Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Inna M. Yasinska"'
Autor:
Maryam Abooali, Inna M. Yasinska, Stephanie Schlichtner, Sabrina Ruggiero, Steffen M. Berger, Dietmar Cholewa, Milan Milošević, Andreas Bartenstein, Elizaveta Fasler-Kan, Vadim V. Sumbayev
Publikováno v:
Translational Oncology, Vol 39, Iss , Pp 101805- (2024)
Malignant transformation of human cells is associated with their re-programming which results in uncontrolled proliferation and in the same time biochemical activation of immunosuppressive pathways which form cancer immune evasion machinery. However,
Externí odkaz:
https://doaj.org/article/8017fc6b56d84459acc2a497ce18cf29
Autor:
Stephanie Schlichtner, Inna M. Yasinska, Elena Klenova, Maryam Abooali, Gurprit S. Lall, Steffen M. Berger, Sabrina Ruggiero, Dietmar Cholewa, Milan Milošević, Bernhard F. Gibbs, Elizaveta Fasler-Kan, Vadim V. Sumbayev
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTMalignant tumors often escape anticancer immune surveillance by suppressing the cytotoxic functions of T lymphocytes. While many of these immune evasion networks include checkpoint proteins, small molecular weight compounds, such as the amino
Externí odkaz:
https://doaj.org/article/af8e958bbeec46739a4b45819fd24cbb
Autor:
Stephanie Schlichtner, Inna M. Yasinska, Sabrina Ruggiero, Steffen M. Berger, Nijas Aliu, Mateja Prunk, Janko Kos, N. Helge Meyer, Bernhard F. Gibbs, Elizaveta Fasler-Kan, Vadim V. Sumbayev
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Immune checkpoint proteins play crucial roles in human embryonic development but are also used by cancer cells to escape immune surveillance. These proteins and biochemical pathways associated with them form a complex machinery capable of blocking th
Externí odkaz:
https://doaj.org/article/df9cbb22cd0c4b25850127b6e31a3396
Autor:
Anette Teo Hansen Selnø, Stephanie Schlichtner, Inna M. Yasinska, Svetlana S. Sakhnevych, Walter Fiedler, Jasmin Wellbrock, Steffen M. Berger, Elena Klenova, Bernhard F. Gibbs, Elizaveta Fasler-Kan, Vadim V. Sumbayev
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
High mobility group box 1 (HMGB1) is a non-histone protein which is predominantly localised in the cell nucleus. However, stressed, dying, injured or dead cells can release this protein into the extracellular matrix passively. In addition, HMGB1 rele
Externí odkaz:
https://doaj.org/article/c04a7804921742bfb246d9e415af1d0d
Autor:
Inna M. Yasinska, N. Helge Meyer, Stephanie Schlichtner, Rohanah Hussain, Giuliano Siligardi, Maxwell Casely-Hayford, Walter Fiedler, Jasmin Wellbrock, Cloe Desmet, Luigi Calzolai, Luca Varani, Steffen M. Berger, Ulrike Raap, Bernhard F. Gibbs, Elizaveta Fasler-Kan, Vadim V. Sumbayev
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Acute myeloid leukemia (AML), a blood/bone marrow cancer, is a severe and often fatal malignancy. AML cells are capable of impairing the anti-cancer activities of cytotoxic lymphoid cells. This includes the inactivation of natural killer (NK) cells a
Externí odkaz:
https://doaj.org/article/fde3b7a88f6a40a58578f302b9d89082
Autor:
Isabel Gonçalves Silva, Inna M. Yasinska, Svetlana S. Sakhnevych, Walter Fiedler, Jasmin Wellbrock, Marco Bardelli, Luca Varani, Rohanah Hussain, Giuliano Siligardi, Giacomo Ceccone, Steffen M. Berger, Yuri A. Ushkaryov, Bernhard F. Gibbs, Elizaveta Fasler-Kan, Vadim V. Sumbayev
Publikováno v:
EBioMedicine, Vol 22, Iss C, Pp 44-57 (2017)
Acute myeloid leukemia (AML) is a severe and often fatal systemic malignancy. Malignant cells are capable of escaping host immune surveillance by inactivating cytotoxic lymphoid cells. In this work we discovered a fundamental molecular pathway, which
Externí odkaz:
https://doaj.org/article/e004d7f74c5c43a19b8c11d1701ce852
Autor:
Inna M. Yasinska, Svetlana S. Sakhnevych, Ludmila Pavlova, Anette Teo Hansen Selnø, Ana Maria Teuscher Abeleira, Ouafa Benlaouer, Isabel Gonçalves Silva, Marianne Mosimann, Luca Varani, Marco Bardelli, Rohanah Hussain, Giuliano Siligardi, Dietmar Cholewa, Steffen M. Berger, Bernhard F. Gibbs, Yuri A. Ushkaryov, Elizaveta Fasler-Kan, Elena Klenova, Vadim V. Sumbayev
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Human cancer cells operate a variety of effective molecular and signaling mechanisms which allow them to escape host immune surveillance and thus progress the disease. We have recently reported that the immune receptor Tim-3 and its natural ligand ga
Externí odkaz:
https://doaj.org/article/83b5108e523d4c67ad0de9fa49513b57
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
The Tim-3-galectin-9 secretory pathway is known to protect various types of cancer cells against host immune surveillance. We found that pharmacologically induced mitochondrial dysfunction leads to a reduced galectin-9 expression/exocytosis in human
Externí odkaz:
https://doaj.org/article/04bf3f042a8c4aa5aeb752fb467d9380
Autor:
Inna M. Yasinska, Luigi Calzolai, Ulrike Raap, Rohanah Hussain, Giuliano Siligardi, Vadim V. Sumbayev, Bernhard F. Gibbs
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Calcineurin inhibitors potentially prevent pro-allergic mediator release from basophils and mast cells but are rarely used systemically due to ubiquitous expressions of target signaling proteins. However, specific targeting of allergic effector cells
Externí odkaz:
https://doaj.org/article/3b65a95480b44f13895dedb94fdc3556
Autor:
Inna M. Yasinska, Isabel Gonçalves Silva, Svetlana S. Sakhnevych, Laura Ruegg, Rohanah Hussain, Giuliano Siligardi, Walter Fiedler, Jasmin Wellbrock, Marco Bardelli, Luca Varani, Ulrike Raap, Steffen Berger, Bernhard F. Gibbs, Elizaveta Fasler-Kan, Vadim V. Sumbayev
Publikováno v:
OncoImmunology, Vol 7, Iss 6 (2018)
High mobility group box 1 (HMGB1) is a non-histone protein localised in the cell nucleus, where it interacts with DNA and promotes nuclear transcription events. HMGB1 levels are elevated during acute myeloid leukaemia (AML) progression followed by pa
Externí odkaz:
https://doaj.org/article/f1559d5f566f4db29e11b14c3b81d118