Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Inke, Bahr"'
Publikováno v:
Archiv der Pharmazie. 349:692-697
The pharmaceutical industry is faced with significant challenges in its efforts to discover new drugs that address unmet medical needs. Safety concerns and lack of efficacy are the two main technical reasons for attrition. Improved early research too
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f668cbc4e01f70f1d7feb5da33a08881
https://doi.org/10.1002/ardp.201600078
https://doi.org/10.1002/ardp.201600078
Publikováno v:
Archiv der Pharmazie. 349(9)
The pharmaceutical industry is faced with significant challenges in its efforts to discover new drugs that address unmet medical needs. Safety concerns and lack of efficacy are the two main technical reasons for attrition. Improved early research too
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eb0eadc3479842027025be83b2181977
https://pubmed.ncbi.nlm.nih.gov/27335205
https://pubmed.ncbi.nlm.nih.gov/27335205
Publikováno v:
ChemBioChem. 10:1163-1174
Unbiased: Chemical proteomics was used to profile compound interactions in an unbiased fashion. We present here the application of different compound-immobilization routes for decoding nonprotein kinase off-targets of the multitarget kinase inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adc48f6bcbe9ec50d0590ba5b8864dab
https://doi.org/10.1002/cbic.200800796
https://doi.org/10.1002/cbic.200800796
Publikováno v:
FEBS Letters. 580:3921-3930
F-Box proteins (FBPs) are variable adaptor proteins that earmark protein substrates for ubiquination and destruction by the proteasome. Through their N-terminal F-box motif, they couple specific protein substrates to a catalytic machinery known as SC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eabc23493f55eaeb1a889d065e9ee22f
https://doi.org/10.1016/j.febslet.2006.06.023
https://doi.org/10.1016/j.febslet.2006.06.023
Autor:
Christoph Bührer, Usan Thanabalasingam, Dietger Stibenz, Eckart Fleck, Nils Debus, Michael Hasbach, Kristof Graf, Inke Bahr, Michael Gräfe
Publikováno v:
European Journal of Immunology. 36:446-456
Serum concentrations of soluble L-selectin by far exceed those of other soluble adhesion molecules, and serum soluble L-selectin concentrations are remarkably stable upon prolonged storage. We present evidence for Ca(2+)-dependent binding interaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f76494f54f56c96473c895785293f17
https://doi.org/10.1002/eji.200425360
https://doi.org/10.1002/eji.200425360
Publikováno v:
Journal of Biological Chemistry. 279:34472-34480
The leukocyte adhesion molecule L-selectin has an important role in the initial steps of leukocyte extravasation during inflammation and lymphocyte homing. Its cytoplasmic domain is involved in signal transduction after L-selectin cross-linking and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58e893a70a3adaf62d5e91c694944507
https://doi.org/10.1074/jbc.m405916200
https://doi.org/10.1074/jbc.m405916200
Autor:
Elke Butt-Dörje, Armin Herkner, Katrin Marcus, Heike Schäfer, Inke Bahr, Silke Suer, Stefan Lehr, Albert Sickmann, Helmut E. Meyer
Publikováno v:
ELECTROPHORESIS. 22:1669-1676
Proteome studies are powerful tools to solve many different problems in metabolism, signal transduction, drug discovery, and other areas of interest in life sciences. Up to now, high-sensitive methods for protein identification after two-dimensional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e345fc8a2f1800aa2cc3222bee4184b7
https://doi.org/10.1002/1522-2683(200105)22:9<1669::aid-elps1669>3.0.co
https://doi.org/10.1002/1522-2683(200105)22:9<1669::aid-elps1669>3.0.co
Autor:
Martina Huber, Inke Bahr, Roman Hillig, Kai Licha, Susanne Bauer, Yvonne Stark, Volker Badock, Siegfried Baesler, Michael Schirner, Stefanie Urlinger
Publikováno v:
Acta crystallographica. Section F, Structural biology and crystallization communications. 63(Pt 3)
Tetrasulfocyanine (TSC) has been described as a fluorescent probe for tumour imaging. The complex of TSC and the Fab antibody fragment MOR03268 has been crystallized in three different crystal forms. MOR03268 was identified from the HuCAL GOLD librar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e342d7648b85cbfe5f78dec51893a987
https://pubmed.ncbi.nlm.nih.gov/17329818
https://pubmed.ncbi.nlm.nih.gov/17329818
Publikováno v:
Molecular and cellular endocrinology. 245(1-2)
The role of the ubiquitin/proteasome system in degrading nuclear hormone receptors and regulating their transcriptional function has emerged in the last few years. We identified the ubiquitin-specific protease USP10 as part of DNA-bound androgen rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b8c23ac26c286cc2b89169cc9578e3a
https://pubmed.ncbi.nlm.nih.gov/16368182
https://pubmed.ncbi.nlm.nih.gov/16368182
Autor:
Eva-Christina Müller, Jörn Krätzschmar, Inke Bahr, Martin R. Schneider, Anette Sommer, Hans-Dieter Pohlenz, Peter Donner, Andreas Becker, Martina Huber
Publikováno v:
Molecularcellular proteomics : MCP. 3(1)
In search of novel mechanisms leading to the development of antiestrogen-resistance in human breast tumors, we analyzed differences in the gene and protein expression pattern of the human breast carcinoma cell line T47D and its derivative T47D-r, whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34e91cbbbbc65b566a9966bfad45e8af
https://pubmed.ncbi.nlm.nih.gov/14557597
https://pubmed.ncbi.nlm.nih.gov/14557597