Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Inna Krieger"'
Autor:
Jared S. Mackenzie, Dirk A. Lamprecht, Rukaya Asmal, John H. Adamson, Khushboo Borah, Dany J. V. Beste, Bei Shi Lee, Kevin Pethe, Simon Rousseau, Inna Krieger, James C. Sacchettini, Joel N. Glasgow, Adrie J. C. Steyn
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Bedaquiline (BDQ) is a known tuberculosis treatment, but the precise mechanism of cell death is unclear. Here, the authors explore the metabolic profiles of M. tuberculosis upon BDQ treatment and find reliance on glycolysis and synergistic cell death
Externí odkaz:
https://doaj.org/article/d680f868a7c742a69cdc3f6e9206d15b
Autor:
Danish Khan, Dongju Lee, Gulcin Gulten, Anup Aggarwal, Joshua Wofford, Inna Krieger, Ashutosh Tripathi, John W Patrick, Debra M Eckert, Arthur Laganowsky, James Sacchettini, Paul Lindahl, Vytas A Bankaitis
Publikováno v:
eLife, Vol 9 (2020)
Yeast Sfh5 is an unusual member of the Sec14-like phosphatidylinositol transfer protein (PITP) family. Whereas PITPs are defined by their abilities to transfer phosphatidylinositol between membranes in vitro, and to stimulate phosphoinositide signali
Externí odkaz:
https://doaj.org/article/33c5c7c3d2734eef83d198b262875ae8
Autor:
Scott A. Cameron, Lawrence Harris, Arthur Laganowsky, Zahra Moghadamchargari, Dan Torres, James C. Sacchettini, Inna Krieger, Thomas D. Meek, Drake M. Mellott
Publikováno v:
Journal of the American Chemical Society. 143:17666-17676
The isocitrate lyase paralogs of Mycobacterium tuberculosis (ICL1 and 2) are essential for mycobacterial persistence and constitute targets for the development of antituberculosis agents. We report that (2R,3S)-2-hydroxy-3-(nitromethyl)succinic acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c351d3ec7a29a2edb7258f6679913f0a
https://doi.org/10.1021/jacs.1c07970
https://doi.org/10.1021/jacs.1c07970
Autor:
Thomas D. Meek, Drake M. Mellott, Truc Viet Pham, Inna Krieger, Zahra Moghadamchargari, Kevin Chen, James C. Sacchettini, Arthur Laganowsky
Publikováno v:
ACS Chemical Biology. 16:463-470
The isocitrate lyases (ICL1/2) are essential enzymes of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis. At present, no ICL1/2 inhibitors have progressed to clinical evaluation, despite extensive drug discovery efforts. Herein,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5dfbb8c22455b348ac4f277806bb4fa3
https://doi.org/10.1021/acschembio.0c00740
https://doi.org/10.1021/acschembio.0c00740
Autor:
James C. Sacchettini, Jeewoo Lee, Jihyae Ann, Tatyana I. Igumenova, Sachin Katti, Inna Krieger
Diacylglycerol (DAG) is a versatile lipid whose 1,2-sn-stereoisomer serves both as second messenger in signal transduction pathways that control vital cellular processes, and as metabolic precursor for downstream signaling lipids such as phosphatidic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0e9c3e0a737d536972b19baffdcb8a8
https://doi.org/10.1101/2021.09.03.458901
https://doi.org/10.1101/2021.09.03.458901
Autor:
Truc Viet, Pham, Drake M, Mellott, Zahra, Moghadamchargari, Kevin, Chen, Inna, Krieger, Arthur, Laganowsky, James C, Sacchettini, Thomas D, Meek
Publikováno v:
ACS chemical biology. 16(3)
The isocitrate lyases (ICL1/2) are essential enzymes of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::caf5afb7680be2a903e3c4684b37e7da
https://pubmed.ncbi.nlm.nih.gov/33688722
https://pubmed.ncbi.nlm.nih.gov/33688722
Autor:
Pierce Jamieson, Inna Krieger, Benjamin A. Horwitz, James T. Taylor, Frankie K. Crutcher, Charles M. Kenerley, Michael V. Kolomiets
The filamentous fungus, Trichoderma virens, is a well-known mycoparasitic plant symbiont, valued for its biocontrol capabilities. T. virens initiates a symbiotic relationship with a plant host through the colonization of its roots. To achieve coloniz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19d003e6b8694a73148791004f6007fa
https://doi.org/10.1101/2021.01.07.425738
https://doi.org/10.1101/2021.01.07.425738
Autor:
Adrie J. C. Steyn, Joel N. Glasgow, Dirk A. Lamprecht, Simon Rousseau, Khushboo Borah, John H. Adamson, Rukaya Asmal, Dany J. V. Beste, James C. Sacchettini, Bei Shi Lee, Inna Krieger, Kevin Pethe, Jared S. Mackenzie
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The approval of bedaquiline (BDQ) for the treatment of tuberculosis has generated substantial interest in inhibiting energy metabolism as a therapeutic paradigm. However, it is not known precisely how BDQ triggers cell death in Mycobacterium tubercul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b25c4459dc9cdcf4168b39de95ebaec
https://doi.org/10.1038/s41467-020-19959-4
https://doi.org/10.1038/s41467-020-19959-4
Autor:
Debra M. Eckert, Danish Khan, Dongju Lee, Ashutosh Tripathi, Paul A. Lindahl, James C. Sacchettini, Vytas A. Bankaitis, Gulcin Gulten, Anup Aggarwal, John W. Patrick, Inna Krieger, Arthur Laganowsky, Joshua D. Wofford
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
Yeast Sfh5 is an unusual member of the Sec14-like phosphatidylinositol transfer protein (PITP) family. Whereas PITPs are defined by their abilities to transfer phosphatidylinositol between membranes in vitro, and to stimulate phosphoinositide signali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be619dc9ba0a9d9eb90a5565b125f393
https://doi.org/10.7554/elife.57081
https://doi.org/10.7554/elife.57081
Autor:
Vytas A. Bankaitis, Inna Krieger, Ashutosh Tripathi, Paul A. Lindahl, Anup Aggarwal, Gulcin Gulten, Danish Khan, James C. Sacchettini, Dongju Lee, Joshua D. Wofford, John W. Patrick, Arthur Laganowsky, Debra M. Eckert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b68d2019a44d418ee46f205f914c1ab7
https://doi.org/10.7554/elife.57081.sa2
https://doi.org/10.7554/elife.57081.sa2