Výsledky vyhledávání - "Ingrid Påhlman"

A Novel Topical PPARγ Agonist Induces PPARγ Activity in Ulcerative Colitis Mucosa and Prevents and Reverses Inflammation in Induced Colitis Models

Autor: Jan P Mattson, Åsa V. Keita, Vassilia Theodorou, Ingrid Påhlman, Johan D. Söderholm, Sven Påhlman, Sofie Mohlin, Stéphanie Da Silva

Publikováno v: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases, Lippincott, Williams & Wilkins, 2018, 24 (4), pp.792-805. ⟨10.1093/ibd/izx079⟩

International audience; Background: Peroxisome proliferator-activated receptor-gamma (PPAR gamma) exerts anti-inflammatory effects and is therefore a potential target in ulcerative colitis (UC). A novel PPAR. agonist (AS002) developed for local actio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::035caee86726c54d7124a8adae61403c
https://doi.org/10.1093/ibd/izx079

Zobrazit plný text záznamu

Pharmacokinetics of Tolterodine, a Muscarinic Receptor Antagonist, in Mouse, Rat and Dog

Autor: Lena Palmér, Ingrid Påhlman, Sari Kankaanranta

Publikováno v: Arzneimittelforschung. 51:134-144

Tolterodine ((R)-N,N-diisopropyl- 3- (2- hydroxyl- 5- methylphenyl)- 3- henylpropanamine, CAS 124937-51-5) is an antimuscarinic agent developed specifically for the treatment of the overactive bladder. In this study, the pharmacokinetics of tolterodi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3d846f494c95a624fbf9e974da2f343b
https://doi.org/10.1055/s-0031-1300015

Zobrazit plný text záznamu

Oral baclofen reduces visceral pain-related pseudo-affective responses to colorectal distension in rats: Relation between plasma exposure and efficacy

Autor: Vicente Martínez, Håkan Larsson, Anna Novén, Erik Lindström, Ingrid Påhlman, Dorota Kakol-Palm, Anna Ravnefjord, Mikael Brusberg

Publikováno v: Scandinavian Journal of Gastroenterology. 46:652-662

We previously showed that activation of GABA(B) receptors by intravenous baclofen reduces pseudo-affective responses to colorectal distension in rats. Here we evaluate the potential clinical significance of these observations.Clinically relevant colo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bbc2076f0760a49233b74da2103aa8f
https://doi.org/10.3109/00365521.2011.560677

Zobrazit plný text záznamu

Occurrence and pharmacological characterization of four human tachykinin NK2 receptor variants

Autor: Chris Perrey, Susanna Engberg, Bengt von Mentzer, Adrian Moody, John Edward Norris Morten, Maria Lagerström-Fermér, Ingela Ahlstedt, Tomas Drmota, Ingrid Påhlman, John Craig Smith, Erik Lindström

Publikováno v: Biochemical Pharmacology. 76:476-481

Tachykinin NK(2) receptor antagonists are potentially beneficial in treating various disorders including irritable bowel syndrome, urinary incontinence, depression and anxiety. The current study evaluates the frequency of single nucleotide polymorphi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb412526d1bb0d81b808089af8c01b07
https://doi.org/10.1016/j.bcp.2008.06.003

Zobrazit plný text záznamu

Neurokinin 1 Receptor Antagonists: Correlation between in Vitro Receptor Interaction and in Vivo Efficacy

Autor: Bengt von Mentzer, Anna Uvebrant, Jennie de Verdier, Elin Kristensson, Ingrid Påhlman, Georges Vauquelin, Erik Lindström, Ingela Ahlstedt, Anna Novén, Rakel Martinsson

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 322:1286-1293

We compared the neurokinin 1 receptor (NK(1)R) antagonists aprepitant, CP-99994 [(2S,3S)-3-(2-methoxybenzylamino)-2-phenylpiperidine], and ZD6021 [3-cyano-N-((2S)-2-(3,4-dichlorophenyl)-4-[4-[2-(methyl-(S)-sulfinyl)phenyl]piperidino]butyl)-N-methyl]n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d050d83a2ebe99920ea2874760c6c8aa
https://doi.org/10.1124/jpet.107.124958

