Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Inhou Chu"'
Autor:
Mihirbaran Mandal, Li Xiao, Weidong Pan, Giovanna Scapin, Guoqing Li, Haiqun Tang, Shu-Wei Yang, Jianping Pan, Yuriko Root, Reynalda Keh de Jesus, Christine Yang, Winnie Prosise, Priya Dayananth, Asra Mirza, Alex G. Therien, Katherine Young, Amy Flattery, Charles Garlisi, Rumin Zhang, Donald Chu, Payal Sheth, Inhou Chu, Jin Wu, Carrie Markgraf, Hai-Young Kim, Ronald Painter, Todd W. Mayhood, Edward DiNunzio, Daniel F. Wyss, Alexei V. Buevich, Thierry Fischmann, Alexander Pasternak, Shuzhi Dong, Jacqueline D. Hicks, Artjohn Villafania, Lianzhu Liang, Nicholas Murgolo, Todd Black, William K. Hagmann, Jim Tata, Emma R. Parmee, Ann E. Weber, Jing Su, Haifeng Tang
Publikováno v:
Journal of Medicinal Chemistry. 65:16234-16251
With the emergence and rapid spreading of NDM-1 and existence of clinically relevant VIM-1 and IMP-1, discovery of pan inhibitors targeting metallo-beta-lactamases (MBLs) became critical in our battle against bacterial infection. Concurrent with our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f72a226d0f459e4620537979c8da4d4d
https://doi.org/10.1021/acs.jmedchem.2c00766
https://doi.org/10.1021/acs.jmedchem.2c00766
Autor:
Dmitri A. Pissarnitski, Zhiqiang Zhao, Mary Cohen-Williams, Troy McCraken, Lili Zhang, George Sun, Wei Zhou, Mihirbaran Mandal, Hongmei Li, Xianhai Huang, Duane A. Burnett, Zhaoning Zhu, Xiaoxiang Liu, Inhou Chu, Anandan Palani, Robert G. Aslanian, John W. Clader, Gallo Gioconda, Lynn A. Hyde, Chad Bennett, David Cole, Monica Vicarel, Alexei V. Buevich, Michael Czarniecki, William J. Greenlee, Lixin Song, Xiaohong Zhu
Publikováno v:
ACS Medicinal Chemistry Letters. 3:931-935
Fused oxadiazines (3) were discovered as selective and orally bioavailable γ-secretase modulators (GSMs) based on the structural framework of oxadiazoline GSMs. Although structurally related, initial modifications showed that structure-activity rela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3575eaf01068003a61b49639e08f3779
https://doi.org/10.1021/ml300209g
https://doi.org/10.1021/ml300209g
Autor:
Xianhai Huang, Eric M. Parker, Xiaoxiang Liu, Gioconda V. Gallo, Thomas A. Bara, Lili Zhang, Lixin Song, Ruo Xu, Hongmei Li, William J. Greenlee, Troy Mccracken, Xiaohong Zhu, Theodros Asberom, Nicholas Jones, Monica L. Vicarel, Mihir B. Mandal, Julie Lee, Zhaoning Zhu, Qi Zhang, John W. Clader, Dmitri A. Pissarnitski, Mary Cohen-Williams, Lynn A. Hyde, Johannes H. Voigt, Irina Kazakevich, James Durkin, Jun Qin, Michael Czarniecki, Hubert B. Josien, Amin A. Nomeir, Duane A. Burnett, Chad E. Bennett, Zhong-Yue Sun, Robert Mazzola, Giuseppe Terracina, David Cole, Zhiqiang Zhao, Inhou Chu, Malcolm Maccoss, Anandan Palani
Publikováno v:
Journal of Medicinal Chemistry. 55:489-502
Cyclic hydroxyamidines were designed and validated as isosteric replacements of the amide functionality. Compounds with these structural motifs were found to be metabolically stable and to possess highly desirable pharmacokinetic profiles. These desi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c0f39de1cb62f536e58373ca41057aa
https://doi.org/10.1021/jm201407j
https://doi.org/10.1021/jm201407j
Autor:
Galya Vassileva, Petro Mary E, Long Cui, Inhou Chu, Satwant K. Narula, Andrei Golovko, Lily Yang, Amin A. Nomeir, Catherine Pugliese-Sivo, Paul J. Zavodny, Li-Kang Zhang, Joseph A. Kozlowski, Xian Liang, Chuan-Chu Chou, Eva-Pia Reich
Publikováno v:
European Journal of Immunology. 35:1027-1036
