Výsledky vyhledávání - "Inka Pawlitzky"

Akademický článek

Assessing the safety, tolerability and efficacy of PLGA-based immunomodulatory nanoparticles in patients with advanced NY-ESO-1-positive cancers: a first-in-human phase I open-label dose-escalation study protocol

Autor: Mark R Middleton, Winald R Gerritsen, Ian Walters, Licia Rivoltini, Niven Mehra, Jeroen H A Creemers, Carl G Figdor, I Jolanda M de Vries, Uzi Gileadi, Inka Pawlitzky, Konstantina Grosios, Petronella B Ottevanger

Publikováno v: BMJ Open, Vol 11, Iss 11 (2021)

Introduction The undiminished need for more effective cancer treatments stimulates the development of novel cancer immunotherapy candidates. The archetypical cancer immunotherapy would induce robust, targeted and long-lasting immune responses while s

Externí odkaz: https://doaj.org/article/99367d590514408180426cfd3671d3b8

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Akademický článek

Analysis of mice lacking DNaseI hypersensitive sites at the 5' end of the IgH locus.

Autor: Thomas Perlot, Inka Pawlitzky, John P Manis, Ali A Zarrin, Peter H Brodeur, Frederick W Alt

Publikováno v: PLoS ONE, Vol 5, Iss 11, p e13992 (2010)

The 5' end of the IgH locus contains a cluster of DNaseI hypersensitive sites, one of which (HS1) was shown to be pro-B cell specific and to contain binding sites for the transcription factors PU.1, E2A, and Pax5. These data as well as the location o

Externí odkaz: https://doaj.org/article/52108ed4520d4e0b98e944c1d618696c

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Autor: Petronella B. Ottevanger, I. Jolanda M. de Vries, Uzi Gileadi, Mark R. Middleton, Jeroen H A Creemers, Carl G. Figdor, Konstantina Grosios, Niven Mehra, Licia Rivoltini, Inka Pawlitzky, Ian Walters, Winald R. Gerritsen

Publikováno v: BMJ Open, 11, 11
BMJ Open, 11
BMJ Open, Vol 11, Iss 11 (2021)
BMJ Open

IntroductionThe undiminished need for more effective cancer treatments stimulates the development of novel cancer immunotherapy candidates. The archetypical cancer immunotherapy would induce robust, targeted and long-lasting immune responses while si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdfa501c5dd2af92f287da51436aea4b
https://repository.ubn.ru.nl/handle/2066/244562

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TRIM28 Is an Epigenetic Barrier to Induced Pluripotent Stem Cell Reprogramming

Autor: Danielle Hulsman, Nienke A. de Vries, Waseem Akhtar, Ewa Gogola, Martijn A.J. Koppens, Cor Lieftink, Santiago Gisler, Roderick L. Beijersbergen, Inka Pawlitzky, Denise C. Miles, Maarten van Lohuizen, Ellen Tanger

Publikováno v: Stem Cells. 35:147-157

Since the discovery of induced pluripotent stem cells there has been intense interest in understanding the mechanisms that allow a somatic cell to be reprogrammed back to a pluripotent state. Several groups have studied the alterations in gene expres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::028d0a3592c8dcaf3ee7ae72b1581a17
https://doi.org/10.1002/stem.2453

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Identification of a Candidate Regulatory Element within the 5′ Flanking Region of the Mouse Igh Locus Defined by Pro-B Cell-Specific Hypersensitivity Associated with Binding of PU.1, Pax5, and E2A

Autor: Christina V. Angeles, Peter H. Brodeur, Inka Pawlitzky, Andrea M. Siegel, Michelle L. Stanton, Roy Riblet

Publikováno v: The Journal of Immunology. 176:6839-6851

The Igh locus is controlled by cis-acting elements, including Eμ and the 3′ IgH regulatory region which flank the C region genes within the well-studied 3′ part of the locus. Although the presence of additional control elements has been postulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88734fd7d549f9cd4bfee5370a2948fe
https://doi.org/10.4049/jimmunol.176.11.6839

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Sonic Hedgehog Is Required during an Early Phase of Oligodendrocyte Development in Mammalian Brain

Autor: Inka Pawlitzky, Dong-in Yuk, Timothy Vartanian, David H. Rowitch, J. O. Mora, Charles D. Stiles, John A. Alberta, Palma Iannarelli, Song-Kyu Park

Publikováno v: Molecular and Cellular Neuroscience. 18:434-441

Oligodendrocyte precursor development in the embryonic spinal cord is thought to be regulated by the secreted signal, Sonic hedgehog (Shh). Such precursors can be identified by the expression of Olig genes, encoding basic helix–loop–helix factors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a294d9ae43b79689e422cc40616ec3ad
https://doi.org/10.1006/mcne.2001.1026

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Polycomb group gene Ezh2 regulates mammary gland morphogenesis and maintains the luminal progenitor pool

Autor: Jost Seibler, Ellen Wientjens, Ewa M. Michalak, Alexandra M Pietersen, Jos Jonkers, Ellen Tanger, Maarten van Lohuizen, Inka Pawlitzky, Karim Nacerddine, Paulien Cornelissen-Steijger, Vincent Beuger

Publikováno v: Stem cells (Dayton, Ohio). 31(9)

Specification of the cellular hierarchy in the mammary gland involves complex signaling that remains poorly defined. Polycomb group proteins are known to contribute to the maintenance of stem cell identity through epigenetic modifications, leading to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ebbdfe6c3035c261a0389bb5f61f29f
https://pubmed.ncbi.nlm.nih.gov/23712803

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