Zobrazeno 1 - 10 of 24 pro vyhledávání: '"Inna Gorshkova"'
1
Charge Density Influences C1 Domain Ligand Affinity and Membrane Interactions
Autor: Noemi Kedei, Tamás Géczy, Nancy E. Lewin, Julia S. Selezneva, Peter M. Blumberg, Colin S. Hill, Inna Gorshkova, Christopher J. Valle, Wonhee Woo, Jessica S. Kelsey
Publikováno v: ChemBioChem. 15:1131-1144
The C1 domain, which represents the recognition motif on protein kinase C for the lipophilic second messenger diacylglycerol and its ultrapotent analogues, the phorbol esters, has emerged as a promising therapeutic target for cancer and other indicat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df919ec747e73d8fbeddf68e291e49a3
https://doi.org/10.1002/cbic.201400041
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2
Expression, surface immobilization, and characterization of functional recombinant cannabinoid receptor CB2
Autor: Alexei Yeliseev, Inna Gorshkova, Klaus Gawrisch, Silvia Locatelli-Hoops
Publikováno v: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1834:2045-2056
Human peripheral cannabinoid receptor CB2, a G protein-coupled receptor (GPCR) involved in regulation of immune response has become an important target for pharmaceutical drug development. Structural and functional studies on CB2 may benefit from imm
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e8b13cbcefa7e5f5e536f1e4dbe7fb0
https://doi.org/10.1016/j.bbapap.2013.06.003
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3
Novel Chimpanzee/Human Monoclonal Antibodies That Neutralize Anthrax Lethal Factor, and Evidence for Possible Synergy with Anti-Protective Antigen Antibody
Autor: Inna Gorshkova, Mahtab Moayeri, Suzanne U. Emerson, Robert H. Purcell, Zhaochun Chen, Stephen H. Leppla, Devorah Crown, Peter Schuck
Publikováno v: Infection and Immunity. 77:3902-3908
Three chimpanzee Fabs reactive with lethal factor (LF) of anthrax toxin were isolated and converted into complete monoclonal antibodies (MAbs) with human γ1 heavy-chain constant regions. In a macrophage toxicity assay, two of the MAbs, LF10E and LF1
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6b3fe442fb30f9e51d2534dd147cc3b
https://doi.org/10.1128/iai.00200-09
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4
Two Interferons Alpha Influence Each Other during Their Interaction with the Extracellular Domain of Human Type Interferon Receptor Subunit 2
Autor: Patrick O. Brown, Kathryn C. Zoon, Inna Gorshkova, Peter Schuck, Peter Kontsek, Hana Schmeisser
Publikováno v: Biochemistry. 46:14638-14649
The interaction between two human interferons alpha (IFN-alphas) and the extracellular (EC) domain of human type I IFN receptor subunit 2 (IFNAR2) was analyzed. Previous experiments using Daudi cells showed that IFN-alpha21b and some IFN-alpha hybrid
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d34c7b1b20fe839a847bcf66ecb6aca3
https://doi.org/10.1021/bi7012036
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6
Eukaryotic RNases H1 act processively by interactions through the duplex RNA-binding domain
Autor: Inna Gorshkova, Susana M. Cerritelli, Sergei Gaidamakov, Robert J. Crouch, Peter Schuck, Peter J. Steinbach, Hirofumi Yamada
Publikováno v: Nucleic Acids Research
Ribonucleases H have mostly been implicated in eliminating short RNA primers used for initiation of lagging strand DNA synthesis. Escherichia coli RNase HI cleaves these RNA–DNA hybrids in a distributive manner. We report here that eukaryotic RNase
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb157ca22762d36f4d7a598dd5542bbd
http://europepmc.org/articles/PMC1079969
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8
Humanized docking system for assembly of targeting drug delivery complexes
Autor: Timur I. Gaynutdinov, Joseph M. Backer, Mohamed Arab, Inna Gorshkova, Marina V. Backer, Tao Hu, Robert J. Crouch, Renee Aloise, Kristen Przekop
Publikováno v: Journal of Controlled Release. 89:499-511
Targeted drug delivery requires ‘loading’ drugs onto targeting proteins. Traditional technologies for loading drugs rely on chemical conjugation of drugs or drug carriers to targeting proteins. An alternative approach might rely on assembly of ta
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cde9d14c4b97b3e17d2f055697f052d2
https://doi.org/10.1016/s0168-3659(03)00150-0
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9
Tyrosine sulfation in the second variable loop (V2) of HIV-1 gp120 stabilizes V2–V3 interaction and modulates neutralization sensitivity
Autor: Yin Lin, Patrick O. Brown, James Arthos, Paolo Lusso, Peng Zhang, Raffaello Cimbro, Donald Van Ryk, Thomas Gallant, Darrell E. Hurt, Inna Gorshkova, Christina Guzzo, Huiyi Miao, Michael A. Dolan
Elicitation of broadly neutralizing antibodies is essential for the development of a protective vaccine against HIV-1. However, the native HIV-1 envelope adopts a protected conformation that conceals highly conserved sites of vulnerability from antib
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e22104def95fd06d4a1bbe76cf20d5c9
https://europepmc.org/articles/PMC3939864/
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10
Surface plasmon resonance applied to G protein-coupled receptors
Autor: Inna Gorshkova, Alexei Yeliseev, Silvia Locatelli-Hoops, Klaus Gawrisch
Publikováno v: Biomedical spectroscopy and imaging. 2(3)
G protein-coupled receptors (GPCR) are integral membrane proteins that transmit signals from external stimuli to the cell interior via activation of GTP-binding proteins (G proteins) thereby mediating key sensorial, hormonal, metabolic, immunological
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f0de1e3b0b47006c9c128342cea701d
https://pubmed.ncbi.nlm.nih.gov/24466506
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