of Biological Chemistry

The insulin receptor (INSR) binds insulin to promote body growth and maintain normal blood glucose levels. While it is known that steroid hormones such as estrogen and 20-hydroxyecdysone counteract insulin function, the molecular mechanisms responsib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cd596f55ed83bd0f07cbb0e2d90f85b
https://pubmed.ncbi.nlm.nih.gov/33484713

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Growth hormone receptor-deficient pigs resemble the pathophysiology of human Laron syndrome and reveal altered activation of signaling cascades in the liver

Autor: Martin Bidlingmaier, Birgit Rathkolb, Martin Hrabĕ de Angelis, Arne Hinrichs, Werner F. Blum, Sebastian Bultmann, Heinrich Leonhardt, Maik Dahlhoff, Simone Renner, Andreas Blutke, Eckhard Wolf, Barbara Kessler, Andreas Hoeflich, Hiroshi Nagashima, Maren Bernau, Mayuko Kurome, Rüdiger Wanke, Elisabeth Kemter, Armin M. Scholz

Publikováno v: Molecular Metabolism, Vol 11, Iss, Pp 113-128 (2018)
Molecular Metabolism
Mol. Metab. 11, 113-128 (2018)
Molecular metabolism, 11: 113-128

Objective Laron syndrome (LS) is a rare, autosomal recessive disorder in humans caused by loss-of-function mutations of the growth hormone receptor (GHR) gene. To establish a large animal model for LS, pigs with GHR knockout (KO) mutations were gener

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75c4a72923ebcdfb6d5ba81facbff4eb
http://www.sciencedirect.com/science/article/pii/S2212877818302114

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A high-fat diet catalyzes progression to hyperglycemia in mice with selective impairment of insulin action in Glut4-expressing tissues

Autor: Daniel J. Horan, Hyun Cheol Roh, Aaron C. Ericsson, Surabhi D. Abhyankar, Natalie D. Stull, Xiaocheng C. Dong, Alexander G. Robling, Hongxia Ren, Robert N. Bone, Austin M. Reilly, Shijun Yan, Jason M. Conley, Carmella Evans-Molina, Menghao Huang

Publikováno v: The Journal of Biological Chemistry

Insulin resistance impairs postprandial glucose uptake through glucose transporter type 4 (GLUT4) and is the primary defect preceding type 2 diabetes. We previously generated an insulin-resistant mouse model with human GLUT4 promoter-driven insulin r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3a1f584191ae8f0764e128eed5d78d0
https://doi.org/10.1016/j.jbc.2021.101431

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Akademický článek

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Akademický článek

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Redox implications in adipose tissue (dys)function—A new look at old acquaintances

Autor: Aleksandra Korac, Ana Stancic, Vesna Otasevic, Biljana Buzadzic, Aleksandra Jankovic, Bato Korac, Andreas Daiber

Publikováno v: Redox Biology

Obesity is an energy balance disorder associated with dyslipidemia, insulin resistance and diabetes type 2, also summarized with the term metabolic syndrome or syndrome X. Increasing evidence points to “adipocyte dysfunction”, rather than fat mas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ee759f35265e55399e90356f4d62a83

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Report

A novel nonsense mutation in the insulin receptor gene in a patient with HAIR-AN syndrome and endometrial cancer.

Autor: Cuenca D; Department of Endocrinology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga #15, Belisario Dominguez, Sección XVI, Tlalpan, 14080 Mexico City, Mexico., Ventura-Gallegos JL; Unit of Biochememistry, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga #15, Belisario Dominguez, Sección XVI, Tlalpan, 14080 Mexico City, Mexico., Almeda-Valdes P; Department of Endocrinology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga #15, Belisario Dominguez, Sección XVI, Tlalpan, 14080 Mexico City, Mexico., Tusié-Luna MT; Unit of Molecular Biology and Genomic Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga #15, Belisario Dominguez, Sección XVI, Tlalpan, 14080, Mexico City, Mexico., Reza-Albarran A; Department of Endocrinology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga #15, Belisario Dominguez, Sección XVI, Tlalpan, 14080 Mexico City, Mexico., Ventura-Ayala L; Unit of Biochememistry, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga #15, Belisario Dominguez, Sección XVI, Tlalpan, 14080 Mexico City, Mexico., Ordoñez-Sánchez ML; Unit of Molecular Biology and Genomic Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga #15, Belisario Dominguez, Sección XVI, Tlalpan, 14080, Mexico City, Mexico., Segura-Kato Y; Unit of Molecular Biology and Genomic Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga #15, Belisario Dominguez, Sección XVI, Tlalpan, 14080, Mexico City, Mexico., Gomez-Perez FJ; Department of Endocrinology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga #15, Belisario Dominguez, Sección XVI, Tlalpan, 14080 Mexico City, Mexico., Conte MP; Department of Endocrinology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga #15, Belisario Dominguez, Sección XVI, Tlalpan, 14080 Mexico City, Mexico., Gonzalez LR; Department of Endocrinology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga #15, Belisario Dominguez, Sección XVI, Tlalpan, 14080 Mexico City, Mexico., Zentella-Dehesa A; Unit of Biochememistry, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga #15, Belisario Dominguez, Sección XVI, Tlalpan, 14080 Mexico City, Mexico.

Publikováno v: Molecular genetics and metabolism reports [Mol Genet Metab Rep] 2023 Mar 13; Vol. 35, pp. 100965. Date of Electronic Publication: 2023 Mar 13 (Print Publication: 2023).

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Akademický článek

Gut microbiota specifically mediates the anti-hypercholesterolemic effect of berberine (BBR) and facilitates to predict BBR's cholesterol-decreasing efficacy in patients.

Autor: Wu C; Pharmacology and Toxicology Research Center, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China., Zhao Y; Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China., Zhang Y; Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China., Yang Y; Pharmacology and Toxicology Research Center, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China., Su W; Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China., Yang Y; Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China., Sun L; Pharmacology and Toxicology Research Center, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China., Zhang F; Pharmacology and Toxicology Research Center, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China., Yu J; Pharmacology and Toxicology Research Center, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China., Wang Y; Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China., Guo P; Pharmacology and Toxicology Research Center, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China., Zhu B; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China., Wu S; Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China.

Publikováno v: Journal of advanced research [J Adv Res] 2021 Jul 30; Vol. 37, pp. 197-208. Date of Electronic Publication: 2021 Jul 30 (Print Publication: 2022).

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