Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Ingrid Tessmer"'
Autor:
Ingrid Tessmer
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5131 (2024)
Given life’s dependence on genome maintenance, unsurprisingly, investigations of the molecular processes involved in protecting the genome or, failing this, repairing damages to and alterations introduced into genetic material are at the forefront
Externí odkaz:
https://doaj.org/article/d37489f913334ebebfc685405ccd6145
Autor:
Ingrid Tessmer, Geoffrey P. Margison
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 463 (2023)
DNA alkyltransferase and alkyltransferase-like family proteins are responsible for the repair of highly mutagenic and cytotoxic O6-alkylguanine and O4-alkylthymine bases in DNA. Their mechanism involves binding to the damaged DNA and flipping the bas
Externí odkaz:
https://doaj.org/article/7276bb10367f437495944d6eb6db758e
Publikováno v:
FEBS Open Bio, Vol 12, Iss 3, Pp 649-663 (2022)
The initiation of Okazaki fragment synthesis during cellular DNA replication is a crucial step for lagging strand synthesis, which is carried out by the primase function of DNA polymerase α‐primase (Pol‐prim). Since cellular replication protein
Externí odkaz:
https://doaj.org/article/a5ba71a7eddb4c6991bc2f323fa2b14b
Autor:
Disha Mohan Bangalore, Ingrid Tessmer
Publikováno v:
AIMS Biophysics, Vol 5, Iss 3, Pp 194-216 (2018)
Protein-DNA interactions are pivotal for many essential biological processes. Atomic force microscopy (AFM) imaging of protein-DNA systems involved in DNA target site search, identification, and processing by proteins has contributed invaluable infor
Externí odkaz:
https://doaj.org/article/952255d46b1e47ca8125066f7e72d0ff
Autor:
Huaying Zhao, Rodolfo Ghirlando, Carlos Alfonso, Fumio Arisaka, Ilan Attali, David L Bain, Marina M Bakhtina, Donald F Becker, Gregory J Bedwell, Ahmet Bekdemir, Tabot M D Besong, Catherine Birck, Chad A Brautigam, William Brennerman, Olwyn Byron, Agnieszka Bzowska, Jonathan B Chaires, Catherine T Chaton, Helmut Cölfen, Keith D Connaghan, Kimberly A Crowley, Ute Curth, Tina Daviter, William L Dean, Ana I Díez, Christine Ebel, Debra M Eckert, Leslie E Eisele, Edward Eisenstein, Patrick England, Carlos Escalante, Jeffrey A Fagan, Robert Fairman, Ron M Finn, Wolfgang Fischle, José García de la Torre, Jayesh Gor, Henning Gustafsson, Damien Hall, Stephen E Harding, José G Hernández Cifre, Andrew B Herr, Elizabeth E Howell, Richard S Isaac, Shu-Chuan Jao, Davis Jose, Soon-Jong Kim, Bashkim Kokona, Jack A Kornblatt, Dalibor Kosek, Elena Krayukhina, Daniel Krzizike, Eric A Kusznir, Hyewon Kwon, Adam Larson, Thomas M Laue, Aline Le Roy, Andrew P Leech, Hauke Lilie, Karolin Luger, Juan R Luque-Ortega, Jia Ma, Carrie A May, Ernest L Maynard, Anna Modrak-Wojcik, Yee-Foong Mok, Norbert Mücke, Luitgard Nagel-Steger, Geeta J Narlikar, Masanori Noda, Amanda Nourse, Tomas Obsil, Chad K Park, Jin-Ku Park, Peter D Pawelek, Erby E Perdue, Stephen J Perkins, Matthew A Perugini, Craig L Peterson, Martin G Peverelli, Grzegorz Piszczek, Gali Prag, Peter E Prevelige, Bertrand D E Raynal, Lenka Rezabkova, Klaus Richter, Alison E Ringel, Rose Rosenberg, Arthur J Rowe, Arne C Rufer, David J Scott, Javier G Seravalli, Alexandra S Solovyova, Renjie Song, David Staunton, Caitlin Stoddard, Katherine Stott, Holger M Strauss, Werner W Streicher, John P Sumida, Sarah G Swygert, Roman H Szczepanowski, Ingrid Tessmer, Ronald T Toth, Ashutosh Tripathy, Susumu Uchiyama, Stephan F W Uebel, Satoru Unzai, Anna Vitlin Gruber, Peter H von Hippel, Christine Wandrey, Szu-Huan Wang, Steven E Weitzel, Beata Wielgus-Kutrowska, Cynthia Wolberger, Martin Wolff, Edward Wright, Yu-Sung Wu, Jacinta M Wubben, Peter Schuck
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126420 (2015)
Analytical ultracentrifugation (AUC) is a first principles based method to determine absolute sedimentation coefficients and buoyant molar masses of macromolecules and their complexes, reporting on their size and shape in free solution. The purpose o
Externí odkaz:
https://doaj.org/article/3bd91e8f42734f39965350067490e003
Autor:
Disha M Bangalore, Ingrid Tessmer
Publikováno v:
Nucleic Acids Research. 50:10385-10398
The base excision repair (BER) glycosylase hOGG1 (human oxoguanine glycosylase 1) is responsible for repairing oxidative lesions in the genome, in particular oxidised guanine bases (oxoG). In addition, a role of hOGG1 in transcription regulation by r
Autor:
Sarah Kono, Aafke van den Berg, Marco Simonetta, Ann Mukhortava, Elspeth F. Garman, Ingrid Tessmer
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Significance We directly visualize DNA translocation and lesion recognition by the O 6 -alkylguanine DNA alkyltransferase (AGT). Our data show bidirectional movement of AGT monomers and clusters on undamaged DNA that depended on Zn 2+ occupancy of AG
Publikováno v:
Proc Natl Acad Sci U S A
Alkylation of guanine bases in DNA is detrimental to cells due to its high mutagenic and cytotoxic potential and is repaired by the alkyltransferase AGT. Additionally, alkyltransferase-like proteins (ATLs), which are structurally similar to AGTs, hav
Autor:
Angela Borst, Felicia Scheffel, Nichodemus O. Onwubiko, Suraya A. Diaz, Heinz-Peter Nasheuer, Katharina Passkowski, Ingrid Tessmer
Publikováno v:
Nucleic Acids Research
DNA replication is a central process in all living organisms. Polyomavirus DNA replication serves as a model system for eukaryotic DNA replication and has considerably contributed to our understanding of basic replication mechanisms. However, the det
Publikováno v:
FEBS open bio. 12(3)
The initiation of Okazaki fragment synthesis during cellular DNA replication is a crucial step for lagging strand synthesis, which is carried out by the primase function of DNA polymerase ¿-primase (Pol-prim). Since cellular replication protein A (R