Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Ingrid Velter"'
Autor:
José Manuel Bartolomé-Nebreda, Adriana Ingrid Velter, Peter Jacobus Johannes Antonius Buijnsters, Andrés A. Trabanco
Publikováno v:
Expert Opinion on Therapeutic Patents. 31:1117-1154
Introduction: O-GlcNAcylation is a highly abundant post-translational modification of multiple proteins, including the microtubule-binding protein tau, governed by just two enzymes’ concerted actio...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ee8ef238f0aa8391ae62a82b47711df
https://doi.org/10.1080/13543776.2021.1947242
https://doi.org/10.1080/13543776.2021.1947242
Autor:
Frans A. F. Van den Keybus, Peter Jacobus Johannes Antonius Buijnsters, Andrés A. Trabanco, Marijke Somers, Marieke Lamers, Gary Tresadern, Greet Vanhoof, Yves Emiel Maria Van Roosbroeck, Gregor James Macdonald, Ingrid Velter, Philip Leonard
Publikováno v:
Journal of Medicinal Chemistry. 63:12887-12910
We describe the hit-to-lead exploration of a [1,2,4]triazolo[1,5-a]pyrimidine phosphodiesterase 2A (PDE2A) inhibitor arising from high-throughput screening. X-ray crystallography enabled structure-guided design, leading to the identification of prefe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e154a70a8fb0c9559794b8e1758a37f4
https://doi.org/10.1021/acs.jmedchem.0c01272
https://doi.org/10.1021/acs.jmedchem.0c01272
Autor:
Frederik J. Rombouts, Lento William, Ingrid Velter, Ann Vos, Aldo Peschiulli, Reuillon Tristan, Maria Dominguez Blanco, Matthieu Jouffroy, Lisa McQueen, Helena Steyvers, Mariette Bekkers, Cristina Altrocchi, Beth Pietrak, Seong Joo Koo, Lawrence Szewczuk, David Walker, Kathryn Packman, Ruud Bueters, Petra Vinken, Amy Johnson, Ricardo Attar, Ulrike Philippar
Publikováno v:
Cancer Research. 82:2133-2133
Appropriate control of cell death is a fundamental biological process which is frequently dysregulated during tumor development and therapeutic resistance. Apoptosis is a form of regulated cell death initiated by either the extracellular environment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d26c71d6d913e202af7c340f376b66d7
https://doi.org/10.1158/1538-7445.am2022-2133
https://doi.org/10.1158/1538-7445.am2022-2133
Autor:
Gary, Tresadern, Ingrid, Velter, Andrés A, Trabanco, Frans, Van den Keybus, Gregor J, Macdonald, Marijke V F, Somers, Greet, Vanhoof, Philip M, Leonard, Marieke B A C, Lamers, Yves E M, Van Roosbroeck, Peter J J A, Buijnsters
Publikováno v:
Journal of medicinal chemistry. 63(21)
We describe the hit-to-lead exploration of a [1,2,4]triazolo[1,5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ed7a60164fecaf12ba4b19c9cac0666b
https://pubmed.ncbi.nlm.nih.gov/33105987
https://pubmed.ncbi.nlm.nih.gov/33105987
Autor:
Garrett Berlond Minne, Michel Surkyn, Harrie J.M. Gijsen, Francois Paul Bischoff, Nigel Austin, Marc Mercken, Didier Berthelot, Chiara Zavattaro, Ishtiyaque Ahmad, Gregor James Macdonald, Adriana Ingrid Velter, Michel Anna Jozef De Cleyn, Deborah Dhuyvetter, Sven Franciscus Anna Van Brandt, Serge Maria Aloysius Pieters, Yves Emiel Maria Van Roosbroeck, Swapan Kumar Samanta, Herman Borghys
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(14)
The discovery, design and synthesis of a new series of GSMs is described. The classical imidazole heterocycle has been replaced by a cyano group attached to an indole nucleus. The exploration of this series has led to compound 26-S which combined hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d9f458af2fb6e368fbdd2185f1f9926
https://pubmed.ncbi.nlm.nih.gov/31122869
https://pubmed.ncbi.nlm.nih.gov/31122869
Autor:
Ingrid Velter1 (AUTHOR), Barbara La Ferla1 (AUTHOR), Francesco Nicotra1 (AUTHOR) francesco.nicotra@unimib.it
Publikováno v:
Journal of Carbohydrate Chemistry. Mar2006, Vol. 25 Issue 2/3, p97-138. 42p. 19 Diagrams.
Autor:
Adam Arany, Jörg K. Wegner, Jorge Vialard, Vladimir Chupakhin, Marvin Steijaert, Anne E. Carpenter, Shantanu Singh, Peter Jacobus Johannes Antonius Buijnsters, Yves Moreau, Jaak Simm, Emmanuel Gustin, Ingrid Velter, Roel Wuyts, Sepp Hochreiter, A. Vapirev, Yolanda T. Chong, Hugo Ceulemans, Günter Klambauer
In both academia and the pharmaceutical industry, large-scale assays for drug discovery are expensive and often impractical, particularly for the increasingly important physiologically relevant model systems that require primary cells, organoids, who
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afdc9b02e29c077539f5f8d0bd2c0b57
https://lirias.kuleuven.be/handle/123456789/628737
https://lirias.kuleuven.be/handle/123456789/628737
Autor:
Jorge Vialard, Vladimir Chupakhin, Yves Moreau, Günter Klambauer, Shantanu Singh, Marvin Steijaert, Adam Arany, Sepp Hochreiter, Anne E. Carpenter, Hugo Ceulemans, Roel Wuyts, Emmanuel Gustin, Jörg K. Wegner, Peter Jacobus Johannes Antonius Buijnsters, A. Vapirev, Ingrid Velter, Jaak Simm, Yolanda T. Chong
We repurpose a High-Throughput (cell) Imaging (HTI) screen of a glucocorticoid receptor assay to predict target protein activity in multiple other seemingly unrelated assays. In two ongoing drug discovery projects, our repurposing approach increased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0059d469db8ccdab4e892970cfab25d3
Autor:
Brian Lord, Jason C. Rech, Brian Scott, Kirsten L. Morton, Nicholas I. Carruthers, Victor Contreras, Natalie A. Hawryluk, Qi Wang, Xiaohui Jiang, Francois Paul Bischoff, Michael A. Letavic, Alan D. Wickenden, Pascal Bonaventure, Hong Ao, Serge Maria Aloysius Pieters, Zachary S. Sales, Anindya Bhattacharya, Adriana Ingrid Velter
Publikováno v:
ACS Medicinal Chemistry Letters. 4:419-422
The synthesis and preclinical characterization of two novel, brain penetrating P2X7 compounds will be described. Both compounds are shown to be high potency P2X7 antagonists in human, rat, and mouse cell lines and both were shown to have high brain c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c778658858962a1ac276dc8d4cd5e98
https://doi.org/10.1021/ml400040v
https://doi.org/10.1021/ml400040v
Autor:
Gilles Marcou, Barbara La Ferla, Francesco Nicotra, Laura Belvisi, Anna Bernardi, Ingrid Velter, Črtomir Podlipnik
Publikováno v:
Carbohydrate Research. 342:1651-1660
C-Galactosides have been used as scaffolds to design a library of non-hydrolysable inhibitors of cholera toxin (CT). Test elements from the library were synthesized and found to inhibit CT binding to an asialofetuin-coated SPR chip with micromolar af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11944b10026af52e510c18eb93b71493
https://doi.org/10.1016/j.carres.2007.06.006
https://doi.org/10.1016/j.carres.2007.06.006