Zobrazit plný text záznamu

Molecular cloning, mutations and effects of NK1 receptor antagonists reveal the human-like pharmacology of gerbil NK1 receptors

Autor: Anders Johansson, Tomas Drmota, Ingela Ahlstedt, Ingrid Påhlman, Erik Lindström, Bengt von Mentzer, Agnes Leffler, Svensson Arne, Elin Kristensson, Susanna Engberg

Publikováno v: Biochemical Pharmacology. 73:259-269

The present study investigates the pharmacology of the cloned neurokinin 1 receptor from the gerbil (gNK 1 R), a species claimed to have human-like NK 1 R (hNK 1 R) pharmacology. The amino acid sequence of NK 1 R was cloned. The hNK 1 R, rat NK 1 R (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ead55fc1350dbe27b20fa03bd9cb82ec
https://doi.org/10.1016/j.bcp.2006.09.030

Zobrazit plný text záznamu

Inhibition of intestinal bile acid absorption improves cholestatic liver and bile duct injury in a mouse model of sclerosing cholangitis

Autor: Anna, Baghdasaryan, Claudia D, Fuchs, Christoph H, Österreicher, Ursula J, Lemberger, Emina, Halilbasic, Ingrid, Påhlman, Hans, Graffner, Elisabeth, Krones, Peter, Fickert, Annika, Wahlström, Marcus, Ståhlman, Gustav, Paumgartner, Hanns-Ulrich, Marschall, Michael, Trauner

Publikováno v: Journal of hepatology. 64(3)

Approximately 95% of bile acids (BAs) excreted into bile are reabsorbed in the gut and circulate back to the liver for further biliary secretion. Therefore, pharmacological inhibition of the ileal apical sodium-dependent BA transporter (ASBT/SLC10A2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fbe0f52da439664cd4831cfba5a936a4
https://pubmed.ncbi.nlm.nih.gov/26708144

Zobrazit plný text záznamu

Extensive Biliary Excretion of the Sulfasalazine Analogue, Susalimod, but Different Concentrations in the Bile Duct in Various Animal Species Correlating to Species-Specific Hepatobiliary Toxicity

Autor: Ingrid Påhlman, Marie-Louise Odell, Maria Wilén, Stig Andersson, Kjell Gunnarsson

Publikováno v: Pharmacology & Toxicology. 85:123-129

Studies on biliary concentrations of susalimod were conducted in rat, dog and monkey to clarify the interspecies differences observed in toxicology studies with respect to hepatobiliary toxicity after long-term administration of the compound. Dose-re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::695aa9407c98f0a9df7ea3030214db89
https://doi.org/10.1111/j.1600-0773.1999.tb00078.x

Zobrazit plný text záznamu

Serum protein binding of tolterodine and its major metabolites in humans and several animal species

Autor: Peter Gozzi, Ingrid Påhlman

Publikováno v: Biopharmaceutics & Drug Disposition. 20:91-99

The aim of this study was to determine in vitro protein binding of tolterodine and its 5-hydroxymethyl (5-HM) and N-dealkylated metabolites in serum from humans and several animal species at concentrations similar to those obtained in clinical and pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::629500f3a058644d5fed605f1804b7d5
https://doi.org/10.1002/(sici)1099-081x(199903)20:2<91::aid-bdd162>3.0.co

Zobrazit plný text záznamu

Efficient Biliary Excretion of Susalimod, Probably via the Bromosulphthalein Carrier, Studied in a Chronic Bile Fistula Model in Dogs

Autor: Staffan Bowald, Ingrid Påhlman, Maria Wilén

Publikováno v: Journal of Pharmacy and Pharmacology. 51:61-66

Susalimod is a structural analogue of sulphasalazine, known to be extensively excreted in the bile in various animal species and for inducing bile duct hyperplasia after long-term treatment of the dog with doses exceeding 25 mg kg−1. In this study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fc08c36390964518839d81c66f4c234
https://doi.org/10.1211/0022357991771962

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání