Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Inner ear morphogenesis"'
Autor:
Jie Wen, Jian Song, Yijiang Bai, Yalan Liu, Xinzhang Cai, Lingyun Mei, Lu Ma, Chufeng He, Yong Feng
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Waardenburg syndrome (WS) is an autosomal dominant inherited disorder that is characterized by sensorineural hearing loss and abnormal pigmentation. SOX10 is one of its main pathogenicity genes. The generation of patient-specific induced pluripotent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f595d2d00b931f7ad4a931c6495849b7
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Biblos-e Archivo. Repositorio Institucional de la UAM
Frontiers in Cell and Developmental Biology
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Biblos-e Archivo. Repositorio Institucional de la UAM
Sphingolipids are bioactive lipid components of cell membranes with important signal transduction functions in health and disease. Ceramide is the central building block for sphingolipid biosynthesis and is processed to form structurally and function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aaa09e9b50be7171e1885e3db41021d
https://www.frontiersin.org/articles/10.3389/fcell.2021.678760/full
https://www.frontiersin.org/articles/10.3389/fcell.2021.678760/full
Publikováno v:
Genesis (New York, N.Y. : 2000)REFERENCES. 59(4)
Adhesion GPCRs are important regulators of conserved developmental processes and represent an untapped pool of potential targets for drug discovery. The adhesion GPCR Adgrg6 (Gpr126) has critical developmental roles in Schwann cell maturation and inn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de5f76e6bac5bd10d73bc779362759cb
https://pubmed.ncbi.nlm.nih.gov/33735533
https://pubmed.ncbi.nlm.nih.gov/33735533
Publikováno v:
Viruses, Vol 13, Iss 71, p 71 (2021)
Viruses
Viruses
Hearing loss, one of the most prevalent chronic health conditions, affects around half a billion people worldwide, including 34 million children. The World Health Organization estimates that the prevalence of disabling hearing loss will increase to o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e81858cf57f8e5d7276db6383683240c
https://www.mdpi.com/1999-4915/13/1/71
https://www.mdpi.com/1999-4915/13/1/71
Publikováno v:
Development
The evolutionarily conserved lethal-7 (let-7) microRNAs (miRNAs) are well-known activators of proliferative quiescence and terminal differentiation. However, in the murine auditory organ, let-7g overexpression delays the differentiation of mechano-se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9e1ebb60293c2345b5431fedbcdb25c
https://europepmc.org/articles/PMC7438007/
https://europepmc.org/articles/PMC7438007/
Publikováno v:
Development
Retinoic acid (RA), a vitamin A (retinol) derivative, has pleiotropic functions during embryonic development. The synthesis of RA requires two enzymatic reactions: oxidation of retinol into retinaldehyde by alcohol dehydrogenases (ADHs) or retinol de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b64657fdb915e5955bd22341e6a83d1f
https://pubmed.ncbi.nlm.nih.gov/32665247
https://pubmed.ncbi.nlm.nih.gov/32665247
Publikováno v:
BioMed Research International
BioMed Research International, Vol 2018 (2018)
BioMed Research International, Vol 2018 (2018)
Purpose. Triple-negative breast cancer refers to breast cancer that does not express estrogen receptor (ER), progesterone receptor (PR), or human epidermal growth factor receptor 2 (Her2). This study aimed to identify the key pathways and genes and f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7d82add2a2ee2d7722d6d5203ab9148
https://doi.org/10.1155/2018/2760918
https://doi.org/10.1155/2018/2760918
Publikováno v:
Hearing Research. 364:1-11
Permanent hearing loss is often a result of damage to cochlear hair cells, which mammals are unable to regenerate. Non-mammalian vertebrates such as birds replace damaged hair cells and restore hearing function, but mechanisms controlling regeneratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2faa71349d473aa68591319838350464
https://doi.org/10.1016/j.heares.2018.04.008
https://doi.org/10.1016/j.heares.2018.04.008
Autor:
Su-Hua Sha, Atul K. Pandey, Saima Riazuddin, Hong-Wei Zheng, Chandrakala Puligilla, Khujista Haque
Publikováno v:
The Journal of Neuroscience. 36:1347-1361
Mechanosensory hair cells (HCs) residing in the inner ear are critical for hearing and balance. Precise coordination of proliferation, sensory specification, and differentiation during development is essential to ensure the correct patterning of HCs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e4dc7d0227048a10f21ae853a395c1
https://doi.org/10.1523/jneurosci.1853-15.2016
https://doi.org/10.1523/jneurosci.1853-15.2016
Autor:
Jinshu Xu, Jennifer Li, Bernd Fritzsch, Aarthi Ramakrishnan, Pin-Xian Xu, Li Shen, Huihui Jiang, Eddie Loh Y, Ting Zhang
Otic ectoderm gives rise to almost all cell types of the inner ear; however, the mechanisms that link transcription factors, chromatin, lineage commitment and differentiation capacity are largely unknown. Here we show that Brg1 chromatin-remodeling f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39e534811dcadd680f61eb7c815b9c2c