Sequence Matters: Primary COVID-19 Vaccination after Infection Elicits Similar Anti-spike Antibody Levels, but Stronger Antibody Dependent Cell-mediated Cytotoxicity than Breakthrough Infection.

Autor: Holder KA; Immunology and Infectious Diseases Program, Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada., Ings DP; Immunology and Infectious Diseases Program, Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada., Fifield KE; Immunology and Infectious Diseases Program, Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada., Barnes DA; Immunology and Infectious Diseases Program, Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada., Barnable KA; Immunology and Infectious Diseases Program, Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada., Harnum DOA; Newfoundland and Labrador Health Services, St. John's, NL, Canada., Russell RS; Immunology and Infectious Diseases Program, Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada., Grant MD; Immunology and Infectious Diseases Program, Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada.

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2024 Oct 15; Vol. 213 (8), pp. 1105-1114.

Combined anti-S1 and anti-S2 antibodies from hybrid immunity elicit potent cross-variant ADCC against SARS-CoV-2.

Autor: Grant MD; Immunology and Infectious Diseases Program, Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland, Canada., Bentley K; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom., Fielding CA; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom., Hatfield KM; Immunology and Infectious Diseases Program, Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland, Canada., Ings DP; Immunology and Infectious Diseases Program, Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland, Canada., Harnum D; Eastern Health Regional Health Authority, St. John's, Newfoundland, Canada., Wang EC; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom., Stanton RJ; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom., Holder KA; Immunology and Infectious Diseases Program, Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland, Canada.

Publikováno v: JCI insight [JCI Insight] 2023 Aug 08; Vol. 8 (15). Date of Electronic Publication: 2023 Aug 08.

Moderate to severe SARS-CoV-2 infection primes vaccine-induced immunity more effectively than asymptomatic or mild infection.

Autor: Holder KA; Immunology and Infectious Diseases Program, Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada. kayla.holder@mun.ca., Ings DP; Immunology and Infectious Diseases Program, Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada., Harnum DOA; Eastern Health Regional Health Authority, St. John's, NL, Canada., Russell RS; Immunology and Infectious Diseases Program, Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada., Grant MD; Immunology and Infectious Diseases Program, Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada. mgrant@mun.ca.

Publikováno v: NPJ vaccines [NPJ Vaccines] 2022 Oct 21; Vol. 7 (1), pp. 122. Date of Electronic Publication: 2022 Oct 21.

Nanoparticle Uptake in a Spontaneous and Immunocompetent Woodchuck Liver Cancer Model.

