Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Ingrid M. Pilip"'
Autor:
Huub T. C. Kreuwel, Judith A. Biggs, David Lo, Eric G. Pamer, Linda A. Sherman, Ingrid M. Pilip
Publikováno v:
The Journal of Immunology. 167:1112-1117
Nonobese diabetic (NOD) mice develop spontaneous autoimmune diabetes that involves participation of both CD4+ and CD8+ T cells. Previous studies have demonstrated spontaneous reactivity to self-Ags within the CD4+ T cell compartment in this strain. W
Autor:
Eric G. Pamer, Roberto Mercado, Sujata Vijh, Kristen M. Kerksiek, Ingrid M. Pilip, S. Elise Allen
Publikováno v:
The Journal of Immunology. 165:6833-6839
The duration of infection and the quantity of Ag presented in vivo are commonly assumed to influence, if not determine, the magnitude of T cell responses. Although the cessation of in vivo T cell expansion coincides with bacterial clearance in mice i
Autor:
Eric G. Pamer, Ingrid M. Pilip, Natalie A. Marshall, Nancy Berliner, Richard Formica, John Greg Howe, Diane Krause, John E. Wagner, Jill Crouch, Dennis L. Cooper, Bruce R. Blazar, Stuart Seropian
Publikováno v:
Blood. 96:2814-2821
Epstein-Barr virus (EBV)–specific CD8 T lymphocytes are present at remarkably high frequencies in healthy EBV+individuals and provide protection from EBV-associated lymphoproliferative diseases. Allogeneic peripheral blood stem cell transplantation
Publikováno v:
Infection and Immunity. 67:1303-1309
Listeria monocytogenes is an intracellular bacterium that elicits complex cytotoxic T-lymphocyte (CTL) responses in infected mice. The responses of CTL populations that differ in antigen specificity range in magnitude from large, dominant responses t
Publikováno v:
The Journal of Immunology. 162:980-988
CD8+ T cells require perforin to mediate immunity against some, but not all, intracellular pathogens. Previous studies with H-2b MHC perforin gene knockout (PO) mice revealed both perforin-dependent and perforin-independent pathways of CD8+ T cell-me
Publikováno v:
The Journal of Experimental Medicine
Major histocompatibility complex (MHC) class Ib molecules have been implicated in CD8+ T cell–mediated defenses against intracellular bacterial infection, but the relative importance of MHC class Ib–restricted T cells in antimicrobial immunity is
Publikováno v:
The Journal of Immunology. 160:3971-3977
T lymphocytes eradicate and provide long-term immunity to infections caused by intracellular pathogens. The mechanisms that determine in vivo T cell response sizes are poorly understood. Although it is speculated that the relative processing efficien
Publikováno v:
Immunity. 8:353-362
Bacterial infections activate complex T cell populations that differ in size and antigen specificity. We used tetramerized MHC class I molecules complexed with Listeria monocytogenes–derived epitopes to characterize four distinct CD8+ T lymphocyte
Publikováno v:
Journal of Biological Chemistry. 272:19261-19268
Cytosolic antigen degradation is an initial step in the generation of major histocompatibility complex (MHC) class I-associated cytolytic T lymphocyte epitopes. IntracellularListeria monocytogenes secretes p60, a murein hydrolase, into the host cell
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 166(6)
Listeria monocytogenes is an intracellular bacterium that causes systemic infections after traversing the intestinal mucosa. Clearance of infection and long term protective immunity are mediated by L. monocytogenes-specific CD8 T lymphocytes. In this