The KCNN4 potassium-ion channel has been reported to play an important role in regulating antigen-induced T cell effector functions in vitro. This study presents the first evidence that a selective KCNN4 blocker, TRAM-34, confers protection against e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5698f5b7c12e773218892db03ee8d7f4
https://doi.org/10.1002/eji.200425954
https://doi.org/10.1002/eji.200425954
Autor:
Sheng Zhang, Tongtong Liu, Eliza Fung, Cheng Li, Jack Henion, Inhou Chu, Walter A. Korfmacher, Colleen K. Van Pelt
Publikováno v:
Rapid Communications in Mass Spectrometry. 17:1573-1578
Caco-2 cells offer a means to rapidly screen permeability of drug candidates, allowing pharmaceutical companies to eliminate candidates unable to cross the intestinal barrier early in the discovery process. This screening process is typically perform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7f3c2f80dab92ee0729509a0d347b54
https://doi.org/10.1002/rcm.1087
https://doi.org/10.1002/rcm.1087
Autor:
Tony Soares, Inhou Chu, Roger J. Smith, I.Y. Rosenblum, George Mandakas, Jairam Palamanda, Federico M Goodsaid, Zhiling Li, Kevin B. Alton, Laura Norton, Chunyan Gu, Diana Montgomery, Narendra S. Kishnani, Xiaoli You
Publikováno v:
Pharmaceutical Research. 20:1373-1380
Purpose. A conventional approach to assess cytochrome P450 (CYP) induction in preclinical animal models involves daily dosing for a least a week followed by Western blot and/or enzyme activity analysis. To evaluate the potential benefit of a third mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e165faff07cb9ee0b0ad635147b2aa8
https://doi.org/10.1023/a:1025793707794
https://doi.org/10.1023/a:1025793707794
Publikováno v:
Rapid Communications in Mass Spectrometry. 16:1501-1505
Rapid, generic gradient liquid chromatography/tandem mass spectrometry (LC/MS/MS) assays, designed to accelerate sample analyses, have been developed to keep pace with the productivity of advanced synthetic procedures. In this study, LC/MS/MS was com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea291a6b78e48cb6b1f83812ab2bea2a
https://doi.org/10.1002/rcm.738
https://doi.org/10.1002/rcm.738
Autor:
Gopal Krishna, Elpida Sapidou, Chin-Chung Lin, Inhou Chu, Cliff Chen, Laura Norton, A. D. Soares, Yau Yi Lau, Yumibe Nathan P, Diane E. Grotz
Publikováno v:
Pharmaceutical Research. 19:1606-1610
Purpose. The in vivo hepatic extraction ratio of cynomolgus monkeys was correlated with the corresponding in vitro extraction ratios that were determined in monkey microsomal incubations.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e46ba845ef3398d1e5c7a727f3095fa2
https://doi.org/10.1023/a:1020765025857
https://doi.org/10.1023/a:1020765025857
Publikováno v:
Rapid Communications in Mass Spectrometry. 14:207-214
In the early stage of drug discovery, thousands of new chemical entities (NCEs) may be screened before a single drug candidate can be identified for development. In order to accelerate the drug discovery process, we have developed higher-throughput e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4311846e5302b35c118a265f3c69960c
https://doi.org/10.1002/(sici)1097-0231(20000229)14:4<207::aid-rcm863>3.0.co
https://doi.org/10.1002/(sici)1097-0231(20000229)14:4<207::aid-rcm863>3.0.co
Publikováno v:
Journal of Chromatography A. 755:281-288
A systematic and comprehensive study of the separation and quantification of two dimeric catharanthus alkaloids, vincristine (VC) and vinblastine (VB), in Catharanthus leaves by capillary zone electrophoresis (CZE) was conducted. Various separation p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da94b8331f6e4fd5a6d3bbcbaf1773cf
https://doi.org/10.1016/s0021-9673(96)00614-0
https://doi.org/10.1016/s0021-9673(96)00614-0