Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Inmaculada Serramito-Gómez"'
Autor:
Inmaculada Serramito-Gómez, Emilio Boada-Romero, Raquel Villamuera, Álvaro Fernández-Cabrera, José Luis Cedillo, Ángela Martín-Regalado, Simon Carding, Uli Mayer, Penny P. Powell, Thomas Wileman, Irene García-Higuera, Felipe X. Pimentel-Muiños
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The WD40 domain of ATG16L1 is thought to be involved in non-canonical autophagy. Here the authors screen peptide libraries and identify interactions between this domain and the IL-2Rγ and IL-10RB receptors, indicating endosomal regulation of cytokin
Externí odkaz:
https://doaj.org/article/f827951d5bc9452e960cbed014b2d5d6
Autor:
Karolina Slowicka, Inmaculada Serramito-Gómez, Emilio Boada-Romero, Arne Martens, Mozes Sze, Ioanna Petta, Hanna K. Vikkula, Riet De Rycke, Eef Parthoens, Saskia Lippens, Savvas N. Savvides, Andy Wullaert, Lars Vereecke, Felipe X. Pimentel-Muiños, Geert van Loo
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Maintaining the intestinal barrier function requires a balance of multiple signalling pathways. Here the authors show that A20, an anti-inflammatory and anti-apoptotic protein, and Atg1611, an autophagy regulator, cross-regulate their respective prot
Externí odkaz:
https://doaj.org/article/66f4ba80a7fd4950b7b10906aec986dc
Autor:
Inmaculada Serramito-Gómez, Kathryn M. Clarke, Ana Eugenia Rodríguez-Vicente, Julie E. McGimpsey, María Abáigar, Carlos Barranquero Díez, Rocío Benito, Lars Bullinger, Ken I. Mills, Jesús María Hernández Rivas
Publikováno v:
HemaSphere, Vol 5, Iss 3, p e541 (2021)
Externí odkaz:
https://doaj.org/article/85780076835943e3956a4a40756d5f73
Autor:
Emilio Boada-Romero, Inmaculada Serramito-Gómez, María P. Sacristán, David L. Boone, Ramnik J. Xavier, Felipe X. Pimentel-Muiños
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
The T300A substitution in ATG16L is associated with Crohn’s disease risk and disrupts clearance of intracellular pathogens by autophagy. Here the authors show that the mutation impairs interaction of ATG16L with TMEM59 and disrupts unconventional T
Externí odkaz:
https://doaj.org/article/34956e407de4444e99fd297358803333
Autor:
Inmaculada Serramito-Gómez, Elena Terraza-Silvestre, Álvaro Fernández-Cabrera, Raquel Villamuera, Felipe X. Pimentel-Muiños
Publikováno v:
Autophagy
A coding allele of ATG16L1 that increases the risk of Crohn disease (T300A; rs2241880) impairs the interaction between the C-terminal WD40 domain (WDD) and proteins containing a WDD-binding motif, thus specifically inhibiting the unconventional autop
Autor:
Jesús María Hernández Rivas, Ken I. Mills, Rocío Benito, María Abáigar, Inmaculada Serramito-Gómez, Ana E. Rodríguez-Vicente, Julie E. McGimpsey, Carlos Barranquero Díez, Lars Bullinger, Kathryn M. Clarke
Publikováno v:
Serramito-Gómez, I, Clarke, K M, Rodríguez-Vicente, A E, McGimpsey, J E, Abáigar, M, Díez, C B, Benito, R, Bullinger, L, Mills, K I & Hernández Rivas, J M 2021, ' NEMHESYS-European Perspective on the Implementation of Next-generation Sequencing Into Clinical Diagnostics ', HemaSphere, vol. 5, no. 3, e541 . https://doi.org/10.1097/HS9.0000000000000541
Digital.CSIC. Repositorio Institucional del CSIC
instname
HemaSphere
HemaSphere, Vol 5, Iss 3, p e541 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
HemaSphere
HemaSphere, Vol 5, Iss 3, p e541 (2021)
© 2021 the Author(s).
NGS Establishment in Multidisciplinary Healthcare (NEMHESYS) is an Erasmus+ programme with the purpose of providing qualified staff with the essential technical and bioinformatic knowledge and skills on next-generation seq
NGS Establishment in Multidisciplinary Healthcare (NEMHESYS) is an Erasmus+ programme with the purpose of providing qualified staff with the essential technical and bioinformatic knowledge and skills on next-generation seq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af98b691c2bf8c78094e8b807828ab56
https://pure.qub.ac.uk/en/publications/b5260283-baa4-435d-b4a7-47cb4e400ccb
https://pure.qub.ac.uk/en/publications/b5260283-baa4-435d-b4a7-47cb4e400ccb
Autor:
Raquel Villamuera, Alvaro Fernández-Cabrera, Elena Terraza-Silvestre, Rachid Taouil, Felipe X. Pimentel-Muiños, Inmaculada Serramito-Gómez
Publikováno v:
Autophagy
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
ATG16L1 is a critical mediator of macroautophagy/autophagy required for LC3 lipidation and autophagosome formation. However, ATG16L1 has a C-terminal domain including 7 WD40-type repetitions (WD40 domain, WDD) that is unnecessary for the conventional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec85dbff33b9a758f27ea4d61634a51a
http://hdl.handle.net/10261/262407
http://hdl.handle.net/10261/262407
Autor:
Emilio Boada-Romero, Lars Vereecke, Inmaculada Serramito-Gómez, Geert van Loo, Felipe X. Pimentel-Muiños, Karolina Slowicka
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications
instname
Nature Communications
The C-terminal domain of ATG16L1 includes 7 WD40-type repeats (WD40 domain, WDD) and is not required for canonical macroautophagy/autophagy. Instead, the WDD allows ATG16L1 to induce LC3/Atg8 lipidation in single-membrane compartments, although a det
Autor:
José María Bastida, José Ramón González-Porras, Lorena Díaz-Ajenjo, Rocío Benito, Ana Marín-Quílez, Elena Vuelta, Inmaculada Serramito-Gómez, Pedro Ruiz-Sala, Ignacio García-Tuñón, José Rivera, Sandra Santos-Mínguez, María Jesús Peñarrubia, Jesús María Hernández-Rivas, Verónica Palma-Barqueros, Cristina Miguel-García, Emilia Pardal, Daisy Castiñeiras-Ramos
Publikováno v:
Blood. 138:588-588
Introduction Inherited thrombocytopenias (ITs) are a heterogeneous group of rare platelet disorders. which lead not only to increased bleeding, but also to syndromic forms. ITs are caused by genetic alterations in megakaryopoiesis-related genes. In t
Autor:
Inmaculada Serramito Gómez
Publikováno v:
GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname
GREDOS: Repositorio Institucional de la Universidad de Salamanca
Universidad de Salamanca (USAL)
instname
GREDOS: Repositorio Institucional de la Universidad de Salamanca
Universidad de Salamanca (USAL)
[ES] La autofagia es una ruta de degradación celular que actúa como un mecanismo de control de calidad del citoplasma, eliminando agregados proteicos, orgánulos dañados y microorganismos invasores. Aunque la degradación aleatoria de citoplasma e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9641993d197e36bf47b59d73a86a061
http://hdl.handle.net/10366/143539
http://hdl.handle.net/10366/143539