Výsledky vyhledávání - "Ingrid Oit-Wiscombe"

Akademický článek

Antioxidant Glutathione Analogues UPF1 and UPF17 Modulate the Expression of Enzymes Involved in the Pathophysiology of Chronic Obstructive Pulmonary Disease

Autor: Ingrid Oit-Wiscombe, Ursel Soomets, Alan Altraja

Publikováno v: Current Issues in Molecular Biology, Vol 46, Iss 3, Pp 2343-2354 (2024)

Increased oxidative stress (OS) and systemic inflammation are key players in the pathophysiology of chronic obstructive pulmonary disease (COPD). We aimed to clarify the effects of synthetic glutathione (GSH) analogue peptides UPF1 and UPF17 on the m

Externí odkaz: https://doaj.org/article/67b5681ba2cd425ba0c8d0a1ab1e4bf7

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Akademický článek

Pattern of Expression of Genes Involved in Systemic Inflammation and Glutathione Metabolism Reveals Exacerbation of COPD

Autor: Ingrid Oit-Wiscombe, László Virág, Kalle Kilk, Ursel Soomets, Alan Altraja

Publikováno v: Antioxidants, Vol 13, Iss 8, p 953 (2024)

To test the hypothesis that they serve as systemic biomarkers of chronic obstructive pulmonary disease (COPD), we profiled the mRNA expression of enzymes connected to systemic inflammation and GSH metabolism in peripheral blood mononuclear cells (PBM

Externí odkaz: https://doaj.org/article/6f43c269322544eab3e8bdeddd368d04

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Akademický článek

Increased DNA damage in progression of COPD: a response by poly(ADP-ribose) polymerase-1.

Autor: Ingrid Oit-Wiscombe, Laszlo Virag, Ursel Soomets, Alan Altraja

Publikováno v: PLoS ONE, Vol 8, Iss 7, p e70333 (2013)

Chronic oxidative stress (OS), a major mechanism of chronic obstructive pulmonary disease (COPD), may cause significant damage to DNA. Poly(ADP-ribose) polymerase (PARP)-1 is rapidly activated by OS-induced DNA lesions. However, the degree of DNA dam

Externí odkaz: https://doaj.org/article/37ffee5efbad4ec7b1fc5e0227de7332

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