Zobrazeno 1 - 10
of 240
pro vyhledávání: '"Injae, Shin"'
Autor:
Kihyoun Park, Injae Shin, Yoonseon Kim, Hyereen Kang, Soo-Jin Oh, Eunkyeong Jang, Taebo Sim, Jeehee Youn, Myung-Shik Lee
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
BackgroundSince NEK7 is critical for NLRP3 inflammasome activation, NEK7 inhibitors could be employed as therapeutic agents against gout, a representative disease caused by NLRP3 inflammasome.MethodsWe designed NEK7 inhibitors based on biochemical ki
Externí odkaz:
https://doaj.org/article/e54b04d9a99a4f47b6bca4d955a248b0
Autor:
Junghwa Seo, Yeolhoe Kim, Suena Ji, Han Byeol Kim, Hyeryeon Jung, Eugene C. Yi, Yong-ho Lee, Injae Shin, Won Ho Yang, Jin Won Cho
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Necroptosis is a type of cell death with excessive inflammation and organ damage in various human diseases. Although abnormal necroptosis is common in patients with neurodegenerative, cardiovascular, and infectious diseases, the mechanisms by which O
Externí odkaz:
https://doaj.org/article/4fe9f76e86f5401db95a5a9f89b10938
Publikováno v:
Frontiers in Chemistry, Vol 11 (2023)
O-GlcNAc modification of proteins often has crosstalk with protein phosphorylation. These posttranslational modifications are highly dynamic events that modulate a wide range of cellular processes. Owing to the physiological and pathological signific
Externí odkaz:
https://doaj.org/article/e1100c5a02624fc1acaa9cbaa8096183
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 24, Iss 1, Pp 34-49 (2022)
Hepatocellular carcinoma (HCC) is disease with a high mortality rate and limited treatment options. Alterations of fibroblast growth factor receptor 4 (FGFR4) has been regarded as an oncogenic driver for HCC and a promising target for HCC therapeutic
Externí odkaz:
https://doaj.org/article/e355c3f209df48bb95c0874512458e1d
Autor:
Namkyoung Kim, Injae Shin, Younghoon Kim, Eunhye Jeon, Jiwon Lee, Chaeyoung Lee, Yunju Nam, Sumin Lee, Eunhye Ju, Chan Kim, Woolim Son, SeongShick Ryu, Minjoo Ko, Taebo Sim
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
RAS mutants are involved in approximately 30% of all human cancers and have been regarded as undruggable targets owing to relatively smooth protein surface and obscure binding pockets. In our previous study, we have demonstrated that GNF-7, a multi-t
Externí odkaz:
https://doaj.org/article/ab077dce29e646abaf028b086d8ff2d9
Publikováno v:
ACS Omega, Vol 4, Iss 5, Pp 8188-8195 (2019)
Externí odkaz:
https://doaj.org/article/128043bb2e8342f4b506d5533a589749
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100349- (2021)
Summary: Hsp70 inhibitors have great potential as chemical probes and anticancer agents. Thus, it is important to elucidate their modes of action on cancer cell death. This protocol describes a step-by-step process for the synthesis of apoptozole as
Externí odkaz:
https://doaj.org/article/064f77619a9047399547b6ae417a0a48
Autor:
Seong-Hyun Park, Won-Je Kim, Hui Li, Wonil Seo, Sang-Hyun Park, Hwan Kim, Sang Chul Shin, Erik R. P. Zuiderweg, Eunice EunKyeong Kim, Taebo Sim, Nak-Kyoon Kim, Injae Shin
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract In this study we examined the anti-leukemia activity of a small molecule inhibitor of Hsp70 proteins, apoptozole (Az), and hybrids in which it is linked to an inhibitor of either Hsp90 (geldanamycin) or Abl kinase (imatinib). The results of
Externí odkaz:
https://doaj.org/article/c293a04a3a7f4e7ea36a495332a1bd11
Publikováno v:
Chemical Society Reviews. 51:8957-9008
Near-infrared (NIR) fluorophores have unique features that endow them with several advantages over conventional shorter wavelength emitting dyes. As a result, they have been widely utilized as fluorescence and photoacoustic imaging agents, as well as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a62231c62b10f7b779688751d2240b9
https://doi.org/10.1039/d2cs00722c
https://doi.org/10.1039/d2cs00722c
Publikováno v:
Chemical Communications. 58:6336-6339
A novel fluorogenic probe for facile and efficient detection of a target protein that binds to a bioactive small molecule was developed. The probe was composed of a thiol-activated fluorogenic moiety bearing an alkyne tag and a protein binding ligand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d61d48f3fe3404fcc3df761d00c9e9b
https://doi.org/10.1039/d2cc02029g
https://doi.org/10.1039/d2cc02029g