Mutation of the glycine residue preceding the sixth tyrosine of the LAT adaptor severely alters T cell development and activation

Autor: Mikel M. Arbulo-Echevarria, Inmaculada Vico-Barranco, Fanghui Zhang, Luis M. Fernandez-Aguilar, Martyna Chotomska, Isaac Narbona-Sánchez, Lichen Zhang, Bernard Malissen, Yinming Liang, Enrique Aguado

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

The LAT transmembrane adaptor is essential to transduce intracellular signals triggered by the TCR. Phosphorylation of its four C-terminal tyrosine residues (136, 175, 195, and 235 in mouse LAT) recruits several proteins resulting in the assembly of

Externí odkaz: https://doaj.org/article/83670c39e1304dc497eced2cd74e5e7d

Increased Protein Stability and Interleukin-2 Production of a LATG131D Variant With Possible Implications for T Cell Anergy

Autor: Mikel M. Arbulo-Echevarria, Inmaculada Vico-Barranco, Isaac Narbona-Sánchez, Francisco García-Cózar, Arkadiusz Miazek, Enrique Aguado

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 8 (2020)

The adaptor LAT plays a crucial role in the transduction of signals coming from the TCR/CD3 complex. Phosphorylation of some of its tyrosines generates recruitment sites for other cytosolic signaling molecules. Tyrosine 132 in human LAT is essential

Externí odkaz: https://doaj.org/article/933a3127c8b144a3aa1f0746ecfad26a

A Stretch of Negatively Charged Amino Acids of Linker for Activation of T-Cell Adaptor Has a Dual Role in T-Cell Antigen Receptor Intracellular Signaling

Autor: Mikel M. Arbulo-Echevarria, Isaac Narbona-Sánchez, Cecilia M. Fernandez-Ponce, Inmaculada Vico-Barranco, Mª Dolores Rueda-Ygueravide, Michael L. Dustin, Arkadiusz Miazek, Mª Carmen Duran-Ruiz, Francisco García-Cózar, Enrique Aguado

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

The adaptor protein linker for activation of T cells (LAT) has an essential role transducing activatory intracellular signals coming from the TCR/CD3 complex. Previous reports have shown that upon T-cell activation, LAT interacts with the tyrosine ki

Externí odkaz: https://doaj.org/article/36a9285d1dc445a9a6abb348a64bbff6

A Novel, LAT/Lck Double Deficient T Cell Subline J.CaM1.7 for Combined Analysis of Early TCR Signaling

Autor: Arkadiusz Miazek, Enrique Aguado, Inmaculada Vico-Barranco, Alba Pérez-Linaza, Isaac Narbona-Sánchez, Mikel M Arbulo-Echevarria, Jose Maria Miranda-Sayago, Isabel Serrano-García

Publikováno v: Cells, Vol 10, Iss 343, p 343 (2021)
Cells 2021, 10(2), 343
RODIN. Repositorio de Objetos de Docencia e Investigación de la Universidad de Cádiz
instname
Cells
Volume 10
Issue 2
RODIN: Repositorio de Objetos de Docencia e Investigación de la Universidad de Cádiz
Universidad de Cádiz

Intracellular signaling through the T cell receptor (TCR) is essential for T cell development and function. Proper TCR signaling requires the sequential activities of Lck and ZAP-70 kinases, which result in the phosphorylation of tyrosine residues lo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8de2151aa531232696f28dcac3111017
https://www.mdpi.com/2073-4409/10/2/343