Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Ingrid J. Poulton"'
Autor:
Dae-Chul Cho, Holly J. Brennan, Rachelle W. Johnson, Ingrid J. Poulton, Jonathan H. Gooi, Brett A. Tonkin, Narelle E. McGregor, Emma C. Walker, David J. Handelsman, T. J. Martin, Natalie A. Sims
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
The strength of long bones is determined by coalescence of trabeculae during corticalization. Here the authors show that this process is regulated by SOCS3 via a mechanism dependent on IL-6 and expression of sex hormones.
Externí odkaz:
https://doaj.org/article/b957b83bc219453cadc23acf2a9623c9
Autor:
Audrey S M Chan, Narelle E McGregor, Ingrid J Poulton, Justin P Hardee, Ellie H‐J Cho, T John Martin, Paul Gregorevic, Natalie A Sims, Gordon S Lynch
Publikováno v:
JBMR Plus, Vol 5, Iss 4, Pp n/a-n/a (2021)
ABSTRACT The development of the musculoskeletal system and its maintenance depends on the reciprocal relationship between muscle and bone. The size of skeletal muscles and the forces generated during muscle contraction are potent sources of mechanica
Externí odkaz:
https://doaj.org/article/6c07d8b5a0524432aa766f8e4b74218b
Autor:
Emma C Walker, Kim Truong, Narelle E McGregor, Ingrid J Poulton, Tsuyoshi Isojima, Jonathan H Gooi, T John Martin, Natalie A Sims
Publikováno v:
eLife, Vol 9 (2020)
Bone strength is determined by its dense cortical shell, generated by unknown mechanisms. Here we use the Dmp1Cre:Socs3f/f mouse, with delayed cortical bone consolidation, to characterise cortical maturation and identify control signals. We show that
Externí odkaz:
https://doaj.org/article/0e2e31dc062d473bb947c073d0b97fe7
Autor:
Natalie K Y Wee, Thaísa F C de Lima, Narelle E McGregor, Emma C Walker, Ingrid J Poulton, Martha Blank, Natalie A Sims
Publikováno v:
Journal of Endocrinology. 255:25-37
Bone strength is partially determined during cortical bone consolidation, a process comprising coalescence of peripheral trabecular bone and its progressive mineralisation. Mice with genetic deletion of suppressor of cytokine signalling 3 (Socs3), an
Autor:
Tsuyoshi Isojima, Emma C Walker, Ingrid J Poulton, Narelle E McGregor, Ian P Wicks, Jonathan H Gooi, T John Martin, Natalie A Sims
Publikováno v:
Journal of Bone and Mineral Research. 37:1876-1890
Bone strength is determined by the structure and composition of its thickened outer shell (cortical bone), yet the mechanisms controlling cortical consolidation are poorly understood. Cortical bone maturation depends on SOCS3-mediated suppression of
Autor:
Martha Blank, Narelle E. McGregor, Lynn Rowley, Louise H. W. Kung, Blessing Crimeen‐Irwin, Ingrid J. Poulton, Emma C. Walker, Jonathan H. Gooi, Shireen R. Lamandé, Natalie A. Sims, John F. Bateman
Publikováno v:
Journal of Cellular and Molecular Medicine. 26:4021-4031
Autor:
Narelle E McGregor, Emma C Walker, Audrey SM Chan, Ingrid J Poulton, Ellie H‐J Cho, Sara H Windahl, Natalie A Sims
Publikováno v:
Journal of Bone and Mineral Research. 37:547-558
Cortical bone develops and changes in response to mechanical load, which is sensed by bone-embedded osteocytes. The bone formation response to load depends on STAT3 intracellular signals, which are upregulated after loading and are subject to negativ
Autor:
Martha Blank, Narelle E McGregor, Lynn Rowley, Louise HW Kung, Blessing Crimeen-Irwin, Ingrid J Poulton, Emma C Walker, Jonathan H Gooi, Shireen R. Lamande, Natalie A Sims, John F. Bateman
The inherited brittle bone disease osteogenesis imperfecta (OI) is commonly caused by COL1A1 and COL1A2 mutations that disrupt the collagen I triple helix. This causes intracellular endoplasmic reticulum (ER) retention of the misfolded collagen and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05120277a840eb60897de5d4822b7599
https://doi.org/10.1101/2022.02.23.481692
https://doi.org/10.1101/2022.02.23.481692
Autor:
null Narelle E McGregor, null Emma C Walker, null Audrey S M Chan, null Ingrid J Poulton, null Ellie H‐J Cho, null Sara H Windahl, null Natalie A Sims
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc4369eb972aa8aa112a30b601234846
https://doi.org/10.1002/jbmr.4484/v2/response1
https://doi.org/10.1002/jbmr.4484/v2/response1
Autor:
Christopher S. Kovacs, Patricia W. M. Ho, Jonathan H. Gooi, Niloufar Ansari, Tsuyoshi Isojima, Blessing Crimeen-Irwin, Evdokia Dimitriadis, Narelle E. McGregor, Natalie A. Sims, T. John Martin, Ingrid J Poulton, Mark R. Forwood
Publikováno v:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral ResearchREFERENCES. 36(10)
Parathyroid hormone-related protein (PTHrP, gene name Pthlh) is a pleiotropic regulator of tissue homeostasis. In bone, Dmp1Cre-targeted PTHrP deletion in osteocytes causes osteopenia and impaired cortical strength. We report here that this outcome d