Immune activation correlates with and predicts CXCR4 co-receptor tropism switch in HIV-1 infection

Autor: Ingrid Schellens, Hugo A. Tempelman, Maria A. Papathanasopoulos, José A. M. Borghans, Annemarie M. J. Wensing, Neeltje A. Kootstra, M. Nijhuis, Dorien de Jong, Tholakele Mathe, Petra M. van Ham, Sigrid Otto, Pauline J. Schipper, Zita Kruize, Robert Moraba, Bridgette Janine Connell, Francois Venter, Kiki Tesselaar, Lucas E Hermans

Publikováno v: Scientific reports, 10(1):15866. Nature Publishing Group
Scientific Reports
Connell, B J, Hermans, L E, Wensing, A M J, Schellens, I, Schipper, P J, van Ham, P M, de Jong, D T C M, Otto, S, Mathe, T, Moraba, R, Borghans, J A M, Papathanasopoulos, M A, Kruize, Z, Venter, F W D, Kootstra, N A, Tempelman, H, Tesselaar, K & Nijhuis, M 2020, ' Immune activation correlates with and predicts CXCR4 co-receptor tropism switch in HIV-1 infection ', Scientific Reports, vol. 10, no. 1, 15866 . https://doi.org/10.1038/s41598-020-71699-z
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports, 10(1):15866. Nature Publishing Group

HIV-1 cell entry is mediated by binding to the CD4-receptor and chemokine co-receptors CCR5 (R5) or CXCR4 (X4). R5-tropic viruses are predominantly detected during early infection. A switch to X4-tropism often occurs during the course of infection. X

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https://pure.amc.nl/en/publications/immune-activation-correlates-with-and-predicts-cxcr4-coreceptor-tropism-switch-in-hiv1-infection(b10e0da7-a0ea-4b0d-853e-5221f69a365b).html