Výsledky vyhledávání - "Ingrid Sjögren"

Evaluation of Cell Proliferation in Rat Mammary Glands Is Not Predictive of the Carcinogenic Potential of Insulin In Vivo

Autor: Anne-Marie Mølck, Ingrid Sjögren, Jette Nowak, Vivi F. H. Jensen, Inger Thorup, Peter R. Brinck

Publikováno v: International Journal of Toxicology. 39:560-576

For nonclinical safety-assessment of insulin analogues in vivo, mitogenic effects are compared to that of human insulin. Besides histopathologic evaluation, this usually includes assessment of cell proliferation (CP) in mammary glands. Insulin analog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a354a664c636addf55ba41b1319f3c0
https://doi.org/10.1177/1091581820941776

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The Effect of Diet-induced Obesity on Toxicological Parameters in the Polygenic Sprague-Dawley Rat Model

Autor: Johannes Josef Fels, Henrik Søeborg, Inger Thorup, Mikala Skydsgaard, Lærke W. Andersen, Hanne Offenberg, Kevin A. Keane, Charlotte M. Dalsgaard, Ingrid Sjögren, Jennifer M. Rojas, Line Olrik Berthelsen, Jette Nowak, Florian Bolze, Jes Tovborg Jensen, Majken Dalgaard

Publikováno v: Toxicologic Pathology. 46:777-798

The obese rodent serves as an indispensable tool for proof-of-concept efficacy and mode-of-action pharmacology studies. Yet the utility of this disease model as an adjunct to the conventional healthy animal in the nonclinical safety evaluation of ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::720b22f18b55257c12209b4651c6fd5d
https://doi.org/10.1177/0192623318803557

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Evaluation of the PhysioTel™ Digital M11 cardiovascular telemetry implant in socially housed cynomolgus monkeys up to 16weeks after surgery

Autor: Olivier Meyer, Ingrid Sjögren, Aileen Milne, Anders B. Lassen, Warren Harvey, Nils Dragsted, Rastislav Bator, Julie M. Larsen, Alys Bradley, Ninette K. Andersen

Publikováno v: Journal of pharmacological and toxicological methods. 87

Introduction The novel PhysioTel™ Digital M11 telemetry implant was evaluated in socially housed monkeys with respect to both safety pharmacological cardiovascular (arterial blood pressure (BP), heart rate (HR) and electrocardiogram (ECG)) and toxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb867fb6a999b4e7db30c1c3b778f490
https://pubmed.ncbi.nlm.nih.gov/28416413

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Generalized Cellular Hypertrophy is Induced by a Dual-Acting PPAR Agonist in Rat Urinary Bladder Urothelium In Vivo

Autor: Torben S. Guldberg, Peter R. Brinck, Inger Thorup, Anne Charlotte Hegelund, Marianne B. Jensen, Ulla K. Thinggaard, Ingrid Sjögren, Henriette S. Nielsen, Lars Fogh Iversen, Martin B. Oleksiewicz, Hanne V. Andersen, Lis Jørgensen

Publikováno v: Toxicologic Pathology. 33:552-560

Some developmental dual-acting PPARα/γ agonists, such as ragaglitazar, have shown carcinogenic effects in the rodent urinary bladder urothelium after months-years of dosing. We examined early (precancerous) changes in the bladder urothelium of rats

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7c61986d6c55074d8bf062939d91022
https://doi.org/10.1080/01926230500214657

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GLP-1 Receptor Agonists and the Thyroid: C-Cell Effects in Mice Are Mediated via the GLP-1 Receptor and not Associated with RET Activation

Autor: Sushil K. Vundavalli, Ingrid Sjögren, Carsten F. Gotfredsen, Lotte Bjerre Knudsen, Anne Sietske de Boer, Lene Nonboe Andersen, Lars Wichmann Madsen, Katia Manova, Anne Marie Moelck, Andrew M. Pilling, Jeffrey A. Knauf, Søren Andersen, Niels C. Berg Nyborg, James A. Fagin, Afsar Barlas

Liraglutide and exenatide are glucagon-like peptide receptor (GLP-1R) agonists used in the treatment of type 2 diabetes. Both molecules have been associated with the development of thyroid C-cell tumors after lifetime exposure in rodents. Previously,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f6a59e55953f28e3d3158813ed885e
https://europepmc.org/articles/PMC3281535/

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An alternative method for preparation of tissue sections from the rat mammary gland

Autor: Henning Hvid, Ingrid Sjögren, Henrik Jeldtoft Jensen, Martin B. Oleksiewicz, Inger Thorup

Publikováno v: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 63(4)

In toxicopathological studies of the rat mammary glands, the guidelines of the Registry of Industrial Toxicology and Animal Data (RITA) recommend transverse sections of the inguinal mammary gland. However, occasionally limited amounts of mammary glan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e865725c73ea33b196aa0f90693efd
https://pubmed.ncbi.nlm.nih.gov/20199854

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Liquid Growth Hormone: Preservatives and Buffers

Autor: Anne-Marie Kappelgaard, Torben Laursen, Anders Bojesen, Karsten Skydsgaard, Ingrid Sjögren

Publikováno v: Kappelgaard, A A, Bojesen, A, Skydsgaard, K, Sjögren, I & Laursen, T 2004, ' Liquid Growth Hormone: Preservatives and Buffers ', Hormone Research, vol. 62, no. Suppl.3, pp. 1197-16 .
Kappelgaard, A-M, Anders, B, Skydsgaard, K, Sjögren, I & Laursen, T 2004, ' Liquid growth hormone: preservatives and buffers ', Hormone Research, vol. 62, no. Suppl.3, pp. 98-103 . < http://www.ncbi.nlm.nih.gov/pubmed/15539807 >
Scopus-Elsevier

Growth hormone (GH) treatment is a successful medical therapy for children and adults with GH deficiency as well as for growth retardation due to chronic renal disease, Turner syndrome and in children born small for gestational age. For all of these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::886909121b15ff2804ffa661d747623e
https://pure.au.dk/portal/da/publications/liquid-growth-hormone-preservatives-and-buffers(1f93bef0-fd23-11da-bee9-02004c4f4f50).html

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