Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Inna Khodos"'
Autor:
Romel Somwar, Nicolle E. Hofmann, Bryan Smith, Igor Odintsov, Morana Vojnic, Irina Linkov, Ashley Tam, Inna Khodos, Marissa S. Mattar, Elisa de Stanchina, Daniel Flynn, Marc Ladanyi, Alexander Drilon, Ujwal Shinde, Monika A. Davare
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-13 (2020)
Romel Somwar et al. find that cancer-causing NTRK gene fusions resistant to one form of inhibitor therapy can be resistant to other inhibitor types. Using molecular simulations, they show that some NTRK1 mutations resistant to the type I inhibitor la
Externí odkaz:
https://doaj.org/article/dc4dd666029c45298c0ddd64355c90c2
Autor:
Roger S. Smith, Igor Odintsov, Zebing Liu, Allan Jo-Weng Lui, Takuo Hayashi, Morana Vojnic, Yoshiyuki Suehara, Lukas Delasos, Marissa S. Mattar, Julija Hmeljak, Hillary A. Ramirez, Melissa Shaw, Gabrielle Bui, Alifiani B. Hartono, Eric Gladstone, Siddharth Kunte, Heather Magnan, Inna Khodos, Elisa De Stanchina, Michael P. La Quaglia, Jinjuan Yao, Marick Laé, Sean B. Lee, Lee Spraggon, Christine A. Pratilas, Marc Ladanyi, Romel Somwar
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 1 (2022)
Desmoplastic small round cell tumor (DSRCT) is characterized by the t(11;22)(p13;q12) translocation, which fuses the transcriptional regulatory domain of EWSR1 with the DNA-binding domain of WT1, resulting in the oncogenic EWSR1-WT1 fusion protein. T
Externí odkaz:
https://doaj.org/article/7b83f47a6c8e4d5eb829d9ab77a3d402
Autor:
Takuo Hayashi, Igor Odintsov, Roger S. Smith, Kota Ishizawa, Allan J. W. Liu, Lukas Delasos, Christopher Kurzatkowski, Huichun Tai, Eric Gladstone, Morana Vojnic, Shinji Kohsaka, Ken Suzawa, Zebing Liu, Siddharth Kunte, Marissa S. Mattar, Inna Khodos, Monika A. Davare, Alexander Drilon, Emily Cheng, Elisa de Stanchina, Marc Ladanyi, Romel Somwar
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 2 (2021)
Multi-kinase RET inhibitors, such as cabozantinib and RXDX-105, are active in lung cancer patients with RET fusions; however, the overall response rates to these two drugs are unsatisfactory compared to other targeted therapy paradigms. Moreover, the
Externí odkaz:
https://doaj.org/article/2e7e848718f248f5b1b70bad579df39d
Autor:
Michael Green, Dmitriy Zamarin, Katherine Panageas, Taha Merghoub, Weiping Zou, Cailian Liu, Jedd Wolchok, Matthew Hellmann, Joseph Chan, Hongyu Shi, Hira Rizvi, Jessica Waninger, Aditi Gupta, Nicholas Ceglia, Viola Allaj, Giulia Zago, Nisarg Shah, Sai Sharma, Marissa Mattar, Yonina Bykov, Corrin Wohlhieter, Fathema Uddin, Inna Khodos, Angel Qin, Vinod Balachandran, Sohrab Shah, Andrew McPherson, Jason Lewis, Justin Perry, Elisa de Stanchina, Triparna Sen, John Poirier, Charles Rudin
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/40d967b30569450689026463a728aa99
Autor:
Danilo Fiore, Luca Vincenzo Cappelli, Paul Zumbo, Jude M. Phillips, Zhaoqi Liu, Shuhua Cheng, Liron Yoffe, Paola Ghione, Federica Di Maggio, Ahmet Dogan, Inna Khodos, Elisa de Stanchina, Joseph Casano, Clarisse Kayembe, Wayne Tam, Doron Betel, Robin Foa’, Leandro Cerchietti, Raul Rabadan, Steven Horwitz, David M. Weinstock, Giorgio Inghirami
Publikováno v:
Cancers, Vol 12, Iss 6, p 1603 (2020)
Breast implant-associated lymphoma (BIA-ALCL) has recently been recognized as an independent peripheral T-cell lymphoma (PTCL) entity. In this study, we generated the first BIA-ALCL patient-derived tumor xenograft (PDTX) model (IL89) and a matching c
Externí odkaz:
https://doaj.org/article/6958d3085d5c47fdba82781ea47c3692
Autor:
