Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Ingrid Saba"'
Autor:
Jinghua Lu, François Van Laethem, Abhisek Bhattacharya, Marco Craveiro, Ingrid Saba, Jonathan Chu, Nicholas C. Love, Anastasia Tikhonova, Sergei Radaev, Xiaoping Sun, Annette Ko, Tomer Arnon, Eric Shifrut, Nir Friedman, Nan-Ping Weng, Alfred Singer, Peter D. Sun
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
For T cells, functional antigen receptors are selected in the thymus from a pre-selection repertoire by interaction with self MHCs. Here the authors show that specific, non-germline coded features located in the complementarity determining region 3 o
Externí odkaz:
https://doaj.org/article/2135b8948a994dbda344f75d21b684fb
Autor:
François Van Laethem, Ingrid Saba, Jinghua Lu, Abhisek Bhattacharya, Xuguang Tai, Terry I. Guinter, Britta Engelhardt, Amala Alag, Mirelle Rojano, Jennifer M. Ashe, Ken-ichi Hanada, James C. Yang, Peter D. Sun, Alfred Singer
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
MHC-independent αβTCRs (TCRs) recognize conformational epitopes on native self-proteins and arise in mice lacking both MHC and CD4/CD8 coreceptor proteins. Although naturally generated in the thymus, these TCRs resemble re-engineered therapeutic ch
Externí odkaz:
https://doaj.org/article/8782eccbbb154dcb86bc5b3f712336d7
Autor:
James D Phelan, Ingrid Saba, Hui Zeng, Christian Kosan, Malynda S Messer, H Andre Olsson, Jennifer Fraszczak, David A Hildeman, Bruce J Aronow, Tarik Möröy, H Leighton Grimes
Publikováno v:
PLoS Genetics, Vol 9, Iss 9, p e1003713 (2013)
Growth factor independent 1 (Gfi1) is a transcriptional repressor originally identified as a gene activated in T-cell leukemias induced by Moloney-murine-leukemia virus infection. Notch1 is a transmembrane receptor that is frequently mutated in human
Externí odkaz:
https://doaj.org/article/ecc354ee1fdc4214a1d727d92fc781bf
Prevascularized Tissue-Engineered Human Vaginal Mucosa: In Vitro Optimization and In Vivo Validation
Autor:
Todd Galbraith, Ingrid Saba, Stéphane Bolduc, Weronika Jakubowska, Stéphane Chabaud, François Berthod
Publikováno v:
Tissue Engineering Part A. 26:811-822
Tissue engineering offers novel therapies for vaginal reconstruction in patients with congenital vaginal agenesis such as Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome. This study aims to reconstruct a prevascularized tissue-engineered model of huma
Autor:
Asmaa Lachhab, Corinne Barat, Stéphane Bolduc, Ingrid Saba, Hazem Orabi, Michel J. Tremblay, Weronika Jakubowska, Stéphane Chabaud, Martin Pelletier, Maude Leclerc, Nolan Reyjon
Publikováno v:
Tissue engineering. Part C, Methods. 27(3)
The lack of appropriate experimental models often limits our ability to investigate the establishment of infections in specific tissues. To reproduce the structural and spatial organization of vaginal mucosae to study human immunodeficiency virus typ
Autor:
Terry I. Guinter, Mirelle Rojano, Britta Engelhardt, Ingrid Saba, James Chih-Hsin Yang, Abhisek Bhattacharya, Jinghua Lu, Ken-ichi Hanada, Amala Alag, Alfred Singer, François Van Laethem, Peter D. Sun, Jennifer M. Ashe, Xuguang Tai
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2020)
Van Laethem, François; Saba, Ingrid; Lu, Jinghua; Bhattacharya, Abhisek; Tai, Xuguang; Guinter, Terry I; Engelhardt, Britta; Alag, Amala; Rojano, Mirelle; Ashe, Jennifer M; Hanada, Ken-Ichi; Yang, James C; Sun, Peter D; Singer, Alfred (2020). Novel MHC-Independent αβTCRs Specific for CD48, CD102, and CD155 Self-Proteins and Their Selection in the Thymus. Frontiers in immunology, 11, p. 1216. Frontiers Research Foundation 10.3389/fimmu.2020.01216
Frontiers in Immunology, Vol 11 (2020)
Van Laethem, François; Saba, Ingrid; Lu, Jinghua; Bhattacharya, Abhisek; Tai, Xuguang; Guinter, Terry I; Engelhardt, Britta; Alag, Amala; Rojano, Mirelle; Ashe, Jennifer M; Hanada, Ken-Ichi; Yang, James C; Sun, Peter D; Singer, Alfred (2020). Novel MHC-Independent αβTCRs Specific for CD48, CD102, and CD155 Self-Proteins and Their Selection in the Thymus. Frontiers in immunology, 11, p. 1216. Frontiers Research Foundation 10.3389/fimmu.2020.01216
MHC-independent αβTCRs (TCRs) recognize conformational epitopes on native self-proteins and arise in mice lacking both MHC and CD4/CD8 coreceptor proteins. Although naturally generated in the thymus, these TCRs resemble re-engineered therapeutic ch
Autor:
Weronika, Jakubowska, Stéphane, Chabaud, Ingrid, Saba, Todd, Galbraith, François, Berthod, Stéphane, Bolduc
Publikováno v:
Tissue engineering. Part A. 26(13-14)
Tissue engineering offers novel therapies for vaginal reconstruction in patients with congenital vaginal agenesis such as Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome. This study aims to reconstruct a prevascularized tissue-engineered model of hum
Autor:
Abhisek Bhattacharya, Alfred Singer, Jinghua Lu, Ingrid Saba, Jonathan Chu, Peter D. Sun, François Van Laethem, Anastasia N. Tikhonova
Publikováno v:
J Immunol
During normal T cell development in the thymus, αβ TCRs signal immature thymocytes to differentiate into mature T cells by binding to peptide–MHC ligands together with CD4/CD8 coreceptors. Conversely, in MHC and CD4/CD8 coreceptor-deficient mice,
Publikováno v:
BioMed Research International
BioMed Research International, Vol 2018 (2018)
BioMed Research International, Vol 2018 (2018)
Twenty years ago, Dr. François A. Auger, the founder of the Laboratory of Experimental Organogenesis (LOEX), introduced the self-assembly technique. This innovative technique relies on the ability of dermal fibroblasts to produce and assemble their
Autor:
Ingrid Saba, Stéphane Chabaud, Clément Baratange, Sara Bouhout, Alexandre Rousseau, Stéphane Bolduc, Maude Leclerc, Brice Boiroux
Publikováno v:
Journal of Tissue Engineering and Regenerative Medicine. 11:3090-3099
Cells obtained from a patient's biopsy have to be expanded after extraction to produce autologous tissues, but standard cell culture conditions often limit their growth or lifespan and could induce early and inadequate cell differentiation. Moreover,