Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Inna Miroshnyk"'
Publikováno v:
Pharmaceutics, Vol 2, Iss 4, Pp 339-350 (2010)
Several biologically relevant phospholipids were assessed as potential carriers/additives for rapidly dissolving solid formulations of piroxicam (Biopharmaceutics Classification System Class II drug). On the basis of in vitro dissolution studies, dim
Externí odkaz:
https://doaj.org/article/fc297a5934e546f79ad08ab8d2324061
Autor:
Bert van Veen, Jorma Haarala, Inna Miroshnyk, Anna Shevchenko, Lars-Olof Pietilä, Sabiruddin Mirza, Jouko Yliruusi, Erkki Kolehmainen, Nonappa, Jukka Salmia, Kai Sinervo
Publikováno v:
Crystal Growth and Design. 13(11):4877-4884
The cocrystal formation potential of itraconazole, a potent antifungal drug, with C2–C10 aliphatic dicarboxylic acids has been investigated. Using two experimental screening techniques (solvent-assisted grinding and evaporation-based crystallizatio
Autor:
Hélder A. Santos, Bert van Veen, Kristýna Jelínková, Kaisa Syrjänen, Luis M. Bimbo, Jouko Yliruusi, Inna Miroshnyk, Anna Shevchenko, Jorma Haarala, Juha Kiesvaara
Publikováno v:
International Journal of Pharmaceutics. 436:403-409
Cocrystallization and salt formation have been shown to entail substantial promise in tailoring the physicochemical properties of drug compounds, in particular, their dissolution and hygroscopicity. In this work, we report on the preparation and comp
Autor:
Arto Tolvanen, Jouko Yliruusi, Saara Tiittanen, Karjalainen Arto Johannes, Mäkelä Mikko, David Din Belle, Veli Pekka Tanninen, Anna Shevchenko, Jorma Haarala, Inna Miroshnyk
Publikováno v:
Organic Process Research & Development. 15:666-672
The need for effective solid-form screening approaches, especially designed for the early discovery phases, is well recognized within the pharmaceutical industry. Here we report on the early polymorphism and solvatomorphism evaluation of a new drug c
Autor:
Inna Miroshnyk, Jouko Yliruusi, Sabiruddin Mirza, I. N. Urakova, Valery G. Makarov, Samuli Hirsjärvi, Raimo Hiltunen, Alexander N. Shikov, Olga N. Pozharitskaya, Jyrki Heinämäki
Publikováno v:
International Journal of Pharmaceutics. 377:148-152
Nanosizing is an advanced formulation approach to address the issues of poor aqueous solubility of active pharmaceutical ingredients. Here we present a procedure to prepare a nanoparticulate formulation with the objective to enhance dissolution kinet
Publikováno v:
Expert Opinion on Drug Delivery. 6:333-341
By maximizing our understanding of materials and the relative importance of interactions on all levels (i.e., molecular, particle, powder, product), we can improve the manufacture of drug dosage forms and thus meet target specifications for mechanica
Autor:
Osmo Antikainen, Jukka Rantanen, Jouko Yliruusi, Heikki Vuorela, Pia Vuorela, Sabiruddin Mirza, Inna Miroshnyk, Jyrki Heinämäki
Publikováno v:
Crystal Growth & Design. 8:3526-3531
Crystallization in the presence of pharmaceutically accepted excipients as additives was investigated as a tool for morphological crystal engineering of active pharmaceutical ingredients. Recrystallization of a model drug substance, erythromycin A di
Autor:
Niina Kivikero, Inna Miroshnyk, Jyrki Heinämäki, Jouko Yliruusi, M. Römer, Jukka Rantanen, Niklas Sandler
Publikováno v:
Journal of Pharmaceutical Sciences. 97:4020-4029
An in-line near infrared (NIR) spectrometer was employed to monitor phase transformations of erythromycin dihydrate during a miniaturized fluid bed drying process. The pellets, containing 50% (w/w) erythromycin dihydrate and 50% (w/w) microcrystallin
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 67:246-252
An at-line process analytical approach was applied to better understand process-induced transformations of erythromycin dihydrate during pellet manufacture (extrusion-spheronisation and drying process). The pellets contained 50% (w/w) erythromycin di
Autor:
Anna Cecilia Jørgensen, Jukka Rantanen, Inna Miroshnyk, Kirsi Jouppila, Simo Siiriä, Milja Karjalainen, Osmo Antikainen
Publikováno v:
Journal of Pharmaceutical Sciences. 95:906-916
A thorough understanding of solid state properties is of growing importance. It is often necessary to apply multiple techniques offering complementary information to fully understand the solid state behavior of a given compound and the relations betw