Romel Somwar, Alexander Drilon, Marc Ladanyi, Eileen M. O'Reilly, Elisa de Stanchina, Ernesto Wasserman, Jeroen J. Lammerts van Bueren, Ron C.J. Schackmann, Cecile A.W. Geuijen, Marie N. O'Connor, Jim Ford, Jean Torrisi, Thrusha Chauhan, Sara H. Shameem, Morana Vojnic, Allan J.W. Lui, Marissa S. Mattar, Whitney J. Sisso, Inna Khodos, Madelyn Espinosa-Cotton, Igor Odintsov, Alison M. Schram
Supplementary Figure from Zenocutuzumab, a HER2xHER3 Bispecific Antibody, Is Effective Therapy for Tumors Driven by NRG1 Gene Rearrangements
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::957edba211dae8e33116bb0bbf5e53e7
https://doi.org/10.1158/2159-8290.22541186.v1
https://doi.org/10.1158/2159-8290.22541186.v1
Autor:
Romel Somwar, Alexander Drilon, Marc Ladanyi, Eileen M. O'Reilly, Elisa de Stanchina, Ernesto Wasserman, Jeroen J. Lammerts van Bueren, Ron C.J. Schackmann, Cecile A.W. Geuijen, Marie N. O'Connor, Jim Ford, Jean Torrisi, Thrusha Chauhan, Sara H. Shameem, Morana Vojnic, Allan J.W. Lui, Marissa S. Mattar, Whitney J. Sisso, Inna Khodos, Madelyn Espinosa-Cotton, Igor Odintsov, Alison M. Schram
NRG1 rearrangements are recurrent oncogenic drivers in solid tumors. NRG1 binds to HER3, leading to heterodimerization with other HER/ERBB kinases, increased downstream signaling, and tumorigenesis. Targeting ERBBs, therefore, represents a therapeuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29ad90ec0c5517efbc60698dfdb31aea
https://doi.org/10.1158/2159-8290.c.6549563.v1
https://doi.org/10.1158/2159-8290.c.6549563.v1
Autor:
Maurizio Scaltriti, Charles M. Rudin, Neal Rosen, Elisa de Stanchina, Gary A. Ulaner, Junji Tsurutani, Ronglai Shen, John T. Poirier, Mark G. Kris, Maria E. Arcila, Pedram Razavi, Jorge S. Reis-Filho, Vicky Makker, Alan L. Ho, Darren J. Buonocore, Jason S. Lewis, David M. Hyman, Fabiola Cecchi, Anuja Bhalkikar, Wei-Li Liao, Sheeno Thyparambil, Helena A. Yu, David R. Jones, James M. Isbell, Michael Offin, Tony Ng, Paul R. Barber, Michael F. Berger, David B. Solit, Nancy U. Lin, Rachel A. Freedman, Irmina Diala, Alshad S. Lalani, Clare J. Wilhem, Gregory Weitsman, Besnik Qeriqi, Megan Little, Inna Khodos, Marissa Mattar, Chongrui Xu, Mackenzie L. Myers, Hai-Yan Tu, Sophie Shifman, Yanyan Cai, Laura Baldino, Emiliano Cocco, Sandra Misale, Flavia Michelini, Bob T. Li
Supplementary Fig 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca68ba963c9d89ca2601a9b13e440c0
https://doi.org/10.1158/2159-8290.22535620
https://doi.org/10.1158/2159-8290.22535620
Autor:
Maurizio Scaltriti, Charles M. Rudin, Neal Rosen, Elisa de Stanchina, Gary A. Ulaner, Junji Tsurutani, Ronglai Shen, John T. Poirier, Mark G. Kris, Maria E. Arcila, Pedram Razavi, Jorge S. Reis-Filho, Vicky Makker, Alan L. Ho, Darren J. Buonocore, Jason S. Lewis, David M. Hyman, Fabiola Cecchi, Anuja Bhalkikar, Wei-Li Liao, Sheeno Thyparambil, Helena A. Yu, David R. Jones, James M. Isbell, Michael Offin, Tony Ng, Paul R. Barber, Michael F. Berger, David B. Solit, Nancy U. Lin, Rachel A. Freedman, Irmina Diala, Alshad S. Lalani, Clare J. Wilhem, Gregory Weitsman, Besnik Qeriqi, Megan Little, Inna Khodos, Marissa Mattar, Chongrui Xu, Mackenzie L. Myers, Hai-Yan Tu, Sophie Shifman, Yanyan Cai, Laura Baldino, Emiliano Cocco, Sandra Misale, Flavia Michelini, Bob T. Li
Supplementary Fig 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fc8a692cd14f0c9c16a0213065f8c31
https://doi.org/10.1158/2159-8290.22535626
https://doi.org/10.1158/2159-8290.22535626
Autor:
Monika A. Davare, Romel Somwar, Marc Ladanyi, Gregory J. Riely, Alexander Drilon, Inna Khodos, Elisa de Stanchina, Marissa S. Mattar, Evan Siau, Adam J. Schoenfeld, Igor Odintsov, Sudarshan R. Iyer
Supplementary Figure from MYC Promotes Tyrosine Kinase Inhibitor Resistance in ROS1-Fusion-Positive Lung Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14cd1cbc3ae3a642d3da55c2f8fffbf3
https://doi.org/10.1158/1541-7786.22527461.v1
https://doi.org/10.1158/1541-7786.22527461.v1