Attention for sex in COVID-19 trials: a review of regulatory dossiers

Autor: Sieta T de Vries, Peter G M Mol, Harald Enzmann, Viktoriia Starokozhko, Ingrid M M Schellens, Leonoor Wijnans, Marco Cavaleri

Publikováno v: BMJ Global Health, Vol 7, Iss 3 (2022)

An under-representation of women and a lack of sex-specific analyses in COVID-19 trials has been suggested. However, the higher number of men than women who are severely affected by COVID-19 and the restricted information in scientific publications m

Externí odkaz: https://doaj.org/article/2a448a4269c14d4a8dd8d241447638df

Abundance of early functional HIV-specific CD8+ T cells does not predict AIDS-free survival time.

Autor: Ingrid M M Schellens, José A M Borghans, Christine A Jansen, Iris M De Cuyper, Ronald B Geskus, Debbie van Baarle, Frank Miedema

Publikováno v: PLoS ONE, Vol 3, Iss 7, p e2745 (2008)

BACKGROUND: T-cell immunity is thought to play an important role in controlling HIV infection, and is a main target for HIV vaccine development. HIV-specific central memory CD8(+) and CD4(+) T cells producing IFNgamma and IL-2 have been associated wi

Externí odkaz: https://doaj.org/article/0f969c0c61434a49a9fd3fbbd382f5f9

A Lower Viral Set Point but Little Immunological Impact After Early Treatment During Primary HIV Infection

Autor: Nening M. Nanlohy, Ingrid M. M. Schellens, Marlous L. Grijsen, Debbie van Baarle, Neeltje A. Kootstra, José A. M. Borghans, Hilde B. Spits, Jan M. Prins, Radjin Steingrover

Publikováno v: Viral immunology, 28(3), 134-144. Mary Ann Liebert Inc.

The Primo-SHM trial, a multicenter randomized trial comparing no treatment with 24 or 60 weeks of combination antiretroviral therapy (cART) during primary human immunodeficiency virus (HIV) infection (PHI), recently demonstrated that temporary early

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb7662a70439deaebd6e7c2c1fac26d3
https://doi.org/10.1089/vim.2014.0094

Influence of HIV Infection on Cytomegalovirus-Specific Immunity: T-Cell Responses to Pp65 and Ie1 before and after Haart May Refect Altered Cytomegalovirus Biology

Autor: Debbie van Baarle, Ingrid M. M. Schellens, Jolanda Scherrenburg

Publikováno v: Antiviral Therapy. 16:565-575

Background Data are inconclusive whether treatment with HAART induces functional recovery of HIV-specific T-cells. Since the introduction of HAART, a marked decrease of cytomegalovirus (CMV) disease – for which untreated HIV-infected individuals ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e65f55438aae8e0e82c8344a53ef747
https://doi.org/10.3851/imp1800

Rapid reconstitution of CD4 T cells and NK cells protects against CMV-reactivation after allogeneic stem cell transplantation

Autor: Ronald Jacobi, Sanne Spijkers, Dan Koning, Rob Schuurman, Leonie Ran, Ingrid M. M. Schellens, Ellen Meijer, Henny G. Otten, Suzanne van Dorp, Julia Drylewicz, Esther D. Quakkelaar, Floortje L Pietersma, Jürgen Kuball, Rogier Gaiser, Debbie van Baarle, Nening M. Nanlohy

Publikováno v: Journal of Translational Medicine
Journal of Translational Medicine [E], 14(1). BioMed Central
Drylewicz, J, Schellens, I M M, Gaiser, R, Nanlohy, N M, Quakkelaar, E D, Otten, H, van Dorp, S, Jacobi, R, Ran, L, Spijkers, S, Koning, D, Schuurman, R, Meijer, E, Pietersma, F L, Kuball, J & van Baarle, D 2016, ' Rapid reconstitution of CD4 T cells and NK cells protects against CMV-reactivation after allogeneic stem cell transplantation ', Journal of Translational Medicine, vol. 14, no. 1, pp. 230 . https://doi.org/10.1186/s12967-016-0988-4
Journal of Translational Medicine, 14(1). BioMed Central

Background Epstein-Barr virus and Cytomegalovirus reactivations frequently occur after allogeneic stem cell transplantation (SCT). Methods Here we investigated the role of immune cell reconstitution in the onset and subsequent severity of EBV- and CM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acf5e7c2d440f18ad4b11332273aaf22
https://doi.org/10.1186/s12967-016-0988-4