Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Inna Goreshnik"'
Autor:
Buwei Huang, Brian Coventry, Marta T. Borowska, Dimitrios C. Arhontoulis, Marc Exposit, Mohamad Abedi, Kevin M. Jude, Samer F. Halabiya, Aza Allen, Cami Cordray, Inna Goreshnik, Maggie Ahlrichs, Sidney Chan, Hillary Tunggal, Michelle DeWitt, Nathaniel Hyams, Lauren Carter, Lance Stewart, Deborah H. Fuller, Ying Mei, K. Christopher Garcia, David Baker
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Cytokine release syndrome (CRS), commonly known as cytokine storm, is an acute systemic inflammatory response that is a significant global health threat. Interleukin-6 (IL-6) and interleukin-1 (IL-1) are key pro-inflammatory cytokines involv
Externí odkaz:
https://doaj.org/article/5f93a3f590e5444ea2f8d8872b6aedb3
Autor:
Nathaniel R. Bennett, Brian Coventry, Inna Goreshnik, Buwei Huang, Aza Allen, Dionne Vafeados, Ying Po Peng, Justas Dauparas, Minkyung Baek, Lance Stewart, Frank DiMaio, Steven De Munck, Savvas N. Savvides, David Baker
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)
Abstract Recently it has become possible to de novo design high affinity protein binding proteins from target structural information alone. There is, however, considerable room for improvement as the overall design success rate is low. Here, we explo
Externí odkaz:
https://doaj.org/article/279adbbdbddf4e41bbd9f4a899f986cf
Autor:
Kejia Wu, Hua Bai, Ya-Ting Chang, Rachel Redler, Kerrie E. McNally, William Sheffler, T. J. Brunette, Derrick R. Hicks, Tomos E. Morgan, Tim J. Stevens, Adam Broerman, Inna Goreshnik, Michelle DeWitt, Cameron M. Chow, Yihang Shen, Lance Stewart, Emmanuel Derivery, Daniel Adriano Silva, Gira Bhabha, Damian C. Ekiert, David Baker
Publikováno v:
Nature. 616:581-589
General approaches for designing sequence-specific peptide-binding proteins would have wide utility in proteomics and synthetic biology. However, designing peptide-binding proteins is challenging, as most peptides do not have defined structures in is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38bfb531fd20eb4be08615c8e33d81d2
https://doi.org/10.1038/s41586-023-05909-9
https://doi.org/10.1038/s41586-023-05909-9
Autor:
Longxing Cao, Brian Coventry, Inna Goreshnik, Buwei Huang, William Sheffler, Joon Sung Park, Kevin M. Jude, Iva Marković, Rameshwar U. Kadam, Koen H. G. Verschueren, Kenneth Verstraete, Scott Thomas Russell Walsh, Nathaniel Bennett, Ashish Phal, Aerin Yang, Lisa Kozodoy, Michelle DeWitt, Lora Picton, Lauren Miller, Eva-Maria Strauch, Nicholas D. DeBouver, Allison Pires, Asim K. Bera, Samer Halabiya, Bradley Hammerson, Wei Yang, Steffen Bernard, Lance Stewart, Ian A. Wilson, Hannele Ruohola-Baker, Joseph Schlessinger, Sangwon Lee, Savvas N. Savvides, K. Christopher Garcia, David Baker
Publikováno v:
NATURE
The design of proteins that bind to a specific site on the surface of a target protein using no information other than the three-dimensional structure of the target remains a challenge1–5. Here we describe a general solution to this problem that st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab523f5e18cc78b7c277b545d214fda8
https://doi.org/10.1038/s41586-022-04654-9
https://doi.org/10.1038/s41586-022-04654-9
Autor:
Kejia Wu, Hua Bai, Ya-Ting Chang, Rachel Redler, Kerrie E. McNally, William Sheffler, TJ Brunette, Derrick R. Hicks, Tomos E Morgan, Tim J Stevens, Adam Broerman, Inna Goreshnik, Michelle DeWitt, Cameron M. Chow, Yihang Shen, Lance Stewart, Emmanuel Derivery, Daniel Adriano Silva, Gira Bhabha, Damian Ekiert, David Baker
General approaches for designing sequence-specific peptide binding proteins would have wide utility in proteomics and synthetic biology. Although considerable progress has been made in designing proteins which bind to other proteins, the general pept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a7fff23e15bdae13920e1136bfa6c20
https://doi.org/10.1101/2022.11.14.514089
https://doi.org/10.1101/2022.11.14.514089
Autor:
Nathaniel Bennett, Brian Coventry, Inna Goreshnik, Buwei Huang, Aza Allen, Dionne Vafeados, Ying Po Peng, Justas Dauparas, Minkyung Baek, Lance Stewart, Frank DiMaio, Steven De Munck, Savvas N. Savvides, David Baker
We explore the improvement of energy-based protein binder design using deep learning. We find that using AlphaFold2 or RoseTTAFold to assess the probability that a designed sequence adopts the designed monomer structure, and the probability that this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67ef1ed5128106ab6a3f74277fb56334
https://doi.org/10.1101/2022.06.15.495993
https://doi.org/10.1101/2022.06.15.495993
Publikováno v:
Mol Syst Des Eng
Genetic selection combined with next-generation sequencing enables the simultaneous interrogation of the functionality and stability of large numbers of naturally occurring, engineered, or computationally designed protein variants in parallel. We dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::659a8e85a90326f98781c94f1b707247
https://pubmed.ncbi.nlm.nih.gov/35265342
https://pubmed.ncbi.nlm.nih.gov/35265342
Autor:
David Veesler, David Baker, Lauren Miller, Lexi Walls, James Brett Case, Michael S. Diamond, Lisa Kozodoy, Brian Coventry, Lance Stewart, Longxing Cao, Rita E. Chen, Young-Jun Park, Lauren Carter, Inna Goreshnik
Publikováno v:
Science
bioRxiv
Science (New York, N.y.)
bioRxiv
Science (New York, N.y.)
Miniproteins against SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is decorated with spikes, and viral entry into cells is initiated when these spikes bind to the host angiotensin-converting enzyme 2 (ACE2) receptor. Many mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7c7a152687503fd42604ca29dd3f826
https://doi.org/10.1126/science.abd9909
https://doi.org/10.1126/science.abd9909
Autor:
Frank DiMaio, Asim K. Bera, Christoffer Norn, Cameron M. Chow, Lauren Carter, Benjamin Basanta, David Baker, Inna Goreshnik, Matthew J. Bick
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Reengineering naturally occurring proteins to have new functions has had considerable impact on industrial and biomedical applications, but is limited by the finite number of known proteins. A promise of de novo protein design is to gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8030e9a2e291c5d9a6ba29029012191c
http://europepmc.org/articles/PMC7486743
http://europepmc.org/articles/PMC7486743
Autor:
Andrew C. Hunt, James Brett Case, Young-Jun Park, Longxing Cao, Kejia Wu, Alexandra C. Walls, Zhuoming Liu, John E. Bowen, Hsien-Wei Yeh, Shally Saini, Louisa Helms, Yan Ting Zhao, Tien-Ying Hsiang, Tyler N. Starr, Inna Goreshnik, Lisa Kozodoy, Lauren Carter, Rashmi Ravichandran, Lydia B. Green, Wadim L. Matochko, Christy A. Thomson, Bastian Vögeli, Antje Krüger, Laura A. VanBlargan, Rita E. Chen, Baoling Ying, Adam L. Bailey, Natasha M. Kafai, Scott E. Boyken, Ajasja Ljubetič, Natasha Edman, George Ueda, Cameron M. Chow, Max Johnson, Amin Addetia, Mary-Jane Navarro, Nuttada Panpradist, Michael Gale, Benjamin S. Freedman, Jesse D. Bloom, Hannele Ruohola-Baker, Sean P. J. Whelan, Lance Stewart, Michael S. Diamond, David Veesler, Michael C. Jewett, David Baker
Publikováno v:
SCIENCE TRANSLATIONAL MEDICINE
Science translational medicine, vol 14, iss 646
Science translational medicine, vol 14, iss 646
New variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue to arise and prolong the coronavirus disease 2019 (COVID-19) pandemic. Here, we used a cell-free expression workflow to rapidly screen and optimize constructs conta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e9758b09294bd495cfb2f91fd5c62ec