Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Innocent Mushi"'
Binding mode and structure-activity relationships around direct inhibitors of the Nrf2-Keap1 complex
Autor:
Edward Beaumont, Mark A. Brooks, Eric Jnoff, Vincent Anthony Corden, Christophe Genicot, Stephanie Duclos, John J. Barker, Zara A. Sands, Graham Dawson, Oliver Barker, Steven Bromidge, Rosemary Maghames, Claudia Albrecht, Jason Kwong, Jean-Philippe Courade, Tara Fryatt, Richard Pike, Tom Ceska, Frederick Arthur Brookfield, Emilie Jigorel, Innocent Mushi, Christian Bubert, Christopher C. Stimson, Myron A. Smith
Publikováno v:
ChemMedChem. 9(4)
An X-ray crystal structure of Kelch-like ECH-associated protein(Keap1) co-crystallised with (1S,2R)-2-[(1S)-1-[(1,3-dioxo-2,3-di-hydro-1H-isoindol-2-yl)methyl]-1,2,3,4-tetrahydroisoquinolin-2-carbonyl]cyclohexane-1-carboxylic acid (compound (S,R,S)-1
Autor:
Jenkins James Edward, Andreas Ebneth, Doris Riether, Andreas F. Kahrs, Sabine Löbbe, Innocent Mushi, Taylor Malcolm, Kathy O’Shea, Daw-Tsun Shih, Edward Walker, Brian W. Dymock, Monika Ermann, Mark L. Brewer, David S. Thomson, Stephen P. East, Beatriz Noya-Marino, Mark J. Gemkow, Patricia Amouzegh
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(5)
A high-throughput screening campaign resulted in the discovery of a highly potent dual cannabinoid receptor 1 (CB1) and 2 (CB2) agonist. Following a thorough SAR exploration, a series of selective CB2 full agonists were identified.
Autor:
Zara A. Sands, John Barker, Jean-Philippe Courade, Graham Dawson, Edward Beaumont, Oliver Barker, Tara Fryatt, Eric Jnoff, Innocent Mushi, Christopher C. Stimson, Vincent Anthony Corden, Claudia Albrecht, Frederick Arthur Brookfield, Richard Pike, Rosemary Maghames, Tom Ceska, Jason Kwong, Emilie Jigorel, Steven Mark Bromidge, Stephanie Duclos, Christian Bubert, Myron A. Smith, Mark A. Brooks, Christophe Genicot
Publikováno v:
ChemMedChem. 9:674-674