Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Ingrid Marko"'
Autor:
Ricardo A. P. Pádua, Yizhi Sun, Ingrid Marko, Warintra Pitsawong, John B. Stiller, Renee Otten, Dorothee Kern
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
The protein tyrosine phosphatase SHP2 is a key regulator of cell cycle control. Here the authors combine NMR measurements and X-ray crystallography and show that wild-type SHP2 dynamically exchanges between a closed inactive conformation and an open
Externí odkaz:
https://doaj.org/article/77cc04b8724e47ce9663728a803fea11
Autor:
Warintra Pitsawong, Yizhi Sun, Renee Otten, Ricardo A.P. de Pádua, Ingrid Marko, John B. Stiller, Dorothee Kern
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications
Nature Communications
Protein tyrosine phosphatase SHP2 functions as a key regulator of cell cycle control, and activating mutations cause several cancers. Here, we dissect the energy landscape of wild-type SHP2 and the oncogenic mutation E76K. NMR spectroscopy and X-ray
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1161a3b3bde31ad4fd38f559a6cf5e6a
https://doi.org/10.1038/s41467-018-06814-w
https://doi.org/10.1038/s41467-018-06814-w