Pax2 Expression Occurs in Renal Medullary Epithelial Cells in vivo and in Cell Culture, Is Osmoregulated, and Promotes Osmotic Tolerance

Autor: Cai, Qi, Dmitrieva, Natalia I., Ferraris, Joan D., Brooks, Heddwen L., Burg, Maurice

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2005 Jan 01. 102(2), 503-508.

Externí odkaz: https://www.jstor.org/stable/3374274

Discovery of novel diarylamides as orally active diuretics targeting urea transporters

Autor: Jia Meng, Yan Zhao, Guangying Shao, Shun Zhang, Zemei Ge, Baoxue Yang, Xiaoqiang Geng, Shuyuan Wang, Yue Xu, Min Li, Jinzhao He, Runtao Li, Guangping Chen, Hong Zhou, Jianhua Ran

Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 1, Pp 181-202 (2021)
Acta Pharmaceutica Sinica. B

Urea transporters (UT) play a vital role in the mechanism of urine concentration and are recognized as novel targets for the development of salt-sparing diuretics. Thus, UT inhibitors are promising for development as novel diuretics. In the present s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b07691ffc571a4d2e747924feb8f8ea3
https://doi.org/10.1016/j.apsb.2020.06.001

Solute and water transport along an inner medullary collecting duct undergoing peristaltic contractions

Autor: Anita T. Layton

Publikováno v: Am J Physiol Renal Physiol

The mechanism by which solutes accumulate in the inner medulla of the mammalian kidney has remained incompletely understood. That persistent mystery has led to hypotheses based on the peristaltic contractions of the pelvic wall smooth muscles. It has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9f4ed15ddab9be3e70dc8e6fae4dd47
https://doi.org/10.1152/ajprenal.00265.2019

Diuretic state affects ascending thin limb tight junctions

Autor: Markus Bleich, Svenja R. Sonntag, Vera C. Wulfmeyer, Nina Himmerkus, Susanne Milatz, Annalisa Ziemens

Publikováno v: American Journal of Physiology-Renal Physiology. 314:F190-F195

The nephron segments in the inner medulla are part of the urine concentrating mechanism. Depending on the diuretic state, they are facing a large range of extracellular osmolality. We investigated whether water homeostasis affects tubular transport a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::038ac08ee77a2d098799b58faeaa0a0e
https://doi.org/10.1152/ajprenal.00419.2017

Renal aquaporins and water balance disorders

Autor: Robert A. Fenton, Cecilia Hvitfeldt Fuglsang, Hanne B. Moeller

Publikováno v: Moeller, H B, Fuglsang, C H & Fenton, R A 2016, ' Renal aquaporins and water balance disorders ', Best Practice & Research: Clinical Endocrinology & Metabolism, vol. 30, no. 2, pp. 277-288 . https://doi.org/10.1016/j.beem.2016.02.012

Aquaporins (AQPs) are a 13 member family (AQP0-12) of proteins that act as channels, through which water and, for some family members, glycerol, urea and other small solutes can be transported. Aquaporins are highly abundant in kidney epithelial cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::769a28028f37bbb59d6a6f567bfa9768
https://doi.org/10.1016/j.beem.2016.02.012