Autor: Liu LY; Soham and Shaila Ajmera Family Transplant Centre, Toronto General Research Institute, University Health Network, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4.; Department of Immunology, University of Toronto, 1 King's College Circle, Medical Sciences Building, Room 6271, Toronto, Ontario, Canada M5S 1A8., Ma XZ; Soham and Shaila Ajmera Family Transplant Centre, Toronto General Research Institute, University Health Network, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4., Ouyang B; Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, Rosebrugh Building, Room 407, Toronto, Ontario, Canada M5S 3G9., Ings DP; Molecular Virology and Hepatology Research Group, Faculty of Medicine, Health Sciences Centre, Memorial University, 300 Prince Philip Drive, St. John's, Newfoundland, Canada A1B 3V6., Marwah S; Soham and Shaila Ajmera Family Transplant Centre, Toronto General Research Institute, University Health Network, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4., Liu J; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Room 230, Toronto, Ontario, Canada M5S 3E1., Chen AY; Molecular Virology and Hepatology Research Group, Faculty of Medicine, Health Sciences Centre, Memorial University, 300 Prince Philip Drive, St. John's, Newfoundland, Canada A1B 3V6., Gupta R; Soham and Shaila Ajmera Family Transplant Centre, Toronto General Research Institute, University Health Network, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4., Manuel J; Soham and Shaila Ajmera Family Transplant Centre, Toronto General Research Institute, University Health Network, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4., Chen XC; Soham and Shaila Ajmera Family Transplant Centre, Toronto General Research Institute, University Health Network, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4., Gage BK; Soham and Shaila Ajmera Family Transplant Centre, Toronto General Research Institute, University Health Network, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4.; McEwen Stem Cell Institute, University Health Network, Toronto, Ontario, Canada M5G 1L7., Cirlan I; Princess Margaret Genomics Centre, University Health Network, Toronto, Ontario, Canada M5G 1L7., Khuu N; Princess Margaret Genomics Centre, University Health Network, Toronto, Ontario, Canada M5G 1L7., Chung S; Soham and Shaila Ajmera Family Transplant Centre, Toronto General Research Institute, University Health Network, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4.; Department of Immunology, University of Toronto, 1 King's College Circle, Medical Sciences Building, Room 6271, Toronto, Ontario, Canada M5S 1A8., Camat D; Soham and Shaila Ajmera Family Transplant Centre, Toronto General Research Institute, University Health Network, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4.; Department of Immunology, University of Toronto, 1 King's College Circle, Medical Sciences Building, Room 6271, Toronto, Ontario, Canada M5S 1A8., Cheng M; Soham and Shaila Ajmera Family Transplant Centre, Toronto General Research Institute, University Health Network, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4.; Luna Nanotech, Toronto, Ontario, Canada M5G 1Y8., Sekhon M; Soham and Shaila Ajmera Family Transplant Centre, Toronto General Research Institute, University Health Network, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4., Zagorovsky K; Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, Rosebrugh Building, Room 407, Toronto, Ontario, Canada M5S 3G9.; Luna Nanotech, Toronto, Ontario, Canada M5G 1Y8., Abdou Mohamed MA; Luna Nanotech, Toronto, Ontario, Canada M5G 1Y8.; Botany and Microbiology Department, Faculty of Science, Zagazig University, Zagazig, Egypt 44519., Thoeni C; Soham and Shaila Ajmera Family Transplant Centre, Toronto General Research Institute, University Health Network, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4., Atif J; Soham and Shaila Ajmera Family Transplant Centre, Toronto General Research Institute, University Health Network, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4.; Department of Immunology, University of Toronto, 1 King's College Circle, Medical Sciences Building, Room 6271, Toronto, Ontario, Canada M5S 1A8., Echeverri J; Soham and Shaila Ajmera Family Transplant Centre, Toronto General Research Institute, University Health Network, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4., Kollmann D; Soham and Shaila Ajmera Family Transplant Centre, Toronto General Research Institute, University Health Network, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4., Fischer S; Soham and Shaila Ajmera Family Transplant Centre, Toronto General Research Institute, University Health Network, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4.; Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Medical Sciences Building, Room 6271, Toronto, Ontario, Canada M5S 1A8., Bader GD; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Room 230, Toronto, Ontario, Canada M5S 3E1., Chan WCW; Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, Rosebrugh Building, Room 407, Toronto, Ontario, Canada M5S 3G9.; Department of Materials Science and Engineering, University of Toronto, 160 College Street, Room 450, Toronto, Ontario, Canada M5S 3E1., Michalak TI; Molecular Virology and Hepatology Research Group, Faculty of Medicine, Health Sciences Centre, Memorial University, 300 Prince Philip Drive, St. John's, Newfoundland, Canada A1B 3V6., McGilvray ID; Soham and Shaila Ajmera Family Transplant Centre, Toronto General Research Institute, University Health Network, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4., MacParland SA; Soham and Shaila Ajmera Family Transplant Centre, Toronto General Research Institute, University Health Network, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4.; Department of Immunology, University of Toronto, 1 King's College Circle, Medical Sciences Building, Room 6271, Toronto, Ontario, Canada M5S 1A8.; Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Medical Sciences Building, Room 6271, Toronto, Ontario, Canada M5S 1A8.

Publikováno v: ACS nano [ACS Nano] 2020 Apr 28; Vol. 14 (4), pp. 4698-4715. Date of Electronic Publication: 2020 Apr 14.