Výsledky vyhledávání - "Ingvar Ferby"

Ligand-independent role of ErbB3 in endocytic recycling

Autor: Takeshi Terabayashi, Ana Rosa Saez-Ibañez, Olof Idevall-Hagren, Julia M. Scheffler, Ingvar Ferby

Activated receptor tyrosine kinases (RTKs) are important cargo of the endocytic trafficking, yet to what extent RTKs play a role in endocytic trafficking processes per se, remains unclear. Here we show that the ErbB3 receptor, frequently overexpresse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a91b746ade1968084189703133aa116

Zobrazit plný text záznamu

The Tumor Suppressor MIG6 Controls Mitotic Progression and the G2/M DNA Damage Checkpoint by Stabilizing the WEE1 Kinase

Autor: Mari, Sasaki, Takeshi, Terabayashi, Stefanie M, Weiss, Ingvar, Ferby

Publikováno v: Cell reports. 24(5)

MIG6 is an important tumor suppressor that binds to and negatively regulates epidermal growth factor receptor (EGFR). Here, we report an EGFR-independent function for MIG6 as an integral component of the cell cycle machinery. We found that depletion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1a7cae71b054177a4a1fd7bd0129ced2
https://pubmed.ncbi.nlm.nih.gov/30067982

Zobrazit plný text záznamu

Mitogen-inducible gene-6 is a negative regulator of epidermal growth factor receptor signaling in hepatocytes and human hepatocellular carcinoma

Autor: Ewa Stepniak, Markus Reschke, Ingvar Ferby, Erwin F. Wagner, David Horst, Nina Seitzer, Axel Ullrich

Publikováno v: Hepatology. 51:1383-1390

The mitogen-inducible gene-6 (mig-6) is a multi-adaptor protein implicated in the regulation of the HER family of receptor tyrosine kinases. We have reported recently that mig-6 is a negative regulator of epidermal growth factor receptor (EGFR)-depen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1c2dc10cb3a937c2eaa694da4788c79
https://doi.org/10.1002/hep.23428

Zobrazit plný text záznamu

Regulation of the meiotic cell cycle in oocytes

Autor: Ingvar Ferby, Angel R. Nebreda

Publikováno v: Current Opinion in Cell Biology. 12:666-675

The mitotic and meiotic cell cycle share many regulators, but there are also important differences between the two processes. The meiotic maturation of Xenopus oocytes has proved useful for understanding the regulation of Cdc2-cyclin-B, a key activat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11941795bce48f1ff25b9bd55954c882
https://doi.org/10.1016/s0955-0674(00)00150-2

Zobrazit plný text záznamu

Activated Cdc42-associated kinase 1 (Ack1) is required for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor recruitment to lipid rafts and induction of cell death

Autor: Nupam P. Mahajan, Emma Linderoth, Giulia Pilia, Ingvar Ferby

Publikováno v: The Journal of biological chemistry. 288(46)

TNF-related apoptosis-inducing ligand (TRAIL) holds promise for treatment of cancer due to its ability to selectively kill cancer cells while sparing normal cells. Ligand-induced translocation of TRAIL receptors (TRAIL-R) 1 and 2 (also called DR4 and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2be9ae4c8eb1b0baedb8d8bcef0543d5
https://pubmed.ncbi.nlm.nih.gov/24085293

Zobrazit plný text záznamu

Micro-trap phosphorylation assay of mitogen-activated protein (MAP) kinases to detect their activation by lipopolysaccharides

Autor: Ingvar Ferby, Iwao Waga, Takao Shimizu, Kazuhiko Kume, Zen-ichiro Honda

Publikováno v: Journal of Immunological Methods. 190:71-77

We designed a microplate-based assay method for mitogen-activated protein (MAP) kinase. Using anion-exchanger resin, MAP kinases from murine macrophages were partially purified in 96-well plates. The activities of these purified enzymes correlated we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dd1c883a73ecc7e992a9891b7d55586
https://doi.org/10.1016/0022-1759(95)00266-9

Zobrazit plný text záznamu

Mig6 is a sensor of EGF receptor inactivation that directly activates c-Abl to induce apoptosis during epithelial homeostasis

Autor: Giulio Superti-Furga, Giulia Pilia, Paula Suarez-Henriques, Sarah Hopkins, Oliver Hantschel, Howard Kendrick, Matthew J. Smalley, Emma Linderoth, Ingvar Ferby

Publikováno v: Developmental Cell

Summary A fundamental aspect of epithelial homeostasis is the dependence on specific growth factors for cell survival, yet the underlying mechanisms remain obscure. We found an “inverse” mode of receptor tyrosine kinase signaling that directly li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49fd334d532c05588968953b1305bd11
https://orca.cardiff.ac.uk/id/eprint/37471/1/OA-110.pdf

Zobrazit plný text záznamu

Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation

Autor: Axel Ullrich, Reinhard Fässler, Norbert Kraut, Pjotr Knyazev, Rüdiger Klein, Ingvar Ferby, Guido Pante, Wolfgang Sommergruber, Markus Reschke, Oliver Kudlacek, Kerstin Amann

Publikováno v: Nature medicine. 12(5)

The growing number of recently identified negative feedback regulators of receptor tyrosine kinases (RTKs) highlights the importance of signal attenuation and modulation for correct signaling outcome. Mitogen-inducible gene 6 (Mig6 also known as RALT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4586b48c0a1bb14c5292e841909ab79a
https://pubmed.ncbi.nlm.nih.gov/16648858

Zobrazit plný text záznamu

Mitogen-inducible gene 6 is an endogenous inhibitor of HGF/Met-induced cell migration and neurite growth

Autor: Ingvar Ferby, Alun M. Davies, Fabienne Lamballe, Guido Pante, Tomoko Iwata, Jane Thompson, Rüdiger Klein, Flavio Maina, Francis A. Barr

Publikováno v: Journal of Cell Biology
Journal of Cell Biology, Rockefeller University Press, 2005, 171, pp.337-348
Journal of Cell Biology, 2005, 171, pp.337-348
The Journal of Cell Biology

Hepatocyte growth factor (HGF)/Met signaling controls cell migration, growth and differentiation in several embryonic organs and is implicated in human cancer. The physiologic mechanisms that attenuate Met signaling are not well understood. Here we r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a955554a071a4acecb71fed20ec0408
https://hal.archives-ouvertes.fr/hal-00118502

Zobrazit plný text záznamu

RINGO efficiently triggers meiosis resumption in mouse oocytes and induces cell cycle arrest in embryos

Autor: Marie-Hélène Verlhac, Angel R. Nebreda, Ingvar Ferby, Marie-Emilie Terret

Publikováno v: Biology of the Cell
Biology of the Cell, 2001, 93 (1-2), pp.89-97
Biology of the Cell, Wiley, 2001, 93 (1-2), pp.89-97

International audience; RINGO was identified as a Cdc2-binding and activating protein which is necessary and sufficient to trigger G2/M progression in Xenopus oocytes. We have investigated whether the function of RINGO is conserved in mouse oocytes.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c38d039bd06dfe52da055285abc11567
https://hal.science/hal-02156014

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání