CREB signaling activity correlates with differentiation and survival in medulloblastoma

Autor: Inna Armandari, Walderik W. Zomerman, Sabine L. A. Plasschaert, Marlinde J. Smit, Tosca. E. I. Martini, Eduardo S. de Camargo Magalhães, Shanna M. Hogeling, Geesina C. Rozema-Huizinga, Harm J. Lourens, Tiny G. J. Meeuwsen-de Boer, Frank J. G. Scherpen, Eveline S. J. M. de Bont, Sophia W. M. Bruggeman

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)

Abstract While there has been significant progress in the molecular characterization of the childhood brain cancer medulloblastoma, the tumor proteome remains less explored. However, it is important to obtain a complete understanding of medulloblasto

Externí odkaz: https://doaj.org/article/4b52aa87cc92410bae837f1ba12b32f3

Intratumoral steroidogenesis in castration-resistant prostate cancer: a target for therapy

Autor: Inna Armandari, Agus Rizal Hamid, Gerald Verhaegh, Jack Schalken

Publikováno v: Prostate International, Vol 2, Iss 3, Pp 105-113 (2014)

Development of castration-resistant prostate cancer (CRPC) in a low androgen environment, arising from androgen deprivation therapy (ADT), is a major problem in patients with advanced prostate cancer (PCa). Several mechanisms have been hypothesized t

Externí odkaz: https://doaj.org/article/b04129069fdd4684b78810c4583e95fe

CREB signaling activity correlates with differentiation and survival in medulloblastoma

Autor: Walderik W. Zomerman, Sophia W.M. Bruggeman, Eduardo Sabino de Camargo Magalhães, Harm Jan Lourens, Frank J. G. Scherpen, Eveline S. J. M. de Bont, Tosca. E. I. Martini, Marlinde J. Smit, Shanna M. Hogeling, Tiny G. J. Meeuwsen-de Boer, Sabine L. A. Plasschaert, Geesina C. Rozema-Huizinga, Inna Armandari

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports, 11(1):16077. Nature Publishing Group

While there has been significant progress in the molecular characterization of the childhood brain cancer medulloblastoma, the tumor proteome remains less explored. However, it is important to obtain a complete understanding of medulloblastoma protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd34b901125eb57feb5a6b2d298848a
https://doaj.org/article/4b52aa87cc92410bae837f1ba12b32f3

The H3.3K27M oncohistone affects replication stress outcome and provokes genomic instability in pediatric glioma

Autor: Jonas Seiler, Marin T Mondria, Irena Bockaj, Marcel A. T. M. van Vugt, Bjorn Bakker, Diana C.J. Spierings, Femke Ringnalda, Saskia L Meuleman, Mathilde J.C. Broekhuis, Ulrich Schüller, Floris Foijer, Hans Clevers, Colin Stok, Tosca. E. I. Martini, Eduardo Sabino de Camargo Magalhães, Hilda van den Bos, Yannick P Kok, Tiny G. J. Meeuwsen-de Boer, Inna Armandari, René Wardenaar, Petra L. Bakker, Sophia W.M. Bruggeman

Publikováno v: PLoS Genetics, Vol 17, Iss 11 (2021)
PLoS Genetics, 17(11). Public Library of Science
PLoS genetics, 17(11):1009868. PUBLIC LIBRARY SCIENCE
PLoS Genetics, Vol 17, Iss 11, p e1009868 (2021)
Bočkaj, I, Martini, T E I, de Camargo Magalhães, E S, Bakker, P L, Meeuwsen-de Boer, T G J, Armandari, I, Meuleman, S L, Mondria, M T, Stok, C, Kok, Y P, Bakker, B, Wardenaar, R, Seiler, J, Broekhuis, M J C, van den Bos, H, Spierings, D C J, Ringnalda, F C A, Clevers, H, Schüller, U, van Vugt, M A T M, Foijer, F & Bruggeman, S W M 2021, ' The H3.3K27M oncohistone affects replication stress outcome and provokes genomic instability in pediatric glioma ', PLoS Genetics, vol. 17, no. 11, e1009868, pp. e1009868 . https://doi.org/10.1371/journal.pgen.1009868
PLoS Genetics, 17(11):e1009868. Public Library of Science
PLoS Genetics

While comprehensive molecular profiling of histone H3.3 mutant pediatric high-grade glioma has revealed extensive dysregulation of the chromatin landscape, the exact mechanisms driving tumor formation remain poorly understood. Since H3.3 mutant gliom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d157360aabb1f0585911942661e0904
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604337/?tool=EBI

The developmental stage of the medulloblastoma cell-of-origin restricts Hedgehog pathway usage and drug sensitivity

Autor: Marlinde J. Smit, Inna Armandari, Irena Bockaj, Tosca E.I. Martini, Walderik W. Zomerman, Zillah Siragna, Tiny G.J. Meeuwsen, Frank J.G. Scherpen, Mirthe H. Schoots, Martha Ritsema, Wilfred F.A. den Dunnen, Eelco W. Hoving, Judith T.M.L. Paridaen, Gerald de Haan, Victor Guryev, Sophia W.M. Bruggeman

SummarySonic Hedgehog (SHH) medulloblastoma originates from the cerebellar granule neuron progenitor (CGNP) lineage that depends on Hedgehog signaling for its perinatal expansion. While SHH tumors exhibit overall deregulation of this pathway, they al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::535a36301885b2630f59fe6d1ed84097
https://doi.org/10.1101/2021.01.22.427790