Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Inha, Heo"'
Autor:
Jordi Doijen, Koen Temmerman, Christel Van den Eynde, Annick Diels, Nick Van den Broeck, Michiel Van Gool, Inha Heo, Steffen Jaensch, Marleen Zwaagstra, Mayra Diosa Toro, Winston Chiu, Steven De Jonghe, Pieter Leyssen, Denisa Bojkova, Sandra Ciesek, Jindrich Cinatl, Lore Verschueren, Christophe Buyck, Frank Van Kuppeveld, Johan Neyts, Marnix Van Loock, Ellen Van Damme
Publikováno v:
Microorganisms, Vol 11, Iss 3, p 717 (2023)
The ongoing COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is partly under control by vaccination. However, highly potent and safe antiviral drugs for SARS-CoV-2 are still needed to avoid development of sev
Externí odkaz:
https://doaj.org/article/c44476726dbf4c47a12d38fe05172f8d
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
The RNA binding protein TRBP is a component of the Dicer complex but its role in microRNA biogenesis remains poorly understood. Here the authors use a crowded RNA environment and single-molecule imaging to show that TRBP acts as a gatekeeper to preve
Externí odkaz:
https://doaj.org/article/7b1687162fec4a0bb83eed9b2f3f28d3
Autor:
Inha Heo, Hans Clevers, Ninouk Akkerman, Adriana Martinez-Silgado, Aurelia Saftien, Cayetano Pleguezuelos-Manzano, Charelle Boot, Joep Beumer, Amy de Waal, Devanjali Dutta, Jens Puschhof
Publikováno v:
Nature Protocols. 16(10):4633-4649
Adult-stem-cell-derived organoids model human epithelial tissues ex vivo, which enables the study of host–microbe interactions with great experimental control. This protocol comprises methods to coculture organoids with microbes, particularly focus
Autor:
Michael R. Lazear, Jarrett R. Remsberg, Martin G. Jaeger, Katherine Rothamel, Hsuan-lin Her, Kristen E. DeMeester, Evert Njomen, Simon J. Hogg, Jahan Rahman, Landon R. Whitby, Sang Joon Won, Michael A. Schafroth, Daisuke Ogasawara, Minoru Yokoyama, Garrett L. Lindsey, Haoxin Li, Jason Germain, Sabrina Barbas, Joan Vaughan, Thomas W. Hanigan, Vincent F. Vartabedian, Christopher J. Reinhardt, Melissa M. Dix, Seong Joo Koo, Inha Heo, John R. Teijaro, Gabriel M. Simon, Brahma Ghosh, Omar Abdel-Wahab, Kay Ahn, Alan Saghatelian, Bruno Melillo, Stuart L. Schreiber, Gene W. Yeo, Benjamin F. Cravatt
SummaryMost human proteins lack chemical probes, and several large-scale and generalizable small-molecule binding assays have been introduced to address this problem. How compounds discovered in such “binding-first” assays affect protein function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d07f22999c7fd8b3058ebc700cdfeab3
https://doi.org/10.1101/2022.12.12.520090
https://doi.org/10.1101/2022.12.12.520090
Autor:
Jens, Puschhof, Cayetano, Pleguezuelos-Manzano, Adriana, Martinez-Silgado, Ninouk, Akkerman, Aurelia, Saftien, Charelle, Boot, Amy, de Waal, Joep, Beumer, Devanjali, Dutta, Inha, Heo, Hans, Clevers
Publikováno v:
Nature protocols. 16(10)
Adult-stem-cell-derived organoids model human epithelial tissues ex vivo, which enables the study of host-microbe interactions with great experimental control. This protocol comprises methods to coculture organoids with microbes, particularly focusin
Autor:
Kim E Boonekamp, Antoni P. A. Hendrickx, Benedetta Artegiani, Deborah A. Schaefer, Michael W. Riggs, Inha Heo, Devanjali Dutta, Robert J L Willems, Nino Iakobachvili, Roberta M. O'Connor, Gregory D. Bowden, Hans Clevers, Norman Sachs, Peter J. Peters
Publikováno v:
Nature Microbiology, 3(7), 814-823. Nature Publishing Group
Nature Microbiology, 3(7), 814. Nature Publishing Group
Nature Microbiology
Nature Microbiology, 3(7), 814. Nature Publishing Group
Nature Microbiology
Stem-cell-derived organoids recapitulate in vivo physiology of their original tissues, representing valuable systems to model medical disorders such as infectious diseases. Cryptosporidium, a protozoan parasite, is a leading cause of diarrhoea and a
Publikováno v:
Journal of visualized experiments : JoVE. (151)
Cryptosporidium parvum is one of the major causes of human diarrheal disease. To understand the pathology of the parasite and develop efficient drugs, an in vitro culture system that recapitulates the conditions in the host is needed. Organoids, whic
Publikováno v:
Trends in Molecular Medicine, 23(5), 393-410. Elsevier B.V.
