Výsledky vyhledávání - "Ingrid L. Grupp"

Attenuation of cardiac contractility in Na,K-ATPase α1 isoform-deficient hearts under reduced calcium conditions

Autor: Amy E. Moseley, Ingrid L. Grupp, Jo El J. Schultz, Jerry B. Lingrel, Marc H. Cougnon

Publikováno v: Journal of Molecular and Cellular Cardiology. 37:913-919

We have previously reported that genetic reduction of the Na,K-ATPase alpha1 isoform (alpha1(+/-)) results in a hypocontractile cardiac phenotype. This observation was surprising and unexpected. In order to determine if calcium overload contributes t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fe0eddfbb219aea27beb0a239d155d4
https://doi.org/10.1016/j.yjmcc.2004.06.005

Zobrazit plný text záznamu

Defective intracellular Ca2+ signaling contributes to cardiomyopathy in Type 1 diabetic rats

Autor: W. Jonathan Lederer, Keith W. Dilly, Kin M. Choi, Harvey S. Hahn, Silvia Guatimosim, Mohammed A. Matlib, Brian D. Hoit, Yan Zhong, Ingrid L. Grupp

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 283:H1398-H1408

The goal of the study was to determine whether defects in intracellular Ca2+ signaling contribute to cardiomyopathy in streptozotocin (STZ)-induced diabetic rats. Depression in cardiac systolic and diastolic function was traced from live diabetic rat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::575137899672bd88954fed0d8de1056e
https://doi.org/10.1152/ajpheart.00313.2002

Zobrazit plný text záznamu

The Enhanced Contractility of the Phospholamban-deficient Mouse Heart Persists with Aging

Autor: R. Johnson, Mike Gerst, Evangelia G. Kranias, Peter James, Rajesh Dash, T. Tamura, A.M. Gerdes, Carola Tilgmann, D. Holder, Albrecht Schmidt, Jay Patrick Slack, Ingrid L. Grupp

Publikováno v: Journal of Molecular and Cellular Cardiology. 33:1031-1040

J. P. Slack, I. L. Grupp, R. Dash, D. Holder, A. Schmidt, M. J. Gerst, T. Tamura, C. Tilgmann, P. F. James, R. Johnson, A. M. Gerdes and E. G. Kranias. The Enhanced Contractility of the Phospholamban-deficient Mouse Heart Persists with Aging. Journal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dbf4a582459db694353b4190ff83020
https://doi.org/10.1006/jmcc.2001.1370

Zobrazit plný text záznamu

Overexpression of SERCA2b in the Heart Leads to an Increase in Sarcoplasmic Reticulum Calcium Transport Function and Increased Cardiac Contractility

Autor: Gopal J. Babu, Ingrid L. Grupp, M Sussman, M J Lalli, A L Greene, Muthu Periasamy, Yong Ji

Publikováno v: Journal of Biological Chemistry. 275:24722-24727

The sarcoplasmic reticulum calcium ATPase SERCA2b is an alternate isoform encoded by the SERCA2 gene. SERCA2b is expressed ubiquitously and has a higher Ca(2+) affinity compared with SERCA2a. We made transgenic mice that overexpress the rat SERCA2b c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5697ad276bf48261d76cfe4e46fc6acc
https://doi.org/10.1074/jbc.m001783200

Zobrazit plný text záznamu

Mouse Model of a Familial Hypertrophic Cardiomyopathy Mutation in α-Tropomyosin Manifests Cardiac Dysfunction

Autor: Christian C. Evans, Brian D. Hoit, Greg P. Boivin, R. John Solaro, Beata M. Wolska, David F. Wieczorek, Kathy Pieples, Prabhakar Rethinasamy, Ingrid L. Grupp, Mariappan Muthuchamy

Publikováno v: Circulation Research. 85:47-56

Abstract —To investigate the functional consequences of a tropomyosin (TM) mutation associated with familial hypertrophic cardiomyopathy (FHC), we generated transgenic mice that express mutant α-TM in the adult heart. The missense mutation, which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0da301fe44ed0fc35b34c8ab9419a510
https://doi.org/10.1161/01.res.85.1.47

Zobrazit plný text záznamu

Cardiac-specific Overexpression of the α1 Subunit of the L-type Voltage-dependent Ca2+ Channel in Transgenic Mice

Autor: Ingrid L. Grupp, Heping Cheng, Hiroshi Yamaguchi, William Lewis, Gyula Varadi, Edward G. Lakatta, James N. Muth, Long-Sheng Song, Arnold M. Schwartz, Gabor Mikala

Publikováno v: Journal of Biological Chemistry. 274:21503-21506

The L-type voltage-dependent calcium channel (L-VDCC) regulates calcium influx in cardiac myocytes. Activation of the beta-adrenergic receptor (betaAR) pathway causes phosphorylation of the L-VDCC and that in turn increases Ca(2+) influx. Targeted ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b6e6a71a546377fedbd5975ad0f0ec59
https://doi.org/10.1074/jbc.274.31.21503

Zobrazit plný text záznamu

Identification of a Specific Role for the Na,K-ATPase α2 Isoform as a Regulator of Calcium in the Heart

Autor: G. Roger Askew, Alison L. Woo, Ingrid L. Grupp, Jerry B. Lingrel, Richard A. Walsh, Gunter Grupp, Paul F. James, Michelle L. Croyle

Publikováno v: Molecular Cell. 3:555-563

It is well accepted that inhibition of the Na,K-ATPase in the heart, through effects on the Na/Ca exchanger, raises the intracellular Ca2+ concentration and strengthens cardiac contraction. However, the contribution that individual isoforms make to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407d2f50deb7c5ea7c2c39235fc46c23
https://doi.org/10.1016/s1097-2765(00)80349-4

Zobrazit plný text záznamu

Enhanced Myocardial Contractility and Increased Ca 2+ Transport Function in Transgenic Hearts Expressing the Fast-Twitch Skeletal Muscle Sarcoplasmic Reticulum Ca 2+ -ATPase

Autor: Muthu Periasamy, Ingrid L. Grupp, Evgeny Loukianov, Richard A. Walsh, Gunter Grupp, Jonathan Lytton, Tanya Loukianova, Darryl L. Kirkpatrick, Yong Ji, Debra L. Baker

Publikováno v: Circulation Research. 83:889-897

Abstract —In this study, we investigated whether the fast-twitch skeletal muscle sarco(endo)plasmic reticulum Ca 2+ transport pump (SERCA1a) can functionally substitute the cardiac SERCA2a isoform and how its overexpression affects cardiac contract

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9098c83a1cc5d0a6320a449c234e0a34
https://doi.org/10.1161/01.res.83.9.889

Zobrazit plný text záznamu

β-Tropomyosin Overexpression Induces Severe Cardiac Abnormalities

Autor: Gregory P. Boivin, David F. Wieczorek, Mariappan Muthuchamy, Ingrid L. Grupp

Publikováno v: Journal of Molecular and Cellular Cardiology. 30:1545-1557

Tropomyosin, a coiled-coil dimer, stabilizes actin filaments and is central to the control of calcium-regulated striated muscle contraction. Striated muscle-specific alpha-tropomyosin is the predominant isoform in cardiac muscle, with low levels of b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08823ae22b8e08fa9faa5de5c541ddbf
https://doi.org/10.1006/jmcc.1998.0720

Zobrazit plný text záznamu

Phospholamban ablation enhances relaxation in the murine soleus

Autor: Evangelia G. Kranias, Wusheng Luo, Jay Patrick Slack, Ingrid L. Grupp

Publikováno v: American Journal of Physiology-Cell Physiology. 273:C1-C6

Phospholamban (PLB) is expressed in slow-twitch skeletal, cardiac, and smooth muscles. Several studies have indicated that it is an important regulator of basal contractility and the stimulatory responses to isoproterenol in the mammalian heart. To d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7505728f04ef2be0b98b3429dd10a38
https://doi.org/10.1152/ajpcell.1997.273.1.c1

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání