Rapid evolution of virulence and drug resistance in the emerging zoonotic pathogen Streptococcus suis.

Autor: Matthew T G Holden, Heidi Hauser, Mandy Sanders, Thi Hoa Ngo, Inna Cherevach, Ann Cronin, Ian Goodhead, Karen Mungall, Michael A Quail, Claire Price, Ester Rabbinowitsch, Sarah Sharp, Nicholas J Croucher, Tran Bich Chieu, Nguyen Thi Hoang Mai, To Song Diep, Nguyen Tran Chinh, Michael Kehoe, James A Leigh, Philip N Ward, Christopher G Dowson, Adrian M Whatmore, Neil Chanter, Pernille Iversen, Marcelo Gottschalk, Josh D Slater, Hilde E Smith, Brian G Spratt, Jianguo Xu, Changyun Ye, Stephen Bentley, Barclay G Barrell, Constance Schultsz, Duncan J Maskell, Julian Parkhill

Publikováno v: PLoS ONE, Vol 4, Iss 7, p e6072 (2009)

BACKGROUND:Streptococcus suis is a zoonotic pathogen that infects pigs and can occasionally cause serious infections in humans. S. suis infections occur sporadically in human Europe and North America, but a recent major outbreak has been described in

Externí odkaz: https://doaj.org/article/d0cf175f60c743c58c9ef9e4def64ac4

The genome of the simian and human malaria parasite Plasmodium knowlesi

Autor: Marie-Adèle Rajandream, Mandy Sanders, Mark Simmonds, Danielle Walker, S. Sanders, Tobias Mourier, Celine Carret, Al Ivens, Thomas M. Keane, Jaina Mistry, Martin Aslett, Sharon Moule, Douglas Ormond, Tobias Sargeant, Alan W. Thomas, Inna Cherevach, Brian White, Clemens H. M. Kocken, Mary R. Galinski, S. Balasubrammaniam, R. Squares, Arnab Pain, Neil Hall, Alan F. Cowman, Andrew Berry, Stacey A. Lapp, Scott Thurston, Michael A. Quail, Karsten M. Borgwardt, Tim Carver, Nicholas S. Peters, Irmtraud M. Meyer, Frances Smith, Tracey Chillingworth, Taane G. Clark, Eduard Zuiderwijk, Matthew Berriman, Adrian Tivey, Matthias Marti, Chris I. Newbold, C. M. R. Turner, D. Harper, Natasha Larke, Christoph S. Janssen, Bart Barrell, Heidi Hauser, Erica M. Pasini, Carol Churcher, Karen Brooks, Ulrike Böhme, Andrew P. Jackson, Karen Mungall, Robert D. Finn, David Harris

Publikováno v: Nature, 455

Plasmodium knowlesi is an intracellular malaria parasite whose natural vertebrate host is Macaca fascicularis (the ‘kra’ monkey); however, it is now increasingly recognized as a significant cause of human malaria, particularly in southeast Asia1,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::024c5eeb1be78d11c86df3f6b1611890
https://ora.ox.ac.uk/objects/uuid:d033391f-dc38-479c-9686-227efaed704c

The Systematic Functional Analysis of Plasmodium Protein Kinases Identifies Essential Regulators of Mosquito Transmission

Autor: Inna Cherevach, Alex Bateman, Rita Tewari, Oliver Billker, Ursula Straschil, Ulrike Böhme, Peng Gong, Arnab Pain

Publikováno v: Cell Host & Microbe

Summary Although eukaryotic protein kinases (ePKs) contribute to many cellular processes, only three Plasmodium falciparum ePKs have thus far been identified as essential for parasite asexual blood stage development. To identify pathways essential fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6e8b18d3dbf9d15d622130394edb2f4

The genome of a pathogenic rhodococcus: cooptive virulence underpinned by key gene acquisitions

Autor: M. Blanco, José A. Vázquez-Boland, Alain Ocampo, Michal Letek, Inna Cherevach, Tom C. Freeman, Jolyon Holdstock, Desmond P Leadon, John F. Prescott, Mandy Sanders, Tom Buckley, Ruth J. Fahey, Mariela Scortti, Michael A. Quail, Ursula Fogarty, Ana Valero-Rello, Jesús Navas, Héctor Rodríguez, Wim G. Meijer, Patricia González, Julian Parkhill, Stephen D. Bentley, Alexia Hapeshi, Iain MacArthur

Publikováno v: PLoS Genetics. 2010 Sep 30;6(9). pii: e1001145
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
PLoS Genetics
PLOS GENETICS
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
Letek, M, Gonzalez, P, MacArthur, I, Rodriguez, H, Freeman, T C, Valero Rello, A, Blanco, M, Buckley, T, Cherevach, I, Fahey, R, Hapeshi, A, Holdstock, J, Leadon, D, Navas, J, Ocampo, A, Quail, M A, Sanders, M, Scortti, M M, Prescott, J F, Fogarty, U, Meijer, W G, Parkhill, J, Bentley, S D & Vazquez-Boland, J A 2010, ' The Genome of a Pathogenic Rhodococcus: Cooptive Virulence Underpinned by Key Gene Acquisitions ', PLoS Genetics, vol. 6, no. 9, e1001145, pp.-. https://doi.org/10.1371/journal.pgen.1001145
PLoS Genetics, 2010, 6(9), e1001145
PLoS Genetics, Vol 6, Iss 9, p e1001145 (2010)

We report the genome of the facultative intracellular parasite Rhodococcus equi, the only animal pathogen within the biotechnologically important actinobacterial genus Rhodococcus. The 5.0-Mb R. equi 103S genome is significantly smaller than those of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac62492e5697cd5c6b4a9dcd77c0dd67
http://hdl.handle.net/10902/1536

Comparative genome analysis of Salmonella Enteritidis PT4 and Salmonella Gallinarum 287/91 provides insights into evolutionary and host adaptation pathways

Autor: Paul A. Barrow, Derek Pickard, Sharon Moule, Karen Brooks, Angela Lord, Michael Watson, Alex Bignell, Michael A. Quail, Mandy Sanders, Carol Churcher, Halina Norberczak, Debra J. Clayton, Tracey Chillingworth, Barbara Harris, Louise Clark, Karen Mungall, José A. Chabalgoity, Zahra Abdellah, Inna Cherevach, Kay Jagels, Susanne Davidson, Andy Barron, Daniel Windhorst, Abigail N. Layton, Doug Ormond, Sally Whitehead, Michael Jones, Duncan J. Maskell, John Woodward, Gordon Dougan, Claire Arrowsmith, Nicholas R. Thomson, Georgios S. Vernikos, Mark Roberts, Julian Parkhill, Mark P. Stevens, Robert A. Kingsley, Tom J. Humphrey

Publikováno v: Thomson, N R, Clayton, D J, Windhorst, D, Vernikos, G, Davidson, S, Churcher, C, Quail, M A, Stevens, M, Jones, M A, Watson, M, Barron, A, Layton, A, Pickard, D, Kingsley, R A, Bignell, A, Clark, L, Harris, B, Ormond, D, Abdellah, Z, Brooks, K, Cherevach, I, Chillingworth, T, Woodward, J, Norberczak, H, Lord, A, Arrowsmith, C, Jagels, K, Moule, S, Mungall, K, Sanders, M, Whitehead, S, Chabalgoity, J A, Maskell, D, Humphrey, T, Roberts, M, Barrow, P A, Dougan, G & Parkhill, J 2008, ' Comparative genome analysis of Salmonella Enteritidis PT4 and Salmonella Gallinarum 287/91 provides insights into evolutionary and host adaptation pathways ', Genome Research, vol. 18, no. 10, pp. 1624-1637 . https://doi.org/10.1101/gr.077404.108

We have determined the complete genome sequences of a host-promiscuous Salmonella enterica serovar Enteritidis PT4 isolate P125109 and a chicken-restricted Salmonella enterica serovar Gallinarum isolate 287/91. Genome comparisons between these and ot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::716b8ea466490e2e44ac0bb48df69bf8
https://hdl.handle.net/20.500.11820/f56db2da-1330-4fef-ab0e-b91aa7989879