Loss of adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22.

Autor: Yu Chen, Maud Vandereyken, Ian P Newton, Ignacio Moraga, Inke S Näthke, Mahima Swamy

Publikováno v: PLoS Biology, Vol 17, Iss 11, p e3000540 (2019)

Interleukin-22 (IL-22) is a critical immune defence cytokine that maintains intestinal homeostasis and promotes wound healing and tissue regeneration, which can support the growth of colorectal tumours. Mutations in the adenomatous polyposis coli gen

Externí odkaz: https://doaj.org/article/aaa7a36f8b9b432b9b99f8463fcd0a66

Paneth Cell-Rich Regions Separated by a Cluster of Lgr5+ Cells Initiate Crypt Fission in the Intestinal Stem Cell Niche.

Autor: Alistair J Langlands, Axel A Almet, Paul L Appleton, Ian P Newton, James M Osborne, Inke S Näthke

Publikováno v: PLoS Biology, Vol 14, Iss 6, p e1002491 (2016)

The crypts of the intestinal epithelium house the stem cells that ensure the continual renewal of the epithelial cells that line the intestinal tract. Crypt number increases by a process called crypt fission, the division of a single crypt into two d

Externí odkaz: https://doaj.org/article/d8c3df365ed946b6bbc43d3a10ca2035

Open Microscopy Environment and FindSpots: integrating image informatics with quantitative multidimensional image analysis

Autor: David A. Schiffmann, Dina Dikovskaya, Paul L. Appleton, Ian P. Newton, Douglas A. Creager, Chris Allan, Inke S. Näthke, Ilya G. Goldberg

Publikováno v: BioTechniques, Vol 41, Iss 2, Pp 199-208 (2006)

Biomedical research and drug development increasingly involve the extraction of quantitative data from digital microscope images, such as those obtained using fluorescence microscopy. Here, we describe a novel approach for both managing and analyzing

Externí odkaz: https://doaj.org/article/ce6caac7f1fb4215a9d38ba572b9b64a

Ultrasound mediated delivery of quantum dots from a proof of concept capsule endoscope to the gastrointestinal wall

Autor: Alan R. Prescott, Benjamin F. Cox, Gerard Cummins, Inke S. Näthke, Maya Thanou, Mihnea V. Turcanu, Ian P. Newton, Helen Mulvana, Sandy Cochran, Fraser Stewart, Marc P.Y. Desmulliez, Eddie Clutton

Publikováno v: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Stewart, F, Cummins, G, Turcanu, M V, Cox, B F, Prescott, A, Clutton, E, Newton, I P, Desmulliez, M P Y, Thanou, M, Mulvana, H, Cochrane, S & Nathke, I 2021, ' Ultrasound Mediated Delivery of Quantum Dots from a Proof of Concept Capsule Endoscope to the Gastrointestinal Wall ', Scientific Reports . https://doi.org/10.1038/s41598-021-82240-1

Biologic drugs, defined as therapeutic agents produced from or containing components of a living organism, are of growing importance to the pharmaceutical industry. Though oral delivery of medicine is convenient, biologics require invasive injections

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f9b162af27f7f524e695d5232c21a9f
https://doi.org/10.1038/s41598-021-82240-1

An Organoid-derived Cell Layer as an in vitro Model for US-mediated Drug Delivery Studies

Autor: Stavros Vlatakis, Driton Vllasaliu, Sandy Cochran, Alexandru C. Moldovan, Mihnea V. Turcanu, Inke S. Näthke, Maya Thanou

Publikováno v: 2020 IEEE International Ultrasonics Symposium (IUS).

Standard in vitro models to study intestinal drug absorption and delivery, including ultrasound (US)-mediated drug delivery, are grown from tumorous colon and rectum cells. However, the intestinal epithelium is a heterogeneous tissue and includes ste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3025eaad1ae4b494daa00b51258cf7fe
https://doi.org/10.1109/ius46767.2020.9251401