Trends in molecular medicine, 23(5), 393. Elsevier Limited
Trends in molecular medicine, 23(5), 393. Elsevier Limited
Organoids are 3D in vitro culture systems derived from self-organizing stem cells. They can recapitulate the in vivo architecture, functionality, and genetic signature of original tissues. Thus, organoid technology has been rapidly applied to underst
Autor:
Egbert F. Smit, Maarten van der Linden, Emile E. Voest, Sander J. Tans, Fleur Weeber, Luc Teeven, Joep de Ligt, Linde Meyaard, Edwin Cuppen, G. Johan A. Offerhaus, Johanna F. Dekkers, Norman Sachs, Peter J. Peters, Sylvia F. Boj, Gimano D. Amatngalim, Domenique D. Zomer-van Ommen, Emilio Ramos, Matthijs F.M. van Oosterhout, Alexander van Oudenaarden, Coline H.M. van Moorsel, Robert G.J. Vries, Marco C. Viveen, Eduardo P. Olimpio, Natalie Proost, Arne Van Hoeck, Anne C. Rios, Dominique J Wiener, Krijn K. Dijkstra, Frank E. J. Coenjaerts, Guizela Huelsz-Prince, Lena Böttinger, Harry Begthel, Marieke van de Ven, Jos Jonkers, Jeroen Korving, Sepideh Derakhshan, Sridevi Jaksani, Anna Lyubimova, Louis Bont, Cornelis K. van der Ent, Angelos Papaspyropoulos, Jeroen S. van Zon, Nino Iakobachvili, Hans Clevers, Dymph Klay, Inha Heo, Kuldeep Kumawat, Jeffrey M. Beekman
Publikováno v:
EMBO Journal, 38(4). Nature Publishing Group
The Embo Journal, 38(4):100300. Wiley
The Embo Journal, 38(4):100300. Wiley
Organoids are self-organizing 3D structures grown from stem cells that recapitulate essential aspects of organ structure and function. Here, we describe a method to establish long-term-expanding human airway organoids from broncho-alveolar resections
Autor:
Daniel Postrach, Danielle Seinstra, Benedetta Artegiani, Michiel Vermeulen, Ruben van Boxtel, Peter J. Peters, Huili Hu, Carmen López-Iglesias, Rurika Oka, Talya L. Dayton, Johan H. van Es, Hans Clevers, Johan Offerhaus, Rik G.H. Lindeboom, Jacco van Rheenen, Pablo Tapia, Inha Heo, Lisa van Voorthuijsen
Publikováno v:
Cell Stem Cell, 24, 927-943, e1-e6
Cell Stem Cell, 24(6), 927-943.e6. Cell Press
Cell Stem Cell
Cell Stem Cell, 24, 6, pp. 927-943, e1-e6
Cell Stem Cell, 24(6), 927-943.e6. Cell Press
Cell Stem Cell
Cell Stem Cell, 24, 6, pp. 927-943, e1-e6
The deubiquitinating enzyme BAP1 is a tumor suppressor, among others involved in cholangiocarcinoma. BAP1 has many proposed molecular targets, while its Drosophila homolog is known to deubiquitinate histone H2AK119. We introduce BAP1 loss-of-function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::608471d87f9721527191867a4b3a688d
http://hdl.handle.net/2066/204500
http://hdl.handle.net/2066/204500