Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Ingunn M Stromnes"'
Autor:
Meagan R. Rollins, Jackson F. Raynor, Ebony A. Miller, Jonah Z. Butler, Ellen J. Spartz, Walker S. Lahr, Yun You, Adam L. Burrack, Branden S. Moriarity, Beau R. Webber, Ingunn M. Stromnes
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
The currently available transgenic T cell receptor (TCR) models represent high affinity antigen-TCR interactions. Authors here present an alternative approach to target an exogenous TCR into the physiological Trac locus in the germline of mice, which
Externí odkaz:
https://doaj.org/article/f686ccd3ae77471d8e50f4e9b637e5d1
Autor:
Michael T. Patterson, Adam L. Burrack, Yingzheng Xu, Grant H. Hickok, Zoe C. Schmiechen, Samuel Becker, Eduardo Cruz-Hinojoza, Patricia R. Schrank, Ainsley E. Kennedy, Maria M. Firulyova, Ebony A. Miller, Konstantin Zaitsev, Jesse W. Williams, Ingunn M. Stromnes
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112732- (2023)
Summary: Pancreatic ductal adenocarcinoma (PDA) orchestrates a suppressive tumor microenvironment that fosters immunotherapy resistance. Tumor-associated macrophages (TAMs) are the principal immune cell infiltrating PDA and are heterogeneous. Here, b
Externí odkaz:
https://doaj.org/article/9c8f1bd7911f4300864de0884a707a9f
Autor:
Adam L. Burrack, Zoe C. Schmiechen, Michael T. Patterson, Ebony A. Miller, Ellen J. Spartz, Meagan R. Rollins, Jackson F. Raynor, Jason S. Mitchell, Tsuneyasu Kaisho, Brian T. Fife, Ingunn M. Stromnes
Publikováno v:
JCI Insight, Vol 7, Iss 7 (2022)
We investigate how myeloid subsets differentially shape immunity to pancreatic ductal adenocarcinoma (PDA). We show that tumor antigenicity sculpts myeloid cell composition and functionality. Antigenicity promotes accumulation of type 1 dendritic cel
Externí odkaz:
https://doaj.org/article/78e01ca8e9fd4f30a7edc6e8a733121d
Autor:
Zoe C. Schmiechen, Ingunn M. Stromnes
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy with an overall 5-year survival rate of 10%. Disease lethality is due to late diagnosis, early metastasis and resistance to therapy, including immunotherapy. PDA creates a robust fibroinfl
Externí odkaz:
https://doaj.org/article/13b01b6e8b1c4ac3b570588c7b5e56b8
Autor:
Adam L. Burrack, Ellen J. Spartz, Meagan R. Rollins, Ebony A. Miller, Maria Firulyova, Eduardo Cruz, Michael F. Goldberg, Iris X. Wang, Hezkiel Nanda, Steven Shen, Konstantin Zaitsev, Ingunn M. Stromnes
Publikováno v:
Cancer Immunology, Immunotherapy. 72:1461-1478
Pancreatic ductal adenocarcinoma (PDA) is a lethal and metastatic malignancy resistant to therapy. Elucidating how pancreatic tumor-specific T cells differentiate and are maintained in vivo could inform novel therapeutic avenues to promote T cell ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a800b3a2978443d4dca76a444b603707
https://doi.org/10.1007/s00262-022-03338-7
https://doi.org/10.1007/s00262-022-03338-7
Autor:
Adam L. Burrack, Ellen J. Spartz, Jackson F. Raynor, Iris Wang, Margaret Olson, Ingunn M. Stromnes
Publikováno v:
Cell Reports, Vol 28, Iss 8, Pp 2140-2155.e6 (2019)
Summary: Pancreatic ductal adenocarcinoma (PDA) is a lethal cancer resistant to immunotherapy. We create a PDA mouse model and show that neoantigen expression is required for intratumoral T cell accumulation and response to immune checkpoint blockade
Externí odkaz:
https://doaj.org/article/432579c464ba4028af08cb056171821b
Autor:
Philip D. Greenberg, Raphael Gottardo, Charles W. Drescher, Ingunn M. Stromnes, Christopher B. Morse, Shannon K. Oda, Nicolas M. Garcia, Madison G. Burnett, Edison Y. Chiu, Breanna M. Bates, Valentin Voillet, Kristin G. Anderson
Figure S1: MSLN-specific engineered CD8 T cells induce cell death in HGSOC cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd28b9c0a947ea42642ccd5dc082597
https://doi.org/10.1158/2326-6066.22543438
https://doi.org/10.1158/2326-6066.22543438
Autor:
Sunil R. Hingorani, Philip D. Greenberg, Robert H. Pierce, Ellen J. Spartz, Jackson F. Raynor, J. Scott Brockenbrough, Cheryl Black, Patrick Bonson, Ayaka Hulbert, Adam L. Burrack, Ingunn M. Stromnes
Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy resistant to therapies, including immune-checkpoint blockade. We investigated two distinct strategies to modulate tumor-associated macrophages (TAM) to enhance cellular therapy targeting m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::090cc78bd1afb4f777552df268a76f6b
https://doi.org/10.1158/2326-6066.c.6549967.v1
https://doi.org/10.1158/2326-6066.c.6549967.v1
Autor:
Sunil R. Hingorani, Philip D. Greenberg, Robert H. Pierce, Ellen J. Spartz, Jackson F. Raynor, J. Scott Brockenbrough, Cheryl Black, Patrick Bonson, Ayaka Hulbert, Adam L. Burrack, Ingunn M. Stromnes
Supplementary Figures 1-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3889d98b8d31697f6a7b46d07e3a0c8
https://doi.org/10.1158/2326-6066.22542532
https://doi.org/10.1158/2326-6066.22542532
Autor:
Philip D. Greenberg, Raphael Gottardo, Charles W. Drescher, Ingunn M. Stromnes, Christopher B. Morse, Shannon K. Oda, Nicolas M. Garcia, Madison G. Burnett, Edison Y. Chiu, Breanna M. Bates, Valentin Voillet, Kristin G. Anderson
Figure Legends for Supplemental Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::975efb2816191d40d7b2661b26c8ea6e
https://doi.org/10.1158/2326-6066.22543414.v1
https://doi.org/10.1158/2326-6066.22543414.v1