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Protective variant for hippocampal atrophy identified by whole exome sequencing

Autor: Nho, Kwangsik, Kim, Sungeun, Risacher, Shannon L, Shen, Li, Corneveaux, Jason J, Swaminathan, Shanker, Lin, Hai, Ramanan, Vijay K, Liu, Yunlong, Foroud, Tatiana M, Inlow, Mark H, Siniard, Ashley L, Reiman, Rebecca A, Aisen, Paul S, Petersen, Ronald C, Green, Robert C, Jack, Clifford R, Weiner, Michael W, Baldwin, Clinton T, Lunetta, Kathryn L, Farrer, Lindsay A, MIRAGE (Multi-Institutional Research on Alzheimer Genetic Epidemiology) Study, Furney, Simon J, Lovestone, Simon, Simmons, Andrew, Mecocci, Patrizia, Vellas, Bruno, Tsolaki, Magda, Kloszewska, Iwona, Soininen, Hilkka, AddNeuroMed Consortium, McDonald, Brenna C, Farlow, Martin R, Ghetti, Bernardino, Indiana Memory and Aging Study, Huentelman, Matthew J, Saykin, Andrew J, Alzheimer's Disease Neuroimaging Initiative

Publikováno v: Annals of neurology, vol 77, iss 3

We used whole-exome sequencing to identify variants other than APOE associated with the rate of hippocampal atrophy in amnestic mild cognitive impairment. An in-silico predicted missense variant in REST (rs3796529) was found exclusively in subjects w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::9549ffd18469e36b8cdbeb00a6877fb2
https://escholarship.org/uc/item/2q05w4rq

Protective variant for hippocampal atrophy identified by whole exome sequencing.

Autor: Nho K; Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN; Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN., Kim S, Risacher SL, Shen L, Corneveaux JJ, Swaminathan S, Lin H, Ramanan VK, Liu Y, Foroud TM, Inlow MH, Siniard AL, Reiman RA, Aisen PS, Petersen RC, Green RC, Jack CR Jr, Weiner MW, Baldwin CT, Lunetta KL, Farrer LA, Furney SJ, Lovestone S, Simmons A, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, McDonald BC, Farlow MR, Ghetti B, Huentelman MJ, Saykin AJ

Publikováno v: Annals of neurology [Ann Neurol] 2015 Mar; Vol. 77 (3), pp. 547-52. Date of Electronic Publication: 2015 Feb 14.