Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Inmaculada C Villar"'
Autor:
Christopher J. Morris, Michael G. Rolf, Linda Starnes, Inmaculada C. Villar, Amy Pointon, Holly Kimko, Giovanni Y. Di Veroli
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Pharmaceutical companies routinely screen compounds for hemodynamics related safety risk. In vitro secondary pharmacology is initially used to prioritize compounds while in vivo studies are later used to quantify and translate risk to humans. This st
Externí odkaz:
https://doaj.org/article/8cc8e9c9676f413cbf55bed31991df2d
Autor:
Jale Yuzugulen, Julie A. Douthwaite, Elizabeth G. Wood, Inmaculada C. Villar, Nimesh S. A. Patel, James Jegard, Hubert Gaertner, Irène Rossitto-Borlat, Keith Rose, Oliver Hartley, Pedro R. Cutillas, Amrita Ahluwalia, Roger Corder
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Endothelin-1 (ET-1) is involved in the pathogenesis of cardiac and renal diseases, and in the progression of tumour growth in cancer, but current diagnosis and treatment remain inadequate. Peptides derived from the 212 amino acid precursor p
Externí odkaz:
https://doaj.org/article/c88405d4ef9a4272ab9b01473d274a6f
Autor:
Amie J Moyes, Finn Olav Levy, Inmaculada C Villar, Trygve Gulbrandsen, Adrian J. Hobbs, Eva Steiness, Kristen J. Bubb
Publikováno v:
British Journal of Pharmacology. 173:3386-3401
Background and purpose SER100 is a selective nociceptin receptor (NOP) agonist with sodium-potassium-sparing aquaretic and anti-natriuretic activity. This study was designed to characterize the functional cardiovascular pharmacology of SER100 in vitr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::828fce70ac1c3dc971024a8426a5d269
https://doi.org/10.1111/bph.13634
https://doi.org/10.1111/bph.13634
Autor:
Amrita Ahluwalia, Irène Rossitto-Borlat, Elizabeth G. Wood, Pedro R. Cutillas, Jale Yuzugulen, Nimesh S. A. Patel, Hubert François Gaertner, Inmaculada C Villar, Roger Corder, Keith Rose, Oliver Hartley, James Jegard, Julie A. Douthwaite
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Scientific Reports, Vol. 7, No 1 (2017) P. 4956
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Scientific Reports, Vol. 7, No 1 (2017) P. 4956
Endothelin-1 (ET-1) is involved in the pathogenesis of cardiac and renal diseases, and in the progression of tumour growth in cancer, but current diagnosis and treatment remain inadequate. Peptides derived from the 212 amino acid precursor preproendo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ac1f33a941fd32f84047ce2b3168ec3
https://doi.org/10.1038/s41598-017-05365-2
https://doi.org/10.1038/s41598-017-05365-2
Autor:
Inmaculada C, Villar, Kristen J, Bubb, Amie J, Moyes, Eva, Steiness, Trygve, Gulbrandsen, Finn Olav, Levy, Adrian J, Hobbs
Publikováno v:
British journal of pharmacology. 173(23)
SER100 is a selective nociceptin (NOP) receptor agonist with sodium-potassium-sparing aquaretic and anti-natriuretic activity. This study was designed to characterize the functional cardiovascular pharmacology of SER100 in vitro and in vivo, includin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d23261ccd0b729a2140cdcc647a647b1
https://pubmed.ncbi.nlm.nih.gov/27667485
https://pubmed.ncbi.nlm.nih.gov/27667485
Autor:
Alastair J. Noyce, Inmaculada C Villar, Amrita Ahluwalia, Ramona S. Scotland, Melissa V. Chan, Kristen J. Bubb, Adrian J. Hobbs, Johan Duchene
Publikováno v:
British Journal of Pharmacology. 167:805-817
BACKGROUND AND PURPOSE Pre-menopausal females have a lower incidence of cardiovascular disease compared with age-matched males, implying differences in the mechanisms and pathways regulating vasoactivity. In small arteries, myogenic tone (constrictio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c3f4cc63d0c20241802a160b046d20a
https://doi.org/10.1111/j.1476-5381.2012.02012.x
https://doi.org/10.1111/j.1476-5381.2012.02012.x
Autor:
Adil Sheraz, Adrian J. Hobbs, Inmaculada C Villar, Muriel Nobles, Catherine M Panayiotou, Melanie Madhani, Ramona S. Scotland, Barbara K Kemp-Harper, Amrita Ahluwalia
Publikováno v:
Cardiovascular Research. 74:515-525
Objective : C-type natriuretic peptide (CNP) has recently been suggested to represent an endothelium-derived hyperpolarising factor (EDHF) in the mammalian resistance vasculature and, as such, important in the regulation of local blood flow and syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9a2e527715293084c7b241fb00c2cf
https://doi.org/10.1016/j.cardiores.2007.02.032
https://doi.org/10.1016/j.cardiores.2007.02.032
Autor:
Amrita Ahluwalia, Reshma S. Baliga, Adrian J. Hobbs, Concepción Peiró, Roberta J. Worthington, Fernando Rivilla, Amie J Moyes, Paul J. Gane, Inmaculada C Villar, Filipa Mota, Natalie G. Lumsden, Snezana Djordjevic, Raymond J. MacAllister, Mark J. Caulfield, Susana Vallejo, Anne Sophie Rebstock, Fang Xiao, David L. Selwood, Carlos F. Sánchez Ferrer, Kristen J. Bubb, Michela I. Simone, Rayomand S. Khambata
Publikováno v:
The Journal of clinical investigation. 124(9)
The endothelium plays a fundamental role in maintaining vascular homeostasis by releasing factors that regulate local blood flow, systemic blood pressure, and the reactivity of leukocytes and platelets. Accordingly, endothelial dysfunction underpins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb059e71868067b469021249ee8c502c
https://pubmed.ncbi.nlm.nih.gov/25105365
https://pubmed.ncbi.nlm.nih.gov/25105365
Publikováno v:
The Journal of endocrinology. 197(3)
The vascular endothelium plays a crucial role in the regulation of vascular homeostasis by controlling vascular tone, coagulation, and inflammatory responses. These actions are exerted by endothelial factors including nitric oxide, prostacyclin, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1db12ea69c30ffd0e984f09a809cac03
https://pubmed.ncbi.nlm.nih.gov/18492811
https://pubmed.ncbi.nlm.nih.gov/18492811
Publikováno v:
The FASEB Journal. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f03ba1e4558db5531cb265a49790c22
https://doi.org/10.1096/fasebj.22.1_supplement.719.4
https://doi.org/10.1096/fasebj.22.1_supplement.719.4