Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Ingrid H. Sarelius"'
Autor:
Luca Goitre, Peter V. DiStefano, Andrea Moglia, Nicholas Nobiletti, Eva Baldini, Lorenza Trabalzini, Julie Keubel, Eliana Trapani, Vladimir V. Shuvaev, Vladimir R. Muzykantov, Ingrid H. Sarelius, Saverio Francesco Retta, Angela J. Glading
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract The intracellular scaffold KRIT1/CCM1 is an established regulator of vascular barrier function. Loss of KRIT1 leads to decreased microvessel barrier function and to the development of the vascular disorder Cerebral Cavernous Malformation (CC
Externí odkaz:
https://doaj.org/article/6fc3adc7ae70457492848b492ff196e1
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128378 (2015)
P-selectin and P-selectin glycoprotein ligand-1 (PSGL-1) play important roles in mediating the inflammatory cascade. Selectin kinetics, together with neutrophil hydrodynamics, regulate the fundamental adhesion cascade of cell tethering and rolling on
Externí odkaz:
https://doaj.org/article/1ef33e20e27a4f958e47033f893a29a8
Autor:
Ingrid H. Sarelius, Coral L. Murrant
Publikováno v:
The Journal of Physiology. 593:4699-4711
The focus of this review is on local mechanisms modifying arteriolar resistance to match blood flow to metabolism. In skeletal muscle many local mediators are known, including K(+) , nitric oxide (NO), purines and prostaglandins. Each accounts for ab
Publikováno v:
Journal of Biological Chemistry. 289:33054-33065
Disruption of endothelial cell-cell contact is a key event in many cardiovascular diseases and a characteristic of pathologically activated vascular endothelium. The CCM (cerebral cavernous malformation) family of proteins (KRIT1 (Krev-interaction tr
Autor:
Lisa Ronacher, Julia M. Keubel, Angela Glading, Ravi S. Misra, Frances E. Lund, Irina Lerman, Ingrid H. Sarelius, Maripat Corr
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 32:2702-2710
Objective— The regulation of vascular permeability, leukocyte trafficking, and the integrity of endothelial cell–cell contacts are closely linked by a complex mechanism of interregulation. Here, we investigate the role of Krev interaction–trapp
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 311(4)
Endothelial cells (EC) respond to mechanical forces such as shear stress in a variety of ways, one of which is cytoskeletal realignment in the direction of flow. Our earlier studies implicated the extracellular matrix protein fibronectin in mechanose
Publikováno v:
The Journal of Immunology. 185:7057-7066
To exit blood vessels, lumenally adhered monocytes and neutrophils crawl towards specific locations that support transmigration. Using intravital confocal microscopy of anesthetized mouse cremaster muscle we separately examined the intralumenal crawl
Autor:
Ingrid H. Sarelius, Ronen Sumagin
Publikováno v:
The Journal of Immunology. 184:5242-5252
Leukocyte transmigration occurs at specific locations (portals) on the endothelium, but the nature of these portals is not clear. Using intravital confocal microscopy of anesthetized mouse cremaster muscle in combination with immunofluorescence label
Autor:
Ulrich Pohl, Ingrid H. Sarelius
Publikováno v:
Acta Physiologica. 199:349-365
Understanding the control mechanisms of blood flow within the vasculature of skeletal muscle is clearly fascinating from a theoretical point of view due to the extremely tight coupling of tissue oxygen demands and blood flow. It also has practical im
Publikováno v:
Annals of Biomedical Engineering
A recent analytical solution of the three-dimensional Stokes flow through a bumpy tube predicts that for a given bump area, there exists an optimal circumferential wavenumber which minimizes flow resistance. This study uses measurements of microvesse