Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Inna Golberg"'
Autor:
William J. McCarty, Osman Berk Usta, Abhinav Bhushan, Rohit Jindal, Shyam Sundhar Bale, Martin L. Yarmush, Ljupcho Prodanov, Inna Golberg, Manjunath Hegde
Publikováno v:
Biotechnology and Bioengineering. 113:241-246
The development of long-term human organotypic liver-on-a-chip models for successful prediction of toxic response is one of the most important and urgent goals of the NIH/DARPA's initiative to replicate and replace chronic and acute drug testing in a
Autor:
William J. McCarty, Inna Golberg, Martin L. Yarmush, Manjunath Hegde, Abhinav Bhushan, Rohit Jindal, Shyam Sundhar Bale, Martha Luitje, Osman Berk Usta
Publikováno v:
Tissue Engineering Part C: Methods. 21:413-422
Hepatocytes and their in vitro models are essential tools for preclinical screening studies for drugs that affect the liver. Most of the current models primarily focus on hepatocytes alone and lack the contribution of non-parenchymal cells (NPCs), wh
Autor:
William J. McCarty, Martin L. Yarmush, Abhinav Bhushan, Osman Berk Usta, Inna Golberg, Manjunath Hegde, Rohit Jindal, Shyam Sundhar Bale
Publikováno v:
TECHNOLOGY. :1-26
The liver performs many key functions, the most prominent of which is serving as the metabolic hub of the body. For this reason, the liver is the focal point of many investigations aimed at understanding an organism's toxicological response to endoge
Autor:
William J. McCarty, Abhinav Bhushan, Tong Ying Shun, Ahmet Bakan, Rohit Jindal, Shyam Sundhar Bale, Richard DeBiasio, D. Lansing Taylor, Lawrence Vernetti, Albert Gough, Berk Osman Usta, Inna Golberg, Martin L. Yarmush, Nina Senutovitch, Manjunath Hegde
Publikováno v:
Experimental Biology and Medicine. 239:1180-1191
The liver is a heterogeneous organ with many vital functions, including metabolism of pharmaceutical drugs and is highly susceptible to injury from these substances. The etiology of drug-induced liver disease is still debated although generally regar
Autor:
Inna Golberg, William J. McCarty, Rohit Jindal, Shyam Sundhar Bale, O. Berk Usta, Martin L. Yarmush, Abhinav Bhushan, Manjunath Hegde
Publikováno v:
Lab Chip. 14:2033-2039
The creation of stable flow cultures of hepatocytes is highly desirable for the development of platforms for drug toxicity screening, bio-artificial liver support devices, and models for investigating liver physiology and pathophysiology. Given that
Autor:
Rohit Jindal, Shyam Sundhar Bale, William J. McCarty, Inna Golberg, Martin L. Yarmush, Ljupcho Prodanov, Osman Berk Usta, Gautham V. Sridharan
To evaluate drug and metabolite efficacy on a target organ, it is essential to include metabolic function of hepatocytes, and to evaluate metabolite influence on both hepatocytes and the target of interest. Herein, we have developed a two-chamber mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adff1a78a7711bf7624c9fd0bc809b6d
https://europepmc.org/articles/PMC4764261/
https://europepmc.org/articles/PMC4764261/
Autor:
Inna Golberg, Manjunath Hegde, William J. McCarty, O. Berk Usta, Martin L. Yarmush, Rohit Jindal, Shyam Sundhar Bale, Abhinav Bhushan, Martha Luitje
The creation of stable hepatocyte cultures using cell-matrix interactions has proven difficult in microdevices due to dimensional constraints limiting the utility of classic tissue culture techniques that involve the use of hydrogels such as the coll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::152e2cd58c2f0fc7fa95f6ce314a46a5
https://europepmc.org/articles/PMC4054686/
https://europepmc.org/articles/PMC4054686/
Autor:
Rohit Jindal, Shyam Sundhar Bale, William J. McCarty, Richard Biasio, O. Berk Usta, Albert Gough, Manjunath Hegde, Ahmet Bakan, Martin L. Yarmush, Abhinav Bhushan, D. Lansing Taylor, Inna Golberg, Tong Ying Shun, Lawrence Vernetti, Nina Senutovitch
Publikováno v:
Stem Cell Research & Therapy
Although the process of drug development requires efficacy and toxicity testing in animals prior to human testing, animal models have limited ability to accurately predict human responses to xenobiotics and other insults. Societal